Protein Alignment Tnpo and tnpo2b

DIOPT Version :10

• Sequence 1: NP_477368.1
• Gene: Tnpo / 38721
• FlyBaseID: FBgn0024921
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: XP_021333077.1
• Gene: tnpo2b / 100005536
• ZFINID: ZDB-GENE-211110-1
• Length: 889
• Species: Danio rerio
• Alignment Length: 894
• Identity: 657/894 - (73%)
• Similarity: 761/894 - (85%)
• Gaps: 6/894 - (0%)

  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSL 65
            |.|:|..:||||::.:||:|||||||||.|||.|||:.|::||||||||:|||.||:||||||||
Zfish     1 MEWQPDEQGLQQVLQLLKDSQSPDTATQRAVQEKLEQLNQFPDFNNYLIFVLTSLKSEDEPTRSL 65

  Fly    66 SGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPS 130
            ||||||||::.|.....|.:.::||.|||..:||.|||||||:|||||||||.|.|..||:|||.
Zfish    66 SGLILKNNVKAHYQNFPPAVADFIKRECLNNIGDPSPLIRATIGILITTIASKGELQTWPELLPQ 130

  Fly   131 LCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIAC 195
            ||.:|:::|||.|||:|.|||||||||:|:|||.||||||||||||||::|||.|||||||||||
Zfish   131 LCNLLNSEDYNTCEGSFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIAC 195

  Fly   196 INQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYML 260
            :|||||.|:||||.|||:|||:||.|::|||.|||||||..||||||||:|||:|||..||:|||
Zfish   196 VNQFIIGRAQALMDNIDTFIESLFALATDEDCEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYML 260

  Fly   261 LRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDM 325
            .||||.||.|||||.||||:||||.|||:.|:.:|.||.|:||.||:|||:|||||||:|||||.
Zfish   261 QRTQDADENVALEACEFWLTLAEQPICKEALSGHLVQLIPILVNGMKYSEIDIILLKGDVEEDDT 325

  Fly   326 VPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVL 390
            :||.|:||:|||||||..|::  .|||.|..|:|.|   ||..|||.:||:||||||||||||||
Zfish   326 IPDSEQDIKPRFHKSRTVTLQ--HEGGEGEEGEDID---EDEDDDDDTLSDWNLRKCSAAALDVL 385

  Fly   391 ANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKK 455
            |||||::.||.:||:||..|||.:|||||||:|.||||||||||||:.:||||||:||.||.|||
Zfish   386 ANVFRDELLPHLLPLLKGLLFHPDWVIKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLCDKK 450

  Fly   456 ALVRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELV 520
            ||||||.||||||||:|||:||.|.:|||||.||||||||.||||||||||||||||||||||||
Zfish   451 ALVRSIACWTLSRYAHWVVSQPPDAHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELV 515

  Fly   521 PYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDK 585
            |||.|||.||||||.|||||||||||||:||||||||||||:|:||..||||||.|||.|||:||
Zfish   516 PYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDK 580

  Fly   586 DLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEML-CKQNQTYDHPDKERMIVALD 649
            |||||||||||:||||||||||||:|||:||::|:::|:.|.|: .:|...|:.|||:.||||||
Zfish   581 DLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYSQQPDQYEAPDKDFMIVALD 645

  Fly   650 LLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFP 714
            |||||||||..|::.|||.||||.||:|||||.:||||||||||||||||||||||.|.:|:|.|
Zfish   646 LLSGLAEGLGGHVDQLVARSNIMTLLFQCMQDTMPEVRQSSFALLGDLTKACFPHVKPCIAEFMP 710

  Fly   715 ILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIG 779
            |||.||||:|||||||||||||||||::|.|.:.|:.|||..|..||||||||||||||||||||
Zfish   711 ILGTNLNPEFISVCNNATWAIGEICMQMGVEMQPYVALVLPHLVEIINRPNTPKTLLENTAITIG 775

  Fly   780 RLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIAS 844
            |||||||.||||.|.:|:|.||||||:||||:||||||||:|.||.|||.|||.||||||||:||
Zfish   776 RLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICVMIGVNPGGVVQDFIFFCDAVAS 840

  Fly   845 WVNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||||.:||..|..|||||||.|||||||::|.|||||.|.|||:..|.:
Zfish   841 WVNPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPILKERLSACYGV 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_477368.1	KAP95	22..754	CDD:227540	540/732 (74%)
		HEAT repeat	127..155	CDD:293787	18/27 (67%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	17/25 (68%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT repeat	402..430	CDD:293787	19/27 (70%)
		HEAT repeat	442..472	CDD:293787	25/29 (86%)
		HEAT repeat	481..510	CDD:293787	25/28 (89%)
tnpo2b	XP_021333077.1	KAP95	22..758	CDD:227540	544/740 (74%)
		HEAT repeat	93..114	CDD:293787	15/20 (75%)
		HEAT repeat	127..155	CDD:293787	18/27 (67%)
		HEAT repeat	165..202	CDD:293787	32/36 (89%)
		HEAT repeat	213..239	CDD:293787	17/25 (68%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT repeat	438..466	CDD:293787	23/27 (85%)
		HEAT repeat	479..509	CDD:293787	27/29 (93%)
		HEAT repeat	520..546	CDD:293787	22/25 (88%)
		HEAT repeat	561..592	CDD:293787	25/30 (83%)
		HEAT repeat	661..695	CDD:293787	28/33 (85%)
		HEAT repeat	707..737	CDD:293787	25/29 (86%)
		HEAT repeat	748..776	CDD:293787	23/27 (85%)