DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and ZNF668

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001166140.1	Gene:	ZNF668 / 79759	HGNCID:	25821	Length:	642	Species:	Homo sapiens

Alignment Length:	630	Identity:	146/630 - (23%)
Similarity:	235/630 - (37%)	Gaps:	153/630 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 CAESIKRLKEMMTSQRNMPMGVFESIADDSEAPERPEE----PASFDPLLNNKLEMIDNEEDVFK 132
            |:|.:..:|....::........|.::..:..| ||..    |.::
Human    72 CSEEVAEVKPKPETEAKAEEASGEKVSGSAAKP-RPYACPLCPKAY------------------- 116

  Fly   133 LLEKVDKELEEHSRDQSEE--------------------HFSSAEHNG---------------LE 162
               |...||..|.|..:.|                    |.:|  |.|               |.
Human   117 ---KTAPELRSHGRSHTGEKPFPCPECGRRFMQPVCLRVHLAS--HAGELPFRCAHCPKAYGALS 176

  Fly   163 EEKKESEGFNSDDEQAMGQRRIANDKRKLFRLMSCSICQQKFKKQSKFEEHMKHHNDLLPFQCQE 227
            :.|....|..       |:|..|           |:.|.:.|...|.|.:|.:.|..|.|:.|
Human   177 KLKIHQRGHT-------GERPYA-----------CADCGKSFADPSVFRKHRRTHAGLRPYSC-- 221

  Fly   228 ESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSRLRLLTIHLKKVHNQARVIAPRGEQ 292
            |.|.|.:.....||.| :.:|:.:.   |.....|...|||...||.| :::|      |.:...
Human   222 ERCGKAYAELKDLRNH-ERSHTGER---PFLCSECGKSFSRSSSLTCH-QRIH------AAQKPY 275

  Fly   293 SCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYINSALKNHLLRHAGIKNYVCQYCGVR 357
            .|..||..|....:.:.|..||:||: |:.|..||:.|...|:.:.|...|.|:|.|.|:.||
Human   276 RCPACGKGFTQLSSYQSHERTHSGEK-PFLCPRCGRMFSDPSSFRRHQRAHEGVKPYHCEKCG-- 337

  Fly   358 KTTRQ--EWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIRNFACQYCGKTFGKAYA 420
            |..||  :.:.|..:||....|||..||........|:.|. :||...|.|.|:.||:.|.:..:
Human   338 KDFRQPADLAMHRRVHTGDRPFKCLQCDKTFVASWDLKRHA-LVHSGQRPFRCEECGRAFAERAS 401

  Fly   421 CKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHEKSVERALETYKQ--------VQVNGDAS 477
            ...|...|:||:...|..|.|.|:.|.||..|.:.|..|....:...::        |.|.|::|
Human   402 LTKHSRVHSGERPFHCNACGKSFVVSSSLRKHERTHRSSEAAGVPPAQELVVGLALPVGVAGESS 466

  Fly   478 ------------------------DTQVDSHQLLKVYAESV----ASIPKNPRRVEQVDVALLAG 514
                                    .......|::.:..|.|    |.:.:.|..:|.      ||
Human   467 AAPAAGAGLGDPPAGLLGLPPESGGVMATQWQVVGMTVEHVECQDAGVREAPGPLEG------AG 525

  Fly   515 TAVNPTDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQH 579
            .|.....:    :|...::|..|.:.|.::..::||.:| |.:::.|.|..|.:.|::...:::|
Human   526 EAGGEEAD----EKPPQFVCRECKETFSTMTLLRRHERS-HPELRPFPCTQCGKSFSDRAGLRKH 585

  Fly   580 EWIHTGEKPFECKTCGNRFRQVAALIRHQKVH-----DEKPAKPL 619
            ...|:..:|:.|..|...|...:.|.:|::.|     ...|.:||
Human   586 SRTHSSVRPYTCPHCPKAFLSASDLRKHERTHPVPMGTPTPLEPL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	2/8 (25%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..371	CDD:275368	7/21 (33%)
		C2H2 Zn finger	379..400	CDD:275368	5/20 (25%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)
		C2H2 Zn finger	563..583	CDD:275368	4/19 (21%)
		zf-H2C2_2	575..600	CDD:290200	6/24 (25%)
		C2H2 Zn finger	591..611	CDD:275368	5/19 (26%)
ZNF668	NP_001166140.1	COG5048	103..437	CDD:227381	103/393 (26%)
		C2H2 Zn finger	109..129	CDD:275370	6/41 (15%)
		zf-H2C2_2	121..144	CDD:290200	5/22 (23%)
		C2H2 Zn finger	137..157	CDD:275368	2/21 (10%)
		C2H2 Zn finger	165..185	CDD:275368	2/19 (11%)
		zf-H2C2_2	178..201	CDD:290200	7/40 (18%)
		C2H2 Zn finger	193..213	CDD:275368	6/19 (32%)
		C2H2 Zn finger	221..241	CDD:275368	7/22 (32%)
		zf-H2C2_2	233..258	CDD:290200	7/28 (25%)
		C2H2 Zn finger	249..269	CDD:275368	7/20 (35%)
		COG5048	271..618	CDD:227381	91/361 (25%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		zf-H2C2_2	289..313	CDD:290200	9/24 (38%)
		C2H2 Zn finger	305..325	CDD:275368	6/19 (32%)
		zf-H2C2_2	317..342	CDD:290200	9/26 (35%)
		C2H2 Zn finger	333..353	CDD:275368	7/21 (33%)
		zf-H2C2_2	345..369	CDD:290200	8/23 (35%)
		C2H2 Zn finger	361..381	CDD:275368	5/20 (25%)
		zf-H2C2_2	373..397	CDD:290200	9/24 (38%)
		C2H2 Zn finger	389..409	CDD:275368	5/19 (26%)
		zf-H2C2_2	401..425	CDD:290200	7/23 (30%)
		C2H2 Zn finger	417..437	CDD:275368	8/19 (42%)
		C2H2 Zn finger	541..561	CDD:275368	6/20 (30%)
		zf-H2C2_2	554..577	CDD:290200	7/23 (30%)
		C2H2 Zn finger	569..589	CDD:275368	4/19 (21%)
		zf-H2C2_2	582..606	CDD:290200	6/23 (26%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910