DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and Arts

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001261957.1	Gene:	Arts / 59215	FlyBaseID:	FBgn0042177	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	832	Identity:	157/832 - (18%)
Similarity:	313/832 - (37%)	Gaps:	225/832 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPT--RSLSGLILKNNIR--M 76
            :||..::||:                       :.|||::...|.|.  |.::.::||..::  .
  Fly    27 MLKAYENPDS-----------------------LLVLTQIVMSDRPVQERQVAAVLLKRRVKKLR 68

  Fly    77 HGTTLQPEIVEYIKHECLQA-VGDASPLIRATVGILITTIA--SNGGLHNW-PQLLPSLCEMLDN 137
            |...:..|....||...||. :......::.||..:|.::.  .....::| .::|..:.|...:
  Fly    69 HWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYERCSS 133

  Fly   138 QDYNVCE---GAFSALQKICEDS------------AEILDSAALNRPLNIMIPKFLEYFKHSS-- 185
            .|....|   ..||:|.....|.            |.||.:|..|.  |:..|..     |:.
  Fly   134 PDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANG--NMATPTV-----HNMLA 191

  Fly   186 ------PKIRSHAIACINQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVR 244
                  |.|..|:.|  .|.::.....::..:.:|.|           :...|...|...::: .
  Fly   192 GTCVLLPFISGHSDA--EQIMVKAVPLILKALAAFAE-----------KGNSNEFMGAFDIID-S 242

  Fly   245 MDRLMPHM-----SQIIEY--MLLRTQDTDEGVALEASEF---WLSLAEQSICKD-VLAPYLAQL 298
            |...:||:     ..::|:  |:.|.:..|..:.::...|   .:.|.::.|.|. :|.|.|:.|
  Fly   243 MAEYVPHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVL 307

  Fly   299 APVLVRGMRYSEVDIILLKGNVEEDDMVPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDE 363
            ..|:.                  :||:                       :||        |||.
  Fly   308 FEVIC------------------QDDL-----------------------KEG--------DDDY 323

  Fly   364 FEDGMDDDSSLSEWNLRKCSAAALDVLA-NVFREDCLPVVLPILKETLFHQEWVIKESGVLALGA 427
            |       ||.|..:....:|..||::| ::..:..:|.:|.:|:..|...|.|::.|..:.:|.
  Fly   324 F-------SSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGV 381

  Fly   428 IAEGCMQGMIQHLPELIPYLISC-LSDKKALVRSITCWTLSRYANWVVNQPH------------D 479
            |||||.:.:.:...|::..:|.. :.|....||:...:.|.:::.::  ||.            .
  Fly   382 IAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFL--QPTICKFAPQILPVLF 444

  Fly   480 QYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLEYILKTLVFAFSKYQHKNLL- 543
            .||..|:.||  ::.:.:.:..:....|..|..|....::||||..::..| |...:.|:.|.:
  Fly   445 DYLNQLVLEL--KVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRL-FGVMEPQNSNQMR 506

  Fly   544 -ILYDAVGTLADSVGHHLNK--PQYIDILMPPLIDKWNLLKDDDKDLF----PLLECLSSIATAL 601
             :...|:..::.:...:|..  |:.:.:|...|:      ||..|:::    ..::.|:::...|
  Fly   507 EMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLV------KDCPKEMYSQRIQAIDTLAALCREL 565

  Fly   602 -QSGFLPYCDPVYRRCISLIEQTINQEMLCKQNQTYDHPDKERMIVALDLLSGLA---------- 655
             :...:|..|.....|:.::|            ...|.|:..|.|  .:|:|.|:
  Fly   566 GKDNIIPLADETMNFCLMMLE------------DGPDDPEFRRSI--YNLMSSLSSVVNESMASV 616

  Fly   656 --EGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMA------DF 712
              :.:||.:|:::::           :|::|.|..::   ..||.....|.:...:.      |.
  Fly   617 FPKFIDRIMESVISS-----------EDMVPNVSDNA---EDDLALVDAPDIEIDLEHTDDEDDQ 667

  Fly   713 FPILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRP 764
            ...||:|   |:|.....|..::.|.....|.....|::....:::.:|:.|
  Fly   668 DAYLGEN---DYIVEKEEAILSLKEFATHTGAAFAPYLQSAFENVYKMIDHP 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	14/71 (20%)
		ARM	127..234	CDD:237987	24/129 (19%)
		HEAT repeat	127..155	CDD:293787	7/30 (23%)
		HEAT repeat	172..202	CDD:293787	7/37 (19%)
		HEAT repeat	213..239	CDD:293787	4/25 (16%)
		HEAT repeat	252..281	CDD:293787	5/38 (13%)
		HEAT_2	399..507	CDD:290374	26/120 (22%)
		HEAT repeat	402..430	CDD:293787	8/27 (30%)
		HEAT_EZ	415..469	CDD:290247	14/54 (26%)
		HEAT repeat	442..472	CDD:293787	6/30 (20%)
		HEAT repeat	481..510	CDD:293787	6/28 (21%)
		HEAT repeat	670..702	CDD:293787	5/31 (16%)
		HEAT repeat	711..737	CDD:293787	7/25 (28%)
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/83 (20%)
		HEAT repeat	356..384	CDD:293787	8/27 (30%)
		HEAT repeat	397..427	CDD:293787	5/29 (17%)
		HEAT repeat	438..473	CDD:293787	6/36 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940