DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and Apl

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_730182.1	Gene:	Apl / 59216	FlyBaseID:	FBgn0042178	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	1123	Identity:	195/1123 - (17%)
Similarity:	349/1123 - (31%)	Gaps:	460/1123 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPT--RSLSGLILKNNIR--M 76
            :||..::||:                       :.|||::...|.|.  |.::.::||..::  .
  Fly    27 MLKAYENPDS-----------------------LLVLTQIVMSDRPVQERQVAAVLLKRRVKKLR 68

  Fly    77 HGTTLQPEIVEYIKHECLQA-VGDASPLIRATVGILITTIA--SNGGLHNW-PQLLPSLCEMLDN 137
            |...:..|....||...||. :......::.||..:|.::.  ..|..::| .::|..:.|...:
  Fly    69 HWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEGEQNSWREEILKFIYERCSS 133

  Fly   138 QDYNVCE---GAFSALQKICEDS------------AEILDSAALNRPLNIMIPKFLEYFKHSS-- 185
            .|....|   ..||:|.....|.            |.||.:|..|.  |:..|........|.
  Fly   134 PDPIESERGSSIFSSLMDAAPDQFSDHTDTMFPLLAGILVTAEANG--NMATPTVHNMLTGSCFL 196

  Fly   186 -PKIRSHAIACINQFIINRSQALMLNIDSFIENLFHL----SSDEDHEVRKNVCH---GLVMLLE 242
             |.:..|:.|  .|.::.....::..:.:|:|..:.:    :.|....:.::|.|   |.|.||
  Fly   197 LPFVSGHSNA--EQIVVKAVPLILKALAAFVEKGYSIEFMGAFDIIDSMAEHVPHLLTGNVKLL- 258

  Fly   243 VRMDRLMPHMSQIIEY--MLLRTQDTDEGVALEASEF---WLSLAEQSICKD-VLAPYLAQLAPV 301
                         :|:  |:.|.:..|..:.::...|   .:.|.::.|.|. :|.|.|:.|..|
  Fly   259 -------------LEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEV 310

  Fly   302 LVRGMRYSEVDIILLKGNVEEDDMVPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFED 366
            :.                  :||:                       :||        |||.|
  Fly   311 IC------------------QDDL-----------------------EEG--------DDDYF-- 324

  Fly   367 GMDDDSSLSEWNLRKCSAAALDVLA-NVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAE 430
                 ||.|..:....:|..||::| ::..:..:|.:|.:|:..|...|.|::.|..:.:|.|||
  Fly   325 -----SSESLSSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVIAE 384

  Fly   431 GCMQGMIQHLPELIPYLISC-LSDKKALVRSITCWTLSRYANWV--------------------- 473
            ||.:.:.:...|::..:|.. :.|....||:...:.|.:::.::
  Fly   385 GCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYLNQ 449

  Fly   474 ------VNQPH------------------DQYLKPLMEELLKRIL-----DSNKRVQEAACSAFA 509
                  |.:|.                  |:.:.|.:..|:.|:.     .::.:::|.|.||.|
  Fly   450 LVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMREMALSAIA 514

  Fly   510 TLEEEACTELVPYLEYILKTLVFAFSK------YQHK-----------------NLLILYD---- 547
            .:...|...|:||...|:..|.....|      |..:                 |::.|.|
  Fly   515 AVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADDTMN 579

  Fly   548 -----------------AVGTLADSVGHHLNK------PQYIDILMPPLIDKWNLL--------- 580
                             ::..|..|:...:|:      |::||.:|..:|...:::
  Fly   580 FCLMMLEDGPDDPEYRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVIFSEDMVPNVSDNADD 644

  Fly   581 ------------------KDDDKDLFPL-----------LECLSSIATALQSGFLPYCDPVYRRC 616
                              .:||:|.:|:           :..|...||...:.|.||....:...
  Fly   645 DLALVDAPDIEIDLEHTDDEDDQDAYPVENDYIVEKEEAILSLKEFATHTGAAFAPYLQSAFENV 709

  Fly   617 ISLIEQTINQEMLCKQNQTYDHPDKERMIVALDLLSGL---------AEGLDRHIETLVAN-SNI 671
            ..:|                |||..:..:..:|.:...         |.||.|..|..:.. ::|
  Fly   710 YKMI----------------DHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHI 758

  Fly   672 M--------------------------------HLLYQCMQDV---------------------- 682
            |                                .|::.|::|:
  Fly   759 MRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGCIRDIFTNKMACQFNEESGGGDDECSE 823

  Fly   683 --------------------------------------------------LPEVRQSSFALLGDL 697
                                                              |||.|...:..|.|.
  Fly   824 ESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALADC 888

  Fly   698 TKA---CFPHVHPFMADFFPILGQNLNPDFIS--------VCNNATWAIGEICMKLGEETKQYIR 751
            .||   |       .|.:|    ..|.|.||:        ...|:.:|:|||.....|::.:...
  Fly   889 CKALKGC-------CATYF----DALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYP 942

  Fly   752 LVLSDLFIIINRPNTPKTLLENTAITIGR----------LGYVCPVEVAPYLPEFVRQWCTSLRH 806
            .:|..|...|.|.:.| ..::|....:.|          ||.|.||            |   |.|
  Fly   943 TILQALSEAIVRESVP-AAMDNICGAVARLIVTNPDSVPLGQVLPV------------W---LNH 991

  Fly   807 IR------DNDEKDSAFR 818
            :.      :||....|||
  Fly   992 LPLKDDTVENDVIQKAFR 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	14/71 (20%)
		ARM	127..234	CDD:237987	23/128 (18%)
		HEAT repeat	127..155	CDD:293787	7/30 (23%)
		HEAT repeat	172..202	CDD:293787	6/32 (19%)
		HEAT repeat	213..239	CDD:293787	6/32 (19%)
		HEAT repeat	252..281	CDD:293787	5/33 (15%)
		HEAT_2	399..507	CDD:290374	27/158 (17%)
		HEAT repeat	402..430	CDD:293787	8/27 (30%)
		HEAT_EZ	415..469	CDD:290247	14/54 (26%)
		HEAT repeat	442..472	CDD:293787	6/30 (20%)
		HEAT repeat	481..510	CDD:293787	7/33 (21%)
		HEAT repeat	670..702	CDD:293787	13/138 (9%)
		HEAT repeat	711..737	CDD:293787	7/33 (21%)
Apl	NP_730182.1	IBN_N	29..90	CDD:197981	17/83 (20%)
		HEAT repeat	356..384	CDD:293787	8/27 (30%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	2/34 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438718
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940