DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and tnpo2

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001004003.1	Gene:	tnpo2 / 445499	ZFINID:	ZDB-GENE-040822-16	Length:	889	Species:	Danio rerio

Alignment Length:	894	Identity:	654/894 - (73%)
Similarity:	765/894 - (85%)	Gaps:	6/894 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSL 65
            |.|:|..:||||::.:|::||||:||||.|||.|||:.|::||||||||:|||:|||||||||||
Zfish     1 MEWQPDEQGLQQVLQLLRDSQSPNTATQRAVQQKLEQLNQFPDFNNYLIFVLTRLKTEDEPTRSL 65

  Fly    66 SGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPS 130
            ||||||||:::|.....|.:..:||.|||..:||.|||||||:|||||||::.|.|..||:|||.
Zfish    66 SGLILKNNVKVHYQNFPPAVAHFIKQECLNNIGDPSPLIRATIGILITTISTKGELQTWPELLPQ 130

  Fly   131 LCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIAC 195
            ||.|||::|||:|||:|.|||||||||:|:|||.||||||||||||||::|||.||||||||:||
Zfish   131 LCNMLDSEDYNICEGSFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAVAC 195

  Fly   196 INQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYML 260
            :|||||:|:||||.|||:|||:||.||||||.|||||||..||||||||:|||:|||..|:||||
Zfish   196 VNQFIISRAQALMDNIDTFIESLFALSSDEDSEVRKNVCRALVMLLEVRVDRLLPHMRSIVEYML 260

  Fly   261 LRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDM 325
            .||||.||.|:|||.||||:||||.||||||:.:||||.||||.||:|||:|||||||:||||:.
Zfish   261 QRTQDPDENVSLEACEFWLTLAEQPICKDVLSGHLAQLVPVLVNGMKYSEIDIILLKGDVEEDEA 325

  Fly   326 VPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVL 390
            |||.|:||:|||||||..|:|  .||..|..|:|.:|   |..|||.|||:||||||||||||||
Zfish   326 VPDNEQDIKPRFHKSRTVTLR--HEGDEGEEGEDSED---DDDDDDDSLSDWNLRKCSAAALDVL 385

  Fly   391 ANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKK 455
            |||||::.||.:||:|||.|||.:||:||||:|.||||||||||.|:.:||||||:|:.||.|||
Zfish   386 ANVFRDELLPHLLPVLKELLFHPDWVVKESGILVLGAIAEGCMQDMVLYLPELIPHLVQCLCDKK 450

  Fly   456 ALVRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELV 520
            ||||||.||||||||:|||:||.|.||||||.|||||||||||:|||||||||||||||||||||
Zfish   451 ALVRSIACWTLSRYAHWVVSQPADSYLKPLMTELLKRILDSNKKVQEAACSAFATLEEEACTELV 515

  Fly   521 PYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDK 585
            |||.|||.||||||||||||||||||||:||||||||||||:|:||..||||||.|||.|||:||
Zfish   516 PYLSYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDK 580

  Fly   586 DLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCKQN-QTYDHPDKERMIVALD 649
            |||||||||||:||||||||||||:|||:||::|:::.:.|.|:..|. :.|:.|||:.||||||
Zfish   581 DLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKNLAQAMMYNQQPEQYEAPDKDFMIVALD 645

  Fly   650 LLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFP 714
            |||||||||..::|.||..||||.||:|||||.:|||||||||||||||||||.||.|.:|:|.|
Zfish   646 LLSGLAEGLGANVEQLVTRSNIMTLLFQCMQDTMPEVRQSSFALLGDLTKACFLHVKPCVAEFMP 710

  Fly   715 ILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIG 779
            :||.||||:|||||||||||||||.|::|.|.:.::.|||::|..||||||||||||||||||||
Zfish   711 VLGLNLNPEFISVCNNATWAIGEITMQMGTEMQPFVALVLNNLVEIINRPNTPKTLLENTAITIG 775

  Fly   780 RLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIAS 844
            |||||||.||||.||:|:|.||||||:||||:||||||||:|.||.|||.|||.||||||||:||
Zfish   776 RLGYVCPQEVAPMLPQFIRPWCTSLRNIRDNEEKDSAFRGICVMIGVNPGGVVQDFIFFCDAVAS 840

  Fly   845 WVNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||.|.:||..|..|||||||.|||||||::|.|||||.|.|||:..|.:
Zfish   841 WVTPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPQLKERLSACYGV 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	42/66 (64%)
		ARM	127..234	CDD:237987	84/106 (79%)
		HEAT repeat	127..155	CDD:293787	20/27 (74%)
		HEAT repeat	172..202	CDD:293787	24/29 (83%)
		HEAT repeat	213..239	CDD:293787	19/25 (76%)
		HEAT repeat	252..281	CDD:293787	20/28 (71%)
		HEAT_2	399..507	CDD:290374	83/107 (78%)
		HEAT repeat	402..430	CDD:293787	19/27 (70%)
		HEAT_EZ	415..469	CDD:290247	41/53 (77%)
		HEAT repeat	442..472	CDD:293787	24/29 (83%)
		HEAT repeat	481..510	CDD:293787	26/28 (93%)
		HEAT repeat	670..702	CDD:293787	27/31 (87%)
		HEAT repeat	711..737	CDD:293787	20/25 (80%)
tnpo2	NP_001004003.1	IBN_N	32..99	CDD:281761	42/66 (64%)
		HEAT repeat	93..114	CDD:293787	15/20 (75%)
		ARM	125..240	CDD:237987	89/114 (78%)
		HEAT repeat	127..155	CDD:293787	20/27 (74%)
		HEAT repeat	165..202	CDD:293787	31/36 (86%)
		HEAT repeat	213..239	CDD:293787	19/25 (76%)
		HEAT_EZ	228..275	CDD:290247	35/46 (76%)
		HEAT repeat	252..281	CDD:293787	20/28 (71%)
		HEAT repeat	397..425	CDD:293787	19/27 (70%)
		HEAT_2	398..502	CDD:290374	81/103 (79%)
		HEAT_EZ	410..464	CDD:290247	41/53 (77%)
		HEAT repeat	437..467	CDD:293787	24/29 (83%)
		HEAT repeat	476..505	CDD:293787	26/28 (93%)
		HEAT repeat	667..695	CDD:293787	23/27 (85%)
		HEAT repeat	707..737	CDD:293787	23/29 (79%)
		HEAT repeat	748..776	CDD:293787	23/27 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596452
Domainoid	1	1.000	673	1.000	Domainoid score	I139
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1364	1.000	Inparanoid score	I129
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm25585
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	O	PTHR10527
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770