DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnpo and Tnpo1

DIOPT Version :10

Sequence 1:NP_477368.1 Gene:Tnpo / 38721 FlyBaseID:FBgn0024921 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_848831.2 Gene:Tnpo1 / 238799 MGIID:2681523 Length:898 Species:Mus musculus


Alignment Length:892 Identity:662/892 - (74%)
Similarity:761/892 - (85%) Gaps:7/892 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 WEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSLSG 67
            |:|..:|||||:.:|||||||||..|..||.|||:.|:|||||||||:||||||:||||||||||
Mouse    13 WKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSG 77

  Fly    68 LILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPSLC 132
            ||||||::.|.......:.::||.|||..:||:|||||||||||||||||.|.|.|||.|||.||
Mouse    78 LILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLC 142

  Fly   133 EMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIACIN 197
            .:||::|||.|||||.|||||||||||||||..|:|||||||||||::||||||||||||:||:|
Mouse   143 SLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVN 207

  Fly   198 QFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYMLLR 262
            ||||:|:|||||:|||||||||.|:.||:.|||||||..||||||||||||:|||..|:||||.|
Mouse   208 QFIISRTQALMLHIDSFIENLFALAGDEEAEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQR 272

  Fly   263 TQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDMVP 327
            |||.||.|||||.||||:||||.||||||..:|.:|.||||.||:||::|||||||:||||:.:|
Mouse   273 TQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIP 337

  Fly   328 DREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVLAN 392
            |.|:|||||||:||  |:....|.......||||||    :|||.::|:||||||||||||||||
Mouse   338 DSEQDIRPRFHRSR--TVAQQHEEDGIEEEDDDDDE----IDDDDTISDWNLRKCSAAALDVLAN 396

  Fly   393 VFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKKAL 457
            |:|::.||.:||:|||.|||.|||:||||:|.|||||||||||||.:||||||:||.||||||||
Mouse   397 VYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKAL 461

  Fly   458 VRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 522
            |||||||||||||:|||:||.|.||||||.|||||||||||||||||||||||||||||||||||
Mouse   462 VRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY 526

  Fly   523 LEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDKDL 587
            |.|||.||||||||||||||||||||:||||||||||||||:||.:||||||.|||:|||:||||
Mouse   527 LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDL 591

  Fly   588 FPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCK-QNQTYDHPDKERMIVALDLL 651
            |||||||||:||||||||||||:|||:||::|:::|:.|.||.. |.:.|:.|||:.||||||||
Mouse   592 FPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPEQYEAPDKDFMIVALDLL 656

  Fly   652 SGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFPIL 716
            |||||||..:||.|||.|||:.|:||||||.:|||||||||||||||||||.||.|.:|||.|||
Mouse   657 SGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPIL 721

  Fly   717 GQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIGRL 781
            |.||||:|||||||||||||||.:::|.|.:.||.:||..|..||||||||||||||||||||||
Mouse   722 GTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRL 786

  Fly   782 GYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIASWV 846
            |||||.||||.|.:|:|.||||||:||||:||||||||:|.||:|||:||:.||||||||:|||:
Mouse   787 GYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWI 851

  Fly   847 NPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||.:||..|..|||||||.|||:||||||.:|||..|.|||...|.:
Mouse   852 NPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnpoNP_477368.1 KAP95 22..754 CDD:227540 547/732 (75%)
HEAT repeat 127..155 CDD:293787 20/27 (74%)
HEAT repeat 172..202 CDD:293787 25/29 (86%)
HEAT repeat 213..239 CDD:293787 18/25 (72%)
HEAT repeat 252..281 CDD:293787 21/28 (75%)
HEAT repeat 402..430 CDD:293787 20/27 (74%)
HEAT repeat 442..472 CDD:293787 27/29 (93%)
HEAT repeat 481..510 CDD:293787 27/28 (96%)
Tnpo1NP_848831.2 HEAT 1. /evidence=ECO:0000250|UniProtKB:Q92973 19..46 18/26 (69%)
KAP95 32..767 CDD:227540 551/740 (74%)
HEAT 2. /evidence=ECO:0000250|UniProtKB:Q92973 51..89 32/37 (86%)
HEAT 3. /evidence=ECO:0000250|UniProtKB:Q92973 98..131 25/32 (78%)
HEAT repeat 103..124 CDD:293787 16/20 (80%)
HEAT 4. /evidence=ECO:0000250|UniProtKB:Q92973 137..174 29/36 (81%)
HEAT repeat 137..165 CDD:293787 20/27 (74%)
HEAT 5. /evidence=ECO:0000250|UniProtKB:Q92973 181..211 25/29 (86%)
HEAT repeat 182..212 CDD:293787 25/29 (86%)
HEAT repeat 223..249 CDD:293787 18/25 (72%)
HEAT 6. /evidence=ECO:0000250|UniProtKB:Q92973 224..251 19/26 (73%)
HEAT repeat 262..291 CDD:293787 21/28 (75%)
HEAT 7. /evidence=ECO:0000250|UniProtKB:Q92973 263..290 19/26 (73%)
HEAT 8. /evidence=ECO:0000250|UniProtKB:Q92973 306..397 59/96 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..374 12/32 (38%)
HEAT 9. /evidence=ECO:0000250|UniProtKB:Q92973 405..433 19/27 (70%)
HEAT repeat 407..431 CDD:293787 17/23 (74%)
HEAT 10. /evidence=ECO:0000250|UniProtKB:Q92973 445..472 24/26 (92%)
HEAT repeat 447..475 CDD:293787 25/27 (93%)
HEAT 11. /evidence=ECO:0000250|UniProtKB:Q92973 486..519 31/32 (97%)
HEAT repeat 488..518 CDD:293787 28/29 (97%)
HEAT 12. /evidence=ECO:0000250|UniProtKB:Q92973 527..560 29/32 (91%)
HEAT repeat 529..555 CDD:293787 23/25 (92%)
HEAT 13. /evidence=ECO:0000250|UniProtKB:Q92973 568..606 30/37 (81%)
HEAT repeat 570..601 CDD:293787 25/30 (83%)
HEAT 14. /evidence=ECO:0000250|UniProtKB:Q92973 614..665 30/50 (60%)
HEAT 15. /evidence=ECO:0000250|UniProtKB:Q92973 676..707 25/30 (83%)
HEAT 16. /evidence=ECO:0000250|UniProtKB:Q92973 715..748 26/32 (81%)
HEAT 17. /evidence=ECO:0000250|UniProtKB:Q92973 756..791 28/34 (82%)
HEAT 18. /evidence=ECO:0000250|UniProtKB:Q92973 799..832 23/32 (72%)
HEAT 19. /evidence=ECO:0000250|UniProtKB:Q92973 841..872 21/30 (70%)
HEAT 20. /evidence=ECO:0000250|UniProtKB:Q92973 875..895 13/19 (68%)

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