DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and tnpo1

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_021327307.1	Gene:	tnpo1 / 562607	ZFINID:	ZDB-GENE-080819-1	Length:	891	Species:	Danio rerio

Alignment Length:	893	Identity:	666/893 - (74%)
Similarity:	766/893 - (85%)	Gaps:	8/893 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSLSG 67
            |:|..:|||||:.:|||||||||:||.:||.|||:.|:|||||||||:|||||||||||||||||
Zfish     5 WKPDEQGLQQILQLLKESQSPDTSTQRSVQQKLEQLNQYPDFNNYLIFVLTKLKTEDEPTRSLSG 69

  Fly    68 LILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPSLC 132
            ||||||::.|.......:.::||:||||::||:|||||||||||||||||.|.|.|||:|||.||
Zfish    70 LILKNNVKAHYQNFPNGVSDFIKNECLQSIGDSSPLIRATVGILITTIASKGELQNWPELLPKLC 134

  Fly   133 EMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIACIN 197
            .:||::|||.|||||.|||||||||||||||..|.||||:||||||::|||||||||||||||:|
Zfish   135 LLLDSEDYNTCEGAFGALQKICEDSAEILDSDMLERPLNVMIPKFLQFFKHSSPKIRSHAIACVN 199

  Fly   198 QFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYMLLR 262
            ||||:|:|||||:||.||||||.|:.||:.|||||||..||||||||:|||:|||..||||||.|
Zfish   200 QFIISRTQALMLHIDPFIENLFALAGDEEPEVRKNVCRALVMLLEVRLDRLLPHMHNIIEYMLQR 264

  Fly   263 TQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDMVP 327
            |||.||.|||||.||||:||||.:||:||..:|.:|.||||.||:|||:|||||||:||||:.:|
Zfish   265 TQDQDENVALEACEFWLTLAEQPVCKEVLCGHLPKLTPVLVNGMKYSEIDIILLKGDVEEDEAIP 329

  Fly   328 DREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVLAN 392
            |.|:|||||||:||  |:....|||.....||||   ||.:|||.::|:||||||||||||||||
Zfish   330 DNEQDIRPRFHRSR--TVAQQHEGGDSIEEDDDD---EDDLDDDETISDWNLRKCSAAALDVLAN 389

  Fly   393 VFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKAL 457
            |||:|.|..:||:|||.|||.||:|||||:|.|||||||||||||.:||||||:|:.||||||||
Zfish   390 VFRDDLLLHILPLLKELLFHPEWLIKESGILVLGAIAEGCMQGMIPYLPELIPHLVLCLSDKKAL 454

  Fly   458 VRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 522
            |||||||||||||:|||:||.|.||||||.|||||||||||||||||||||||||||||||||||
Zfish   455 VRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 519

  Fly   523 LEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDKDL 587
            |.|||.||||||||||||||||||||:||||||||||||||:||.:||||||.|||.|||:||||
Zfish   520 LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNQLKDEDKDL 584

  Fly   588 FPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCKQNQT--YDHPDKERMIVALDL 650
            |||||||||:||||||||||||:|||:||::|:::|:.|.:| .|||.  |:.|||:.|||||||
Zfish   585 FPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAVL-HQNQPEYYEAPDKDFMIVALDL 648

  Fly   651 LSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFPI 715
            ||||||||..:||.|||.|||:.|:||||||.:|||||||||||||||||.|.||.|.:|:|.||
Zfish   649 LSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKASFQHVKPCIANFMPI 713

  Fly   716 LGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIGR 780
            ||.||||:.||||||||||||||.:::|.|.:.|:.|||..|..|||||||||||||||||||||
Zfish   714 LGTNLNPELISVCNNATWAIGEISIQMGSEMQPYVPLVLQQLVEIINRPNTPKTLLENTAITIGR 778

  Fly   781 LGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASW 845
            ||||||.||||.|.:|:|.||||||:||||:||||||||:|.||||||.|||.||||||||:|||
Zfish   779 LGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMITVNPGGVVQDFIFFCDAVASW 843

  Fly   846 VNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            :||.:||.:|..|||||||.|||:||||||.:||||.|.|||...|.:
Zfish   844 MNPKDDLREMFYKILHGFKNQVGDENWRRFSDQFPPPLKERLAAFYGV 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	44/66 (67%)
		ARM	127..234	CDD:237987	83/106 (78%)
		HEAT repeat	127..155	CDD:293787	20/27 (74%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	17/25 (68%)
		HEAT repeat	252..281	CDD:293787	22/28 (79%)
		HEAT_2	399..507	CDD:290374	88/107 (82%)
		HEAT repeat	402..430	CDD:293787	20/27 (74%)
		HEAT_EZ	415..469	CDD:290247	45/53 (85%)
		HEAT repeat	442..472	CDD:293787	26/29 (90%)
		HEAT repeat	481..510	CDD:293787	27/28 (96%)
		HEAT repeat	670..702	CDD:293787	26/31 (84%)
		HEAT repeat	711..737	CDD:293787	20/25 (80%)
tnpo1	XP_021327307.1	KAP95	24..760	CDD:227540	552/741 (74%)
		HEAT repeat	129..157	CDD:293787	20/27 (74%)
		HEAT repeat	174..204	CDD:293787	25/29 (86%)
		HEAT repeat	215..241	CDD:293787	17/25 (68%)
		HEAT repeat	254..283	CDD:293787	22/28 (79%)
		HEAT repeat	404..424	CDD:293787	14/19 (74%)
		HEAT repeat	440..468	CDD:293787	24/27 (89%)
		HEAT repeat	481..511	CDD:293787	28/29 (97%)
		HEAT repeat	522..548	CDD:293787	23/25 (92%)
		HEAT repeat	563..594	CDD:293787	25/30 (83%)
		HEAT repeat	663..699	CDD:293787	29/35 (83%)
		HEAT repeat	709..739	CDD:293787	23/29 (79%)
		HEAT repeat	750..778	CDD:293787	23/27 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	673	1.000	Domainoid score	I139
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5358
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I129
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm25585
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R601
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870