DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and TNPO1

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_002261.3	Gene:	TNPO1 / 3842	HGNCID:	6401	Length:	898	Species:	Homo sapiens

Alignment Length:	892	Identity:	661/892 - (74%)
Similarity:	760/892 - (85%)	Gaps:	7/892 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSLSG 67
            |:|..:|||||:.:|||||||||..|..||.|||:.|:|||||||||:||||||:||||||||||
Human    13 WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSG 77

  Fly    68 LILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPSLC 132
            ||||||::.|.......:.::||.|||..:||:|||||||||||||||||.|.|.|||.|||.||
Human    78 LILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLC 142

  Fly   133 EMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIACIN 197
            .:||::|||.|||||.|||||||||||||||..|:|||||||||||::||||||||||||:||:|
Human   143 SLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVN 207

  Fly   198 QFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYMLLR 262
            ||||:|:|||||:|||||||||.|:.||:.|||||||..||||||||||||:|||..|:||||.|
Human   208 QFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR 272

  Fly   263 TQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDMVP 327
            |||.||.|||||.||||:||||.||||||..:|.:|.||||.||:||::|||||||:||||:.:|
Human   273 TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIP 337

  Fly   328 DREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVLAN 392
            |.|:|||||||:||  |:....:.......||||||    :|||.::|:||||||||||||||||
Human   338 DSEQDIRPRFHRSR--TVAQQHDEDGIEEEDDDDDE----IDDDDTISDWNLRKCSAAALDVLAN 396

  Fly   393 VFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKAL 457
            |:|::.||.:||:|||.|||.|||:||||:|.|||||||||||||.:||||||:||.||||||||
Human   397 VYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKAL 461

  Fly   458 VRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 522
            |||||||||||||:|||:||.|.||||||.|||||||||||||||||||||||||||||||||||
Human   462 VRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 526

  Fly   523 LEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDKDL 587
            |.|||.||||||||||||||||||||:||||||||||||||:||.:||||||.|||:|||:||||
Human   527 LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDL 591

  Fly   588 FPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCK-QNQTYDHPDKERMIVALDLL 651
            |||||||||:||||||||||||:|||:||::|:::|:.|.||.. |...|:.|||:.||||||||
Human   592 FPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLL 656

  Fly   652 SGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFPIL 716
            |||||||..:||.|||.|||:.|:||||||.:|||||||||||||||||||.||.|.:|||.|||
Human   657 SGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPIL 721

  Fly   717 GQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIGRL 781
            |.||||:|||||||||||||||.:::|.|.:.||.:||..|..||||||||||||||||||||||
Human   722 GTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRL 786

  Fly   782 GYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASWV 846
            |||||.||||.|.:|:|.||||||:||||:||||||||:|.||:|||:||:.||||||||:|||:
Human   787 GYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851

  Fly   847 NPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||.:||..|..|||||||.|||:||||||.:|||..|.|||...|.:
Human   852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	42/66 (64%)
		ARM	127..234	CDD:237987	84/106 (79%)
		HEAT repeat	127..155	CDD:293787	20/27 (74%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	18/25 (72%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT_2	399..507	CDD:290374	90/107 (84%)
		HEAT repeat	402..430	CDD:293787	20/27 (74%)
		HEAT_EZ	415..469	CDD:290247	46/53 (87%)
		HEAT repeat	442..472	CDD:293787	27/29 (93%)
		HEAT repeat	481..510	CDD:293787	27/28 (96%)
		HEAT repeat	670..702	CDD:293787	26/31 (84%)
		HEAT repeat	711..737	CDD:293787	22/25 (88%)
TNPO1	NP_002261.3	HEAT 1. /evidence=ECO:0000269\|PubMed:10353245	19..46		18/26 (69%)
		KAP95	32..767	CDD:227540	550/740 (74%)
		HEAT 2. /evidence=ECO:0000269\|PubMed:10353245	51..89		32/37 (86%)
		HEAT 3. /evidence=ECO:0000269\|PubMed:10353245	98..131		25/32 (78%)
		HEAT repeat	103..124	CDD:293787	16/20 (80%)
		HEAT 4. /evidence=ECO:0000269\|PubMed:10353245	137..174		29/36 (81%)
		HEAT repeat	137..165	CDD:293787	20/27 (74%)
		HEAT 5. /evidence=ECO:0000269\|PubMed:10353245	181..211		25/29 (86%)
		HEAT repeat	182..212	CDD:293787	25/29 (86%)
		HEAT repeat	223..249	CDD:293787	18/25 (72%)
		HEAT 6. /evidence=ECO:0000269\|PubMed:10353245	224..251		19/26 (73%)
		HEAT repeat	262..291	CDD:293787	21/28 (75%)
		HEAT 7. /evidence=ECO:0000269\|PubMed:10353245	263..290		19/26 (73%)
		HEAT 8. /evidence=ECO:0000269\|PubMed:10353245	306..397		58/96 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..374		11/32 (34%)
		HEAT 9. /evidence=ECO:0000269\|PubMed:10353245	405..433		19/27 (70%)
		HEAT repeat	407..431	CDD:293787	17/23 (74%)
		HEAT 10. /evidence=ECO:0000269\|PubMed:10353245	445..472		24/26 (92%)
		HEAT repeat	447..475	CDD:293787	25/27 (93%)
		HEAT 11. /evidence=ECO:0000269\|PubMed:10353245	486..519		31/32 (97%)
		HEAT repeat	488..518	CDD:293787	28/29 (97%)
		HEAT 12. /evidence=ECO:0000269\|PubMed:10353245	527..560		29/32 (91%)
		HEAT repeat	529..555	CDD:293787	23/25 (92%)
		HEAT 13. /evidence=ECO:0000269\|PubMed:10353245	568..606		30/37 (81%)
		HEAT repeat	570..601	CDD:293787	25/30 (83%)
		HEAT 14. /evidence=ECO:0000269\|PubMed:10353245	614..665		30/50 (60%)
		HEAT 15. /evidence=ECO:0000269\|PubMed:10353245	676..707		25/30 (83%)
		HEAT 16. /evidence=ECO:0000269\|PubMed:10353245	715..748		26/32 (81%)
		HEAT 17. /evidence=ECO:0000269\|PubMed:10353245	756..791		28/34 (82%)
		HEAT 18. /evidence=ECO:0000269\|PubMed:10353245	799..832		23/32 (72%)
		HEAT 19. /evidence=ECO:0000269\|PubMed:10353245	841..872		21/30 (70%)
		HEAT 20. /evidence=ECO:0000269\|PubMed:10353245	875..895		13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	673	1.000	Domainoid score	I142
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5358
Inparanoid	1	1.050	1356	1.000	Inparanoid score	I136
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm42114
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R601
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870