DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo and kap104

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_594385.1	Gene:	kap104 / 2542046	PomBaseID:	SPAC2F3.06c	Length:	910	Species:	Schizosaccharomyces pombe

Alignment Length:	922	Identity:	400/922 - (43%)
Similarity:	581/922 - (63%)	Gaps:	48/922 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSLSG 67
            |..|.:.|.::..::|.|.|.::.|:.|....||:....||.||||..:|..........||.:|
pombe     6 WVLQEQVLVELSEVIKNSLSENSQTRNAALNLLEKAKDIPDLNNYLTCILINATELSVSIRSAAG 70

  Fly    68 LILKNNIRM----HGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLL 128
            |:||||:|:    .|:.||.  ::|.|...::.:.|...|||...|.:||||.|..|:..||::|
pombe    71 LLLKNNVRVSSLESGSGLQS--LDYTKSTVIRGLCDPEQLIRGISGNVITTIISRWGISTWPEVL 133

  Fly   129 PSLCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALN--RPLNIMIPKFLEYFKHSSPKIRSH 191
            |.|.|||.:......|||||||.|||||||:.|| ...|  |||:.|||:|:|..:|.:||||:.
pombe   134 PQLMEMLSSPASTTQEGAFSALTKICEDSAQELD-RDFNGTRPLDFMIPRFIELARHENPKIRTD 197

  Fly   192 AIACINQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQII 256
            |:.|:|||::.:||:|..:||:|:|..:.|::|....||||||..||.||:||.|::.|.:..|:
pombe   198 ALFCLNQFVLIQSQSLYAHIDTFLETCYALATDVSPNVRKNVCQALVYLLDVRPDKIAPSLGSIV 262

  Fly   257 EYMLLRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVE 321
            ||||..|||:|:.|||||.||||::|||......|.|||.::.|:|::||.||::|::|| ||..
pombe   263 EYMLYSTQDSDQNVALEACEFWLAIAEQPDLCSALGPYLDKIVPMLLQGMVYSDMDLLLL-GNDA 326

  Fly   322 EDDMVPDREEDIRPRFHKSRAH-TIRS----TQEGGAGATG------DDDDDEFEDGMDDDSSLS 375
            :|..|.||||||||:..|.::. |:.:    ||:|.:.|..      |:|||||:   :||.:..
pombe   327 DDYDVEDREEDIRPQHAKGKSRITLNTQGPITQQGSSNADADELEDEDEDDDEFD---EDDDAFM 388

  Fly   376 EWNLRKCSAAALDVLANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHL 440
            :||||||||||||||::.:::..|.::||.||::|..::|.::|:||||:||||||||.||:|:|
pombe   389 DWNLRKCSAAALDVLSSFWKQRLLEIILPHLKQSLTSEDWKVQEAGVLAVGAIAEGCMDGMVQYL 453

  Fly   441 PELIPYLISCLSDKKALVRSITCWTLSRYANWV----VNQPHDQYLKPLMEELLKRILDSNKRVQ 501
            |||.||.:|.|..||.|||:||||||.||:.|.    ..:...:|..||::.||:.::|:||:||
pombe   454 PELYPYFLSLLDSKKPLVRTITCWTLGRYSKWASCLESEEDRQKYFVPLLQGLLRMVVDNNKKVQ 518

  Fly   502 EAACSAFATLEEEACTELVPYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYI 566
            ||.|||||.|||:|...||||||.||..|.|||.|||.||:|||||||.||||.||..||..:||
pombe   519 EAGCSAFAILEEQAGPSLVPYLEPILTNLAFAFQKYQRKNVLILYDAVQTLADYVGSALNDKRYI 583

  Fly   567 DILMPPLIDKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCK 631
            ::|:.||:.||:::.|||.:||||.|||||:|.||:.||.|:....|.|...::..|:......:
pombe   584 ELLITPLLQKWSMIPDDDPNLFPLFECLSSVAVALRDGFAPFAAETYARTFRILRNTLYLITTAQ 648

  Fly   632 QNQTYDHPDKERMIVALDLLSGLAEGLDRHIETLVANSN--IMHLLYQCMQDVLPEVRQSSFALL 694
            .:.|.|.||::.::..|||:||:.:.|...:..|:|.::  :..::..|.:|.:||||||::|||
pombe   649 NDPTVDVPDRDFLVTTLDLVSGIIQALGSQVSPLLAQADPPLGQIIGICAKDEVPEVRQSAYALL 713

  Fly   695 GDLTKACFPHVHPF----MADFFPILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLS 755
            ||:...||..:.|:    :.|..|.:  .|....:|..|||.|:.||:.::||::.:|:::.:|.
pombe   714 GDMCMYCFDQIRPYCDALLVDMLPQM--QLPLLHVSASNNAIWSAGEMALQLGKDMQQWVKPLLE 776

  Fly   756 DLFIIINRPNTPKTLLENTAITIGRLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGM 820
            .|..|:....:..|:|||.||||||||...|..|||:|..|.:.|...::.:.:|:||||||||.
pombe   777 RLICILKSKKSNTTVLENVAITIGRLGVYNPELVAPHLELFYQPWFEIIKTVGENEEKDSAFRGF 841

  Fly   821 CHMITVNPAGVVADFIFFCDAIASWVNPPEDLHQMIQKILHG----FKTQVGEENWRRFVEQFPP 881
            |:::..||..:......|...:|.:.||..:|..|.||||.|    |.   |:.:|     |..|
pombe   842 CNILACNPQALSYLLPMFVLCVAEYENPSAELRDMFQKILQGSVELFN---GKASW-----QASP 898

  Fly   882 TLAERLTTMYNI 893
            .:..::...|.:
pombe   899 EVLAQIQAQYGV 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	23/70 (33%)
		ARM	127..234	CDD:237987	54/108 (50%)
		HEAT repeat	127..155	CDD:293787	15/27 (56%)
		HEAT repeat	172..202	CDD:293787	15/29 (52%)
		HEAT repeat	213..239	CDD:293787	11/25 (44%)
		HEAT repeat	252..281	CDD:293787	18/28 (64%)
		HEAT_2	399..507	CDD:290374	58/111 (52%)
		HEAT repeat	402..430	CDD:293787	14/27 (52%)
		HEAT_EZ	415..469	CDD:290247	36/53 (68%)
		HEAT repeat	442..472	CDD:293787	19/29 (66%)
		HEAT repeat	481..510	CDD:293787	16/28 (57%)
		HEAT repeat	670..702	CDD:293787	13/33 (39%)
		HEAT repeat	711..737	CDD:293787	8/25 (32%)
kap104	NP_594385.1	IBN_N	34..>78	CDD:296344	17/43 (40%)
		HEAT repeat	51..83	CDD:293787	11/31 (35%)
		KAP95	65..791	CDD:227540	335/734 (46%)
		HEAT repeat	93..120	CDD:293787	9/26 (35%)
		ARM	130..243	CDD:237987	57/113 (50%)
		HEAT repeat	132..160	CDD:293787	15/27 (56%)
		HEAT repeat	178..208	CDD:293787	15/29 (52%)
		HEAT repeat	219..245	CDD:293787	11/25 (44%)
		HEAT repeat	258..283	CDD:293787	14/24 (58%)
		HEAT repeat	415..443	CDD:293787	14/27 (52%)
		HEAT_EZ	428..482	CDD:290247	36/53 (68%)
		HEAT repeat	455..485	CDD:293787	19/29 (66%)
		HEAT repeat	498..527	CDD:293787	16/28 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	329	1.000	Domainoid score	I212
eggNOG	1	0.900	-	-		E1_KOG2023
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5358
Inparanoid	1	1.050	739	1.000	Inparanoid score	I85
OMA	1	1.010	-	-		QHG53589
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	1	1.000	-	-		otm47395
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	1	1.100	-	-	LDO	PTHR10527
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R601
SonicParanoid	1	1.000	-	-		X877
TreeFam	1	0.960	-	-
	14	13.860