Protein Alignment Tnpo and Fs(2)Ket

DIOPT Version :10

• Sequence 1: NP_477368.1
• Gene: Tnpo / 38721
• FlyBaseID: FBgn0024921
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_477496.1
• Gene: Fs(2)Ket / 35336
• FlyBaseID: FBgn0262743
• Length: 884
• Species: Drosophila melanogaster
• Alignment Length: 968
• Identity: 192/968 - (19%)
• Similarity: 346/968 - (35%)
• Gaps: 229/968 - (23%)

  Fly    12 QIIAILKESQSPDTATQMAVQMKLEE--FNRYPDFNNYLIYVLTKLKTEDEPTRSLSGLILKNNI 74
            |:||||:::.|||....::.:..||:  .:..|:|...|..:|.. .......|..:||.|||::
  Fly     8 QLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVN-TANSAVARMAAGLQLKNHL 71

  Fly    75 -------------RMHGTTLQPEIVEYIKHECLQAVG--DASPLIRATVGILITTIASNGGLHNW 124
                         |.|  ....||.|.||:..|.|:|  :..|...|.....:..|..  .::.|
  Fly    72 TSKDEKVSQQYQDRWH--QFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIEL--PINRW 132

  Fly   125 PQLLPSLCEMLDNQDYNVC--EGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPK 187
            |.|:.:|...:.::..:..  |.|..|:..||:|    :....:....|.::...:...:...|.
  Fly   133 PMLIQTLVNKVVSEGSSEMHRESALEAIGYICQD----IRFGVMENQSNDVLTAIIHGMRKVEPS 193

  Fly   188 IRSHAIACINQFIINRSQALMLNIDSFIENLF------HLSSDEDHEVRKNVCHGLVMLLEVRMD 246
              :|........:.|..:....|.:..:|..|      ..:..:|.::.......||.::.:...
  Fly   194 --NHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQ 256

  Fly   247 RLMPHMSQIIEYMLLRTQDTD-EGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSE 310
            .:.|:|:|.:..:.|....:| :.|||:..|||     .::|.:                    |
  Fly   257 YMEPYMAQALFPITLAAMKSDNDAVALQGIEFW-----SNVCDE--------------------E 296

  Fly   311 VDIILLKGNVEEDDMVPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLS 375
            :|:.:......:....|.|...     |.:|......|.......|..|:.|      |:|:
  Fly   297 IDLAIESQEATDQGRAPQRVSK-----HYARGALQFLTPVLVEKLTKQDECD------DEDT--- 347

  Fly   376 EWNLRKCSAAALDVLANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHL 440
             |:..|.::..|.|||....::.:|.|||.:||.:....|..:::.|:..|::..|.....::.|
  Fly   348 -WSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPL 411

  Fly   441 PE-LIPYLISCLSDKKALVRSITCWTLSRYANWVVNQP-HDQYLKPLMEELLKRILDSNKRVQEA 503
            .| .:|.||..:.|...:||....||..|..:.:.... ::.||:.|:|..:|. |.|..||...
  Fly   412 VEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKS-LKSEPRVAAN 475

  Fly   504 ACSAFATLE----EEACTE---------LVPYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADS 555
            .|.||..|.    |.|.|.         |.||.|||:..|:....:                :|.
  Fly   476 VCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDR----------------SDG 524

  Fly   556 VGHHLNKPQYIDILMPPLIDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVYRRCISLI 620
            ...:|....|..::        :::|:...|                      |..|.:|...:|
  Fly   525 AQANLRCAAYQALM--------DMIKNSPLD----------------------CYLVVQRTTLVI 559

  Fly   621 EQTINQEMLCKQNQTYDHPDKERMIVALDLLSGLAEGLDRHI----------------------- 662
            .:.:||.|. .:.|..:|.|:.:......||....:.:.|.:
  Fly   560 LERLNQVMQ-METQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSS 623

  Fly   663 ---------ETLVANSNIMHLLYQCMQDVLP----------------EVRQSSFALLGDLTKACF 702
                     |..:|.|.::.||.......:|                :|..::..|.||:.:|..
  Fly   624 AGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALK 688

  Fly   703 PHVHPFMADFFPILGQNLNPDFI--SVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPN 765
            ..:.|:..:...:|..||....|  :|......|.|:|.:.:|.....|:.:||..|.:..|...
  Fly   689 DLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQT 753

  Fly   766 TP-------------KTLLE-NTAITIGRLG-----YVCPVEVAPYLP---EFVRQWCTSLRHIR 808
            ..             :::|| .|.|..|..|     :...:.:.|:|.   .|::      |..:
  Fly   754 DANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIK------RIAQ 812

  Fly   809 DNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASWVNPPEDLHQMIQKILHGFKTQ 866
            :.|..||        :..:.||.:.|   .|.:....:.|..|...:.|.:..|.:::
  Fly   813 EGDVSDS--------MLASAAGFIGD---LCTSFGPRLYPLLDDAIITQFLAEGKRSK 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_477368.1	KAP95	22..754	CDD:227540	162/822 (20%)
		HEAT repeat	127..155	CDD:293787	6/29 (21%)
		HEAT repeat	172..202	CDD:293787	2/29 (7%)
		HEAT repeat	213..239	CDD:293787	4/31 (13%)
		HEAT repeat	252..281	CDD:293787	10/29 (34%)
		HEAT repeat	402..430	CDD:293787	8/27 (30%)
		HEAT repeat	442..472	CDD:293787	10/30 (33%)
		HEAT repeat	481..510	CDD:293787	12/28 (43%)
Fs(2)Ket	NP_477496.1	KAP95	17..876	CDD:227540	187/959 (19%)
		HEAT repeat	330..360	CDD:293787	8/39 (21%)
		HEAT repeat	373..401	CDD:293787	8/27 (30%)
		HEAT repeat	414..444	CDD:293787	9/29 (31%)
		HEAT repeat	457..482	CDD:293787	10/25 (40%)
		HEAT repeat	508..540	CDD:293787	7/55 (13%)