Protein Alignment Tnpo and Tnpo2

DIOPT Version :10

• Sequence 1: NP_477368.1
• Gene: Tnpo / 38721
• FlyBaseID: FBgn0024921
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_663365.3
• Gene: Tnpo2 / 212999
• MGIID: 2384849
• Length: 897
• Species: Mus musculus
• Alignment Length: 904
• Identity: 650/904 - (71%)
• Similarity: 763/904 - (84%)
• Gaps: 18/904 - (1%)

  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSL 65
            |.|:|..:||||::.:||:||||:||||..||.||::.|::||||||||:|||:||:||||||||
Mouse     1 MDWQPDEQGLQQVLQLLKDSQSPNTATQRIVQDKLKQLNQFPDFNNYLIFVLTRLKSEDEPTRSL 65

  Fly    66 SGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPS 130
            ||||||||::.|..:..|.:.::||.|||..:||||.|||||:|||||||||.|.|..||:|||.
Mouse    66 SGLILKNNVKAHYQSFPPPVADFIKQECLNNIGDASSLIRATIGILITTIASKGELQMWPELLPQ 130

  Fly   131 LCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIAC 195
            ||.:|:::|||.|||||.|||||||||:|:|||.||||||||||||||::|||.|||||||||||
Mouse   131 LCNLLNSEDYNTCEGAFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIAC 195

  Fly   196 INQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYML 260
            :||||::|:||||.|||:|||:||.|:.|:|.|||||||..||||||||:|||:|||..||:|||
Mouse   196 VNQFIMDRAQALMDNIDTFIEHLFALAVDDDPEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYML 260

  Fly   261 LRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDM 325
            .||||.||.|||||.||||:||||.|||:|||.:|.||.|:||.||:|||:|||||||:||||:.
Mouse   261 QRTQDHDENVALEACEFWLTLAEQPICKEVLASHLVQLIPILVNGMKYSEIDIILLKGDVEEDEA 325

  Fly   326 VPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVL 390
            |||.|:||:|||||||  |:..|.|.....:.:|.:|:     |||.:||:||||||||||||||
Mouse   326 VPDSEQDIKPRFHKSR--TVTLTHEAERPDSSEDAEDD-----DDDDALSDWNLRKCSAAALDVL 383

  Fly   391 ANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKK 455
            ||||||:.||.:||:||..|||.|||:||||:|.||||||||||||:.:||||||:||.||||||
Mouse   384 ANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLSDKK 448

  Fly   456 ALVRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELV 520
            ||||||.||||||||:|||:||.|.:|||||.||||||||.||||||||||||||||||||||||
Mouse   449 ALVRSIACWTLSRYAHWVVSQPPDMHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELV 513

  Fly   521 PYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDK 585
            |||.|||.||||||.|||||||||||||:||||||||||||:|:||..||||||.|||.|||:||
Mouse   514 PYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDK 578

  Fly   586 DLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCKQN-QTYDHPDKERMIVALD 649
            |||||||||||:||||||||||||:|||:||::|:::|:.|.|:..|: :.|:.|||:.||||||
Mouse   579 DLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYTQHPEQYEAPDKDFMIVALD 643

  Fly   650 LLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFP 714
            |||||||||..|:|.|||.||||.||:|||||.:|||||||||||||||||||.||.|.:|:|.|
Mouse   644 LLSGLAEGLGGHVEQLVARSNIMTLLFQCMQDSMPEVRQSSFALLGDLTKACFIHVKPCIAEFMP 708

  Fly   715 ILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENT----- 774
            |||.||||:|||||||||||||||||::|.|.:.|:::||::|..|||||||||||||||
Mouse   709 ILGTNLNPEFISVCNNATWAIGEICMQMGAEMQPYVQMVLNNLVEIINRPNTPKTLLENTGRLTS 773

  Fly   775 -----AITIGRLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVAD 834
                 ||||||||||||.||||.|.:|:|.||||||:||||:||||||||:|.||.|||.|||.|
Mouse   774 PSAIPAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICMMIGVNPGGVVQD 838

  Fly   835 FIFFCDAIASWVNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            |||||||:||||:|.:||..|..|||||||.|||||||::|.|||||.|.|||...|.:
Mouse   839 FIFFCDAVASWVSPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPLLKERLAAFYGV 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_477368.1	KAP95	22..754	CDD:227540	534/732 (73%)
		HEAT repeat	127..155	CDD:293787	19/27 (70%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	16/25 (64%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT repeat	402..430	CDD:293787	19/27 (70%)
		HEAT repeat	442..472	CDD:293787	26/29 (90%)
		HEAT repeat	481..510	CDD:293787	25/28 (89%)
Tnpo2	NP_663365.3	HEAT 7. /evidence=ECO:0000250|UniProtKB:Q92973	253..280		19/26 (73%)
		HEAT 8. /evidence=ECO:0000250|UniProtKB:Q92973	296..386		59/96 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..363		4/23 (17%)
		HEAT 9. /evidence=ECO:0000250|UniProtKB:Q92973	394..422		18/27 (67%)
		HEAT 10. /evidence=ECO:0000250|UniProtKB:Q92973	434..461		23/26 (88%)
		HEAT repeat	436..464	CDD:293787	24/27 (89%)
		HEAT 11. /evidence=ECO:0000250|UniProtKB:Q92973	475..508		30/32 (94%)
		HEAT repeat	477..507	CDD:293787	27/29 (93%)
		HEAT 12. /evidence=ECO:0000250|UniProtKB:Q92973	516..549		28/32 (88%)
		HEAT repeat	518..544	CDD:293787	22/25 (88%)
		HEAT 13. /evidence=ECO:0000250|UniProtKB:Q92973	557..595		30/37 (81%)
		HEAT repeat	559..590	CDD:293787	25/30 (83%)
		HEAT 14. /evidence=ECO:0000250|UniProtKB:Q92973	603..654		29/50 (58%)
		HEAT repeat	664..696	CDD:293787	27/31 (87%)
		HEAT 15. /evidence=ECO:0000250|UniProtKB:Q92973	665..696		26/30 (87%)
		HEAT 16. /evidence=ECO:0000250|UniProtKB:Q92973	704..737		27/32 (84%)
		HEAT repeat	705..731	CDD:293787	21/25 (84%)
		HEAT 18. /evidence=ECO:0000250|UniProtKB:Q92973	798..831		23/32 (72%)
		HEAT 19. /evidence=ECO:0000250|UniProtKB:Q92973	840..871		21/30 (70%)
		HEAT 20. /evidence=ECO:0000250|UniProtKB:Q92973	874..894		13/19 (68%)
		HEAT 1. /evidence=ECO:0000250|UniProtKB:Q92973	9..36		17/26 (65%)
		KAP95	22..756	CDD:227540	538/740 (73%)
		HEAT 2. /evidence=ECO:0000250|UniProtKB:Q92973	41..79		30/37 (81%)
		HEAT 3. /evidence=ECO:0000250|UniProtKB:Q92973	88..121		24/32 (75%)
		HEAT repeat	93..114	CDD:293787	15/20 (75%)
		HEAT 4. /evidence=ECO:0000250|UniProtKB:Q92973	127..164		26/36 (72%)
		HEAT repeat	127..155	CDD:293787	19/27 (70%)
		HEAT repeat	165..202	CDD:293787	32/36 (89%)
		HEAT 5. /evidence=ECO:0000250|UniProtKB:Q92973	171..201		25/29 (86%)
		HEAT repeat	213..239	CDD:293787	16/25 (64%)
		HEAT 6. /evidence=ECO:0000250|UniProtKB:Q92973	214..241		18/26 (69%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)