Protein Alignment Tnpo and Tnpo1

DIOPT Version :10

• Sequence 1: NP_477368.1
• Gene: Tnpo / 38721
• FlyBaseID: FBgn0024921
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001386360.1
• Gene: Tnpo1 / 309126
• RGDID: 1308372
• Length: 898
• Species: Rattus norvegicus
• Alignment Length: 892
• Identity: 662/892 - (74%)
• Similarity: 761/892 - (85%)
• Gaps: 7/892 - (0%)

  Fly     3 WEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSLSG 67
            |:|..:|||||:.:|||||||||..|..||.|||:.|:|||||||||:||||||:||||||||||
  Rat    13 WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSG 77

  Fly    68 LILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPSLC 132
            ||||||::.|.......:.::||.|||..:||:|||||||||||||||||.|.|.|||.|||.||
  Rat    78 LILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLC 142

  Fly   133 EMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIACIN 197
            .:||::|||.|||||.|||||||||||||||..|:|||||||||||::||||||||||||:||:|
  Rat   143 SLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVN 207

  Fly   198 QFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYMLLR 262
            ||||:|:|||||:|||||||||.|:.||:.|||||||..||||||||||||:|||..|:||||.|
  Rat   208 QFIISRTQALMLHIDSFIENLFALAGDEEAEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR 272

  Fly   263 TQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDMVP 327
            |||.||.|||||.||||:||||.||||||..:|.:|.||||.||:||::|||||||:||||:.:|
  Rat   273 TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDEAIP 337

  Fly   328 DREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVLAN 392
            |.|:|||||||:||  |:....|.......||||||    :|||.::|:||||||||||||||||
  Rat   338 DSEQDIRPRFHRSR--TVAQQHEEDGIEEDDDDDDE----IDDDDTISDWNLRKCSAAALDVLAN 396

  Fly   393 VFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKAL 457
            |:|::.||.:||:|||.|||.|||:||||:|.|||||||||||||.:||||||:||.||||||||
  Rat   397 VYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKAL 461

  Fly   458 VRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 522
            |||||||||||||:|||:||.|.||||||.|||||||||||||||||||||||||||||||||||
  Rat   462 VRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 526

  Fly   523 LEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDKDL 587
            |.|||.||||||||||||||||||||:||||||||||||||:||.:||||||.|||:|||:||||
  Rat   527 LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDL 591

  Fly   588 FPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCK-QNQTYDHPDKERMIVALDLL 651
            |||||||||:||||||||||||:|||:||::|:::|:.|.||.. |.:.|:.|||:.||||||||
  Rat   592 FPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPEQYEAPDKDFMIVALDLL 656

  Fly   652 SGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFPIL 716
            |||||||..:||.|||.|||:.|:||||||.:|||||||||||||||||||.||.|.:|||.|||
  Rat   657 SGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPIL 721

  Fly   717 GQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIGRL 781
            |.||||:|||||||||||||||.:::|.|.:.||.:||..|..||||||||||||||||||||||
  Rat   722 GTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRL 786

  Fly   782 GYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASWV 846
            |||||.||||.|.:|:|.||||||:||||:||||||||:|.||:|||:||:.||||||||:|||:
  Rat   787 GYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851

  Fly   847 NPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||.:||..|..|||||||.|||:||||||.:|||..|.|||...|.:
  Rat   852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_477368.1	KAP95	22..754	CDD:227540	547/732 (75%)
		HEAT repeat	127..155	CDD:293787	20/27 (74%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	18/25 (72%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT repeat	402..430	CDD:293787	20/27 (74%)
		HEAT repeat	442..472	CDD:293787	27/29 (93%)
		HEAT repeat	481..510	CDD:293787	27/28 (96%)
Tnpo1	NP_001386360.1	KAP95	32..767	CDD:227540	551/740 (74%)
		HEAT repeat	103..124	CDD:293787	16/20 (80%)
		HEAT repeat	137..165	CDD:293787	20/27 (74%)
		HEAT repeat	182..212	CDD:293787	25/29 (86%)
		HEAT repeat	223..249	CDD:293787	18/25 (72%)
		HEAT repeat	262..291	CDD:293787	21/28 (75%)
		HEAT repeat	407..431	CDD:293787	17/23 (74%)
		HEAT repeat	447..475	CDD:293787	25/27 (93%)
		HEAT repeat	488..518	CDD:293787	28/29 (97%)
		HEAT repeat	529..555	CDD:293787	23/25 (92%)
		HEAT repeat	570..601	CDD:293787	25/30 (83%)