DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and Tnpo1

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_038958071.1	Gene:	Tnpo1 / 309126	RGDID:	1308372	Length:	898	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	662/892 - (74%)
Similarity:	761/892 - (85%)	Gaps:	7/892 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSLSG 67
            |:|..:|||||:.:|||||||||..|..||.|||:.|:|||||||||:||||||:||||||||||
  Rat    13 WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSG 77

  Fly    68 LILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPSLC 132
            ||||||::.|.......:.::||.|||..:||:|||||||||||||||||.|.|.|||.|||.||
  Rat    78 LILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLC 142

  Fly   133 EMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIACIN 197
            .:||::|||.|||||.|||||||||||||||..|:|||||||||||::||||||||||||:||:|
  Rat   143 SLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVN 207

  Fly   198 QFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYMLLR 262
            ||||:|:|||||:|||||||||.|:.||:.|||||||..||||||||||||:|||..|:||||.|
  Rat   208 QFIISRTQALMLHIDSFIENLFALAGDEEAEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR 272

  Fly   263 TQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDMVP 327
            |||.||.|||||.||||:||||.||||||..:|.:|.||||.||:||::|||||||:||||:.:|
  Rat   273 TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDEAIP 337

  Fly   328 DREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVLAN 392
            |.|:|||||||:||  |:....|.......||||||    :|||.::|:||||||||||||||||
  Rat   338 DSEQDIRPRFHRSR--TVAQQHEEDGIEEDDDDDDE----IDDDDTISDWNLRKCSAAALDVLAN 396

  Fly   393 VFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKAL 457
            |:|::.||.:||:|||.|||.|||:||||:|.|||||||||||||.:||||||:||.||||||||
  Rat   397 VYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKAL 461

  Fly   458 VRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 522
            |||||||||||||:|||:||.|.||||||.|||||||||||||||||||||||||||||||||||
  Rat   462 VRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 526

  Fly   523 LEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDKDL 587
            |.|||.||||||||||||||||||||:||||||||||||||:||.:||||||.|||:|||:||||
  Rat   527 LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDL 591

  Fly   588 FPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCK-QNQTYDHPDKERMIVALDLL 651
            |||||||||:||||||||||||:|||:||::|:::|:.|.||.. |.:.|:.|||:.||||||||
  Rat   592 FPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPEQYEAPDKDFMIVALDLL 656

  Fly   652 SGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFPIL 716
            |||||||..:||.|||.|||:.|:||||||.:|||||||||||||||||||.||.|.:|||.|||
  Rat   657 SGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPIL 721

  Fly   717 GQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIGRL 781
            |.||||:|||||||||||||||.:::|.|.:.||.:||..|..||||||||||||||||||||||
  Rat   722 GTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRL 786

  Fly   782 GYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASWV 846
            |||||.||||.|.:|:|.||||||:||||:||||||||:|.||:|||:||:.||||||||:|||:
  Rat   787 GYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851

  Fly   847 NPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||.:||..|..|||||||.|||:||||||.:|||..|.|||...|.:
  Rat   852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	42/66 (64%)
		ARM	127..234	CDD:237987	84/106 (79%)
		HEAT repeat	127..155	CDD:293787	20/27 (74%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	18/25 (72%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT_2	399..507	CDD:290374	90/107 (84%)
		HEAT repeat	402..430	CDD:293787	20/27 (74%)
		HEAT_EZ	415..469	CDD:290247	46/53 (87%)
		HEAT repeat	442..472	CDD:293787	27/29 (93%)
		HEAT repeat	481..510	CDD:293787	27/28 (96%)
		HEAT repeat	670..702	CDD:293787	26/31 (84%)
		HEAT repeat	711..737	CDD:293787	22/25 (88%)
Tnpo1	XP_038958071.1	KAP95	32..767	CDD:227540	551/740 (74%)
		HEAT repeat	103..124	CDD:293787	16/20 (80%)
		HEAT repeat	137..165	CDD:293787	20/27 (74%)
		HEAT repeat	182..212	CDD:293787	25/29 (86%)
		HEAT repeat	223..249	CDD:293787	18/25 (72%)
		HEAT repeat	262..291	CDD:293787	21/28 (75%)
		HEAT repeat	407..431	CDD:293787	17/23 (74%)
		HEAT repeat	447..475	CDD:293787	25/27 (93%)
		HEAT repeat	488..518	CDD:293787	28/29 (97%)
		HEAT repeat	529..555	CDD:293787	23/25 (92%)
		HEAT repeat	570..601	CDD:293787	25/30 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	677	1.000	Domainoid score	I130
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5358
Inparanoid	1	1.050	1357	1.000	Inparanoid score	I124
OMA	1	1.010	-	-		QHG53589
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm46260
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840