Protein Alignment Tnpo and Tnpo

DIOPT Version :10

• Sequence 1: NP_477368.1
• Gene: Tnpo / 38721
• FlyBaseID: FBgn0024921
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: XP_315921.4
• Gene: Tnpo / 1276558
• VectorBaseID: AGAMI1_015114
• Length: 904
• Species: Anopheles gambiae
• Alignment Length: 905
• Identity: 706/905 - (78%)
• Similarity: 808/905 - (89%)
• Gaps: 13/905 - (1%)

  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSL 65
            |:||||.:||.|||.:||:|||.|...|.|||:||||.|:|||||||||||||||.:||||||||
Mosquito     1 MSWEPQPDGLSQIITLLKQSQSTDNMVQRAVQLKLEELNQYPDFNNYLIYVLTKLTSEDEPTRSL 65

  Fly    66 SGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPS 130
            ||||||||||:|||.|||.|:||||.|||.|:||.|||||||.||||||||:.|||.|||:|||:
Mosquito    66 SGLILKNNIRIHGTELQPAIIEYIKQECLMALGDPSPLIRATAGILITTIANKGGLQNWPELLPT 130

  Fly   131 LCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIAC 195
            ||:|||:|||:||||||.||||||||||::|||:||||||||||||||::|:||||||||:||||
Mosquito   131 LCDMLDSQDYSVCEGAFGALQKICEDSADVLDSSALNRPLNIMIPKFLQFFRHSSPKIRSNAIAC 195

  Fly   196 INQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYML 260
            ||||||||:||||::||:|||||||||||:|.|||||||.||||||:||||||||||:.||||||
Mosquito   196 INQFIINRTQALMVHIDTFIENLFHLSSDDDREVRKNVCRGLVMLLDVRMDRLMPHMNSIIEYML 260

  Fly   261 LRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDM 325
            :||||:|| .:|||.||||:||||||||:||.|:|.:|.|||||||:||::|||:|||:||||:|
Mosquito   261 IRTQDSDE-TSLEACEFWLTLAEQSICKEVLTPHLPRLVPVLVRGMKYSDIDIIILKGDVEEDEM 324

  Fly   326 VPDREEDIRPRFHKSRAHTIRSTQEGGA----GAT----GDDDDDEFE---DGMDDDSSLSEWNL 379
            :|||||||:|||||||.||.:.:..|||    ||.    |:|||::.:   |.|||||:||:|||
Mosquito   325 IPDREEDIKPRFHKSRTHTQKPSLGGGASGADGAVRAMEGNDDDEDIDDPYDEMDDDSNLSDWNL 389

  Fly   380 RKCSAAALDVLANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELI 444
            |||||||||||||||::|.||::||||||||||:||||||||:|||||||||||.||:.||||||
Mosquito   390 RKCSAAALDVLANVFKDDFLPILLPILKETLFHEEWVIKESGILALGAIAEGCMNGMVPHLPELI 454

  Fly   445 PYLISCLSDKKALVRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFA 509
            ||||.|||||||||||||||||||||:|||:|||||||||||:||||||||:|||||||||||||
Mosquito   455 PYLIVCLSDKKALVRSITCWTLSRYAHWVVSQPHDQYLKPLMKELLKRILDANKRVQEAACSAFA 519

  Fly   510 TLEEEACTELVPYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLI 574
            ||||||||||||||.:||.||||||.|||||||||||||:||||||||||||||:||.:||||||
Mosquito   520 TLEEEACTELVPYLGFILDTLVFAFRKYQHKNLLILYDAIGTLADSVGHHLNKPEYISMLMPPLI 584

  Fly   575 DKWNLLKDDDKDLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEMLCKQNQ-TYDH 638
            :|||.|||:|||||||||||||:||||.||||||.:||||||||||:||:||::....:. .::.
Mosquito   585 EKWNNLKDEDKDLFPLLECLSSVATALHSGFLPYSEPVYRRCISLIQQTLNQDLASTTSPGQFEQ 649

  Fly   639 PDKERMIVALDLLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFP 703
            |||:.||||||||||||||||.:||:||::||||.||||||||.:|||||||||||||||||||.
Mosquito   650 PDKDFMIVALDLLSGLAEGLDCYIESLVSSSNIMQLLYQCMQDSMPEVRQSSFALLGDLTKACFQ 714

  Fly   704 HVHPFMADFFPILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPK 768
            ||||.:|||.||||.||||::||||||||||||||.:||.|:||.||.:||:.|..|||..||||
Mosquito   715 HVHPHIADFLPILGHNLNPEYISVCNNATWAIGEISIKLMEDTKPYIPMVLAPLIEIINNTNTPK 779

  Fly   769 TLLENTAITIGRLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVA 833
            ||||||||||||||.||||||||.|.:||||||:|||:||||:||||||||||.||||||.|||.
Mosquito   780 TLLENTAITIGRLGLVCPVEVAPSLQQFVRQWCSSLRNIRDNEEKDSAFRGMCQMITVNPVGVVP 844

  Fly   834 DFIFFCDAIASWVNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||||||||.|||:.|.:|||:|:||||||||.|||||||.||||||||.|:|||..||:|
Mosquito   845 DFIFFCDAAASWMTPKKDLHEMLQKILHGFKMQVGEENWARFVEQFPPQLSERLAVMYSI 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_477368.1	KAP95	22..754	CDD:227540	581/743 (78%)
		HEAT repeat	127..155	CDD:293787	22/27 (81%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	21/25 (84%)
		HEAT repeat	252..281	CDD:293787	20/28 (71%)
		HEAT repeat	402..430	CDD:293787	24/27 (89%)
		HEAT repeat	442..472	CDD:293787	28/29 (97%)
		HEAT repeat	481..510	CDD:293787	26/28 (93%)
Tnpo	XP_315921.4	KAP95	11..781	CDD:227540	609/781 (78%)
		HEAT repeat	127..155	CDD:293787	22/27 (81%)
		HEAT repeat	172..204	CDD:293787	27/31 (87%)
		HEAT repeat	213..239	CDD:293787	21/25 (84%)
		HEAT repeat	412..440	CDD:293787	22/27 (81%)
		HEAT repeat	452..482	CDD:293787	27/29 (93%)
		HEAT repeat	491..520	CDD:293787	27/28 (96%)
		HEAT repeat	576..607	CDD:293787	26/30 (87%)
		HEAT repeat	681..713	CDD:293787	26/31 (84%)
		HEAT repeat	722..748	CDD:293787	19/25 (76%)