DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnpo and LOC100005536

DIOPT Version :9

Sequence 1:	NP_001261472.1	Gene:	Tnpo / 38721	FlyBaseID:	FBgn0024921	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_021333077.1	Gene:	LOC100005536 / 100005536	-ID:	-	Length:	889	Species:	Danio rerio

Alignment Length:	894	Identity:	657/894 - (73%)
Similarity:	761/894 - (85%)	Gaps:	6/894 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTWEPQGEGLQQIIAILKESQSPDTATQMAVQMKLEEFNRYPDFNNYLIYVLTKLKTEDEPTRSL 65
            |.|:|..:||||::.:||:|||||||||.|||.|||:.|::||||||||:|||.||:||||||||
Zfish     1 MEWQPDEQGLQQVLQLLKDSQSPDTATQRAVQEKLEQLNQFPDFNNYLIFVLTSLKSEDEPTRSL 65

  Fly    66 SGLILKNNIRMHGTTLQPEIVEYIKHECLQAVGDASPLIRATVGILITTIASNGGLHNWPQLLPS 130
            ||||||||::.|.....|.:.::||.|||..:||.|||||||:|||||||||.|.|..||:|||.
Zfish    66 SGLILKNNVKAHYQNFPPAVADFIKRECLNNIGDPSPLIRATIGILITTIASKGELQTWPELLPQ 130

  Fly   131 LCEMLDNQDYNVCEGAFSALQKICEDSAEILDSAALNRPLNIMIPKFLEYFKHSSPKIRSHAIAC 195
            ||.:|:::|||.|||:|.|||||||||:|:|||.||||||||||||||::|||.|||||||||||
Zfish   131 LCNLLNSEDYNTCEGSFGALQKICEDSSELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIAC 195

  Fly   196 INQFIINRSQALMLNIDSFIENLFHLSSDEDHEVRKNVCHGLVMLLEVRMDRLMPHMSQIIEYML 260
            :|||||.|:||||.|||:|||:||.|::|||.|||||||..||||||||:|||:|||..||:|||
Zfish   196 VNQFIIGRAQALMDNIDTFIESLFALATDEDCEVRKNVCRALVMLLEVRIDRLIPHMHSIIQYML 260

  Fly   261 LRTQDTDEGVALEASEFWLSLAEQSICKDVLAPYLAQLAPVLVRGMRYSEVDIILLKGNVEEDDM 325
            .||||.||.|||||.||||:||||.|||:.|:.:|.||.|:||.||:|||:|||||||:|||||.
Zfish   261 QRTQDADENVALEACEFWLTLAEQPICKEALSGHLVQLIPILVNGMKYSEIDIILLKGDVEEDDT 325

  Fly   326 VPDREEDIRPRFHKSRAHTIRSTQEGGAGATGDDDDDEFEDGMDDDSSLSEWNLRKCSAAALDVL 390
            :||.|:||:|||||||..|::  .|||.|..|:|.|   ||..|||.:||:||||||||||||||
Zfish   326 IPDSEQDIKPRFHKSRTVTLQ--HEGGEGEEGEDID---EDEDDDDDTLSDWNLRKCSAAALDVL 385

  Fly   391 ANVFREDCLPVVLPILKETLFHQEWVIKESGVLALGAIAEGCMQGMIQHLPELIPYLISCLSDKK 455
            |||||::.||.:||:||..|||.:|||||||:|.||||||||||||:.:||||||:||.||.|||
Zfish   386 ANVFRDELLPHLLPLLKGLLFHPDWVIKESGILVLGAIAEGCMQGMVPYLPELIPHLIQCLCDKK 450

  Fly   456 ALVRSITCWTLSRYANWVVNQPHDQYLKPLMEELLKRILDSNKRVQEAACSAFATLEEEACTELV 520
            ||||||.||||||||:|||:||.|.:|||||.||||||||.||||||||||||||||||||||||
Zfish   451 ALVRSIACWTLSRYAHWVVSQPPDAHLKPLMTELLKRILDGNKRVQEAACSAFATLEEEACTELV 515

  Fly   521 PYLEYILKTLVFAFSKYQHKNLLILYDAVGTLADSVGHHLNKPQYIDILMPPLIDKWNLLKDDDK 585
            |||.|||.||||||.|||||||||||||:||||||||||||:|:||..||||||.|||.|||:||
Zfish   516 PYLSYILDTLVFAFGKYQHKNLLILYDAIGTLADSVGHHLNQPEYIQKLMPPLIQKWNELKDEDK 580

  Fly   586 DLFPLLECLSSIATALQSGFLPYCDPVYRRCISLIEQTINQEML-CKQNQTYDHPDKERMIVALD 649
            |||||||||||:||||||||||||:|||:||::|:::|:.|.|: .:|...|:.|||:.||||||
Zfish   581 DLFPLLECLSSVATALQSGFLPYCEPVYQRCVTLVQKTLAQAMMYSQQPDQYEAPDKDFMIVALD 645

  Fly   650 LLSGLAEGLDRHIETLVANSNIMHLLYQCMQDVLPEVRQSSFALLGDLTKACFPHVHPFMADFFP 714
            |||||||||..|::.|||.||||.||:|||||.:||||||||||||||||||||||.|.:|:|.|
Zfish   646 LLSGLAEGLGGHVDQLVARSNIMTLLFQCMQDTMPEVRQSSFALLGDLTKACFPHVKPCIAEFMP 710

  Fly   715 ILGQNLNPDFISVCNNATWAIGEICMKLGEETKQYIRLVLSDLFIIINRPNTPKTLLENTAITIG 779
            |||.||||:|||||||||||||||||::|.|.:.|:.|||..|..||||||||||||||||||||
Zfish   711 ILGTNLNPEFISVCNNATWAIGEICMQMGVEMQPYVALVLPHLVEIINRPNTPKTLLENTAITIG 775

  Fly   780 RLGYVCPVEVAPYLPEFVRQWCTSLRHIRDNDEKDSAFRGMCHMITVNPAGVVADFIFFCDAIAS 844
            |||||||.||||.|.:|:|.||||||:||||:||||||||:|.||.|||.|||.||||||||:||
Zfish   776 RLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICVMIGVNPGGVVQDFIFFCDAVAS 840

  Fly   845 WVNPPEDLHQMIQKILHGFKTQVGEENWRRFVEQFPPTLAERLTTMYNI 893
            ||||.:||..|..|||||||.|||||||::|.|||||.|.|||:..|.:
Zfish   841 WVNPKDDLRDMFYKILHGFKDQVGEENWQQFSEQFPPILKERLSACYGV 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo	NP_001261472.1	IBN_N	32..99	CDD:281761	41/66 (62%)
		ARM	127..234	CDD:237987	81/106 (76%)
		HEAT repeat	127..155	CDD:293787	18/27 (67%)
		HEAT repeat	172..202	CDD:293787	25/29 (86%)
		HEAT repeat	213..239	CDD:293787	17/25 (68%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT_2	399..507	CDD:290374	84/107 (79%)
		HEAT repeat	402..430	CDD:293787	19/27 (70%)
		HEAT_EZ	415..469	CDD:290247	44/53 (83%)
		HEAT repeat	442..472	CDD:293787	25/29 (86%)
		HEAT repeat	481..510	CDD:293787	25/28 (89%)
		HEAT repeat	670..702	CDD:293787	27/31 (87%)
		HEAT repeat	711..737	CDD:293787	21/25 (84%)
LOC100005536	XP_021333077.1	KAP95	22..758	CDD:227540	544/740 (74%)
		HEAT repeat	93..114	CDD:293787	15/20 (75%)
		HEAT repeat	127..155	CDD:293787	18/27 (67%)
		HEAT repeat	165..202	CDD:293787	32/36 (89%)
		HEAT repeat	213..239	CDD:293787	17/25 (68%)
		HEAT repeat	252..281	CDD:293787	21/28 (75%)
		HEAT repeat	438..466	CDD:293787	23/27 (85%)
		HEAT repeat	479..509	CDD:293787	27/29 (93%)
		HEAT repeat	520..546	CDD:293787	22/25 (88%)
		HEAT repeat	561..592	CDD:293787	25/30 (83%)
		HEAT repeat	661..695	CDD:293787	28/33 (85%)
		HEAT repeat	707..737	CDD:293787	25/29 (86%)
		HEAT repeat	748..776	CDD:293787	23/27 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D525700at2759
OrthoFinder	1	1.000	-	-		FOG0001564
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R601
SonicParanoid	1	1.000	-	-		X877
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850