DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnpo and TNPO2

DIOPT Version :9

Sequence 1:NP_001261472.1 Gene:Tnpo / 38721 FlyBaseID:FBgn0024921 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_001129668.1 Gene:TNPO2 / 30000 HGNCID:19998 Length:897 Species:Homo sapiens


Alignment Length:904 Identity:649/904 - (71%)
Similarity:761/904 - (84%) Gaps:18/904 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSL 65
            |.|:|..:||||::.:||:||||:||||..||.||::.|::||||||||:|||:||:||||||||
Human     1 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSL 65

  Fly    66 SGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPS 130
            ||||||||::.|..:..|.:.::||.|||..:||||.|||||:|||||||||.|.|..||:|||.
Human    66 SGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQ 130

  Fly   131 LCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIAC 195
            ||.:|:::|||.|||||.|||||||||:|:|||.||||||||||||||::|||.|||||||||||
Human   131 LCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIAC 195

  Fly   196 INQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYML 260
            :||||::|:||||.|||:|||:||.|:.|:|.|||||||..||||||||:|||:|||..||:|||
Human   196 VNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYML 260

  Fly   261 LRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDM 325
            .||||.||.|||||.||||:||||.|||:|||.:|.||.|:||.||:|||:|||||||:||||:.
Human   261 QRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEA 325

  Fly   326 VPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVL 390
            |||.|:||:|||||||..|:....|...|:...:||       |||.:||:||||||||||||||
Human   326 VPDSEQDIKPRFHKSRTVTLPHEAERPDGSEDAEDD-------DDDDALSDWNLRKCSAAALDVL 383

  Fly   391 ANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKK 455
            ||||||:.||.:||:||..|||.|||:||||:|.||||||||||||:.:||||||:||.||||||
Human   384 ANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKK 448

  Fly   456 ALVRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELV 520
            ||||||.||||||||:|||:||.|.:|||||.||||||||.||||||||||||||||||||||||
Human   449 ALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELV 513

  Fly   521 PYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDK 585
            |||.|||.||||||.|||||||||||||:||||||||||||:|:||..||||||.|||.|||:||
Human   514 PYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDK 578

  Fly   586 DLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCKQN-QTYDHPDKERMIVALD 649
            |||||||||||:||||||||||||:|||:||::|:::|:.|.|:..|: :.|:.|||:.||||||
Human   579 DLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALD 643

  Fly   650 LLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFP 714
            |||||||||..|:|.|||.||||.||:|||||.:|||||||||||||||||||.||.|.:|:|.|
Human   644 LLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMP 708

  Fly   715 ILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENT----- 774
            |||.||||:|||||||||||||||||::|.|.:.|:::||::|..|||||||||||||||     
Human   709 ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTS 773

  Fly   775 -----AITIGRLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVAD 834
                 ||||||||||||.||||.|.:|:|.||||||:||||:||||||||:|.||.|||.|||.|
Human   774 PSAIPAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQD 838

  Fly   835 FIFFCDAIASWVNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            |||||||:||||:|.:||..|..|||||||.||||:||::|.|||||.|.|||...|.:
Human   839 FIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEDNWQQFSEQFPPLLKERLAAFYGV 897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnpoNP_001261472.1 IBN_N 32..99 CDD:281761 40/66 (61%)
ARM 127..234 CDD:237987 80/106 (75%)
HEAT repeat 127..155 CDD:293787 19/27 (70%)
HEAT repeat 172..202 CDD:293787 25/29 (86%)
HEAT repeat 213..239 CDD:293787 16/25 (64%)
HEAT repeat 252..281 CDD:293787 21/28 (75%)
HEAT_2 399..507 CDD:290374 85/107 (79%)
HEAT repeat 402..430 CDD:293787 19/27 (70%)
HEAT_EZ 415..469 CDD:290247 44/53 (83%)
HEAT repeat 442..472 CDD:293787 26/29 (90%)
HEAT repeat 481..510 CDD:293787 25/28 (89%)
HEAT repeat 670..702 CDD:293787 27/31 (87%)
HEAT repeat 711..737 CDD:293787 21/25 (84%)
TNPO2NP_001129668.1 HEAT 1. /evidence=ECO:0000250|UniProtKB:Q92973 9..36 17/26 (65%)
KAP95 22..756 CDD:227540 538/740 (73%)
HEAT 2. /evidence=ECO:0000250|UniProtKB:Q92973 41..79 30/37 (81%)
HEAT 3. /evidence=ECO:0000250|UniProtKB:Q92973 88..121 24/32 (75%)
HEAT repeat 93..114 CDD:293787 15/20 (75%)
HEAT 4. /evidence=ECO:0000250|UniProtKB:Q92973 127..164 26/36 (72%)
HEAT repeat 127..155 CDD:293787 19/27 (70%)
HEAT repeat 165..202 CDD:293787 32/36 (89%)
HEAT 5. /evidence=ECO:0000250|UniProtKB:Q92973 171..201 25/29 (86%)
HEAT repeat 213..239 CDD:293787 16/25 (64%)
HEAT 6. /evidence=ECO:0000250|UniProtKB:Q92973 214..241 18/26 (69%)
HEAT repeat 252..281 CDD:293787 21/28 (75%)
HEAT 7. /evidence=ECO:0000250|UniProtKB:Q92973 253..280 19/26 (73%)
HEAT 8. /evidence=ECO:0000250|UniProtKB:Q92973 296..386 59/96 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 325..364 19/45 (42%)
HEAT 9. /evidence=ECO:0000250|UniProtKB:Q92973 394..422 18/27 (67%)
HEAT 10. /evidence=ECO:0000250|UniProtKB:Q92973 434..461 23/26 (88%)
HEAT repeat 436..464 CDD:293787 24/27 (89%)
HEAT 11. /evidence=ECO:0000250|UniProtKB:Q92973 475..508 30/32 (94%)
HEAT repeat 477..507 CDD:293787 27/29 (93%)
HEAT 12. /evidence=ECO:0000250|UniProtKB:Q92973 516..549 28/32 (88%)
HEAT repeat 518..544 CDD:293787 22/25 (88%)
HEAT 13. /evidence=ECO:0000250|UniProtKB:Q92973 557..595 30/37 (81%)
HEAT repeat 559..590 CDD:293787 25/30 (83%)
HEAT 14. /evidence=ECO:0000250|UniProtKB:Q92973 603..654 29/50 (58%)
HEAT repeat 664..696 CDD:293787 27/31 (87%)
HEAT 15. /evidence=ECO:0000250|UniProtKB:Q92973 665..696 26/30 (87%)
HEAT 16. /evidence=ECO:0000250|UniProtKB:Q92973 704..737 27/32 (84%)
HEAT repeat 705..731 CDD:293787 21/25 (84%)
HEAT 17. /evidence=ECO:0000250|UniProtKB:Q92973 745..790 28/44 (64%)
HEAT 18. /evidence=ECO:0000250|UniProtKB:Q92973 798..831 23/32 (72%)
HEAT 19. /evidence=ECO:0000250|UniProtKB:Q92973 840..871 21/30 (70%)
HEAT 20. /evidence=ECO:0000250|UniProtKB:Q92973 874..894 12/19 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 673 1.000 Domainoid score I142
eggNOG 1 0.900 - - E1_KOG2023
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1356 1.000 Inparanoid score I136
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53589
OrthoDB 1 1.010 - - D525700at2759
OrthoFinder 1 1.000 - - FOG0001564
OrthoInspector 1 1.000 - - otm42114
orthoMCL 1 0.900 - - OOG6_101362
Panther 1 1.100 - - O PTHR10527
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R601
SonicParanoid 1 1.000 - - X877
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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