Protein Alignment CG7386 and ZNF227

DIOPT Version :10

• Sequence 1: NP_648036.1
• Gene: CG7386 / 38719
• FlyBaseID: FBgn0035691
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_872296.1
• Gene: ZNF227 / 7770
• HGNCID: 13020
• Length: 799
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 145/525 - (27%)
• Similarity: 219/525 - (41%)
• Gaps: 91/525 - (17%)

  Fly   147 DQSEEHFSSAEHNGLEEEKKES--EGFNSDDEQAMGQRRIANDKRKLFRLMSCSICQQKFKKQSK 209
            ::|..|...:.|.|.:..:.:|  :||:|.....:..|....:|.     ..|..|.:.|.:.|.
Human   307 NKSSFHSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYRTHTGEKP-----YKCEECGKCFSQSSN 366

  Fly   210 FEEHMKHHNDLLPFQCQE--------------------------ESCRKGFTTAGALRLH----- 243
            |:.|.:.|.:..|::|:|                          |.|.||||.|....:|
Human   367 FQCHQRVHTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVHT 431

  Fly   244 -----------VDYAHS------KKEDT--VPCTVEGCQLVFSRLRLLTIHLKKVHNQARVIAPR 289
                       ..::|:      ::..|  .|...|.|...|:|...|.||. :||.
Human   432 GEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF-RVHT-------- 487

  Fly   290 GEQ--SCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYINSALKNHLLRHAGIKNYVCQ 352
            ||:  .|||||..|.....::.|...||||: .:.|..|||||..:|.|:.|...|.|.|.|.|.
Human   488 GEKPYKCKECGKGFSQASNLQVHQNVHTGEK-RFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCD 551

  Fly   353 YCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIRNFACQYCGKTFGK 417
            .||...:.......|.:|||....:||..|......:..|.:|.: ||...:.:.|:.|.|:|.:
Human   552 VCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGFSWRSNLHAHQR-VHSGEKPYKCEQCDKSFSQ 615

  Fly   418 AYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIH--EKSVERALETYK-QVQVNGDASDT 479
            |...::|:..|||||..:|.||.|.|..|..|.:|.::|  ||       .|| .|...|....:
Human   616 AIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQSHQRVHTGEK-------PYKCDVCGKGFRYSS 673

  Fly   480 QVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPSCSQGFKSI 544
            |...||.        ....:.|.:.|:.....  |.::|.....:....|..::|..|.:.|...
Human   674 QFIYHQR--------GHTGEKPYKCEECGKGF--GRSLNLRHHQRVHTGEKPHICEECGKAFSLP 728

  Fly   545 GNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQVAALIRHQK 609
            .|::.|. .||.:.|.|:|..|.:.|:.|..::.|:.:||||||::|..|...||..:.|..|||
Human   729 SNLRVHL-GVHTREKLFKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTYHQK 792

  Fly   610 VHDEK 614
            ||..|
Human   793 VHTGK 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..371	CDD:275368	4/19 (21%)
		C2H2 Zn finger	379..400	CDD:275368	4/20 (20%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..555	CDD:275368	5/20 (25%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		zf-H2C2_2	575..600	CDD:463886	10/24 (42%)
		C2H2 Zn finger	591..611	CDD:275368	8/19 (42%)
ZNF227	NP_872296.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..363	CDD:463886	5/25 (20%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	382..402	CDD:275368	2/19 (11%)
		COG5048	406..779	CDD:227381	116/401 (29%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	1/19 (5%)
		C2H2 Zn finger	466..486	CDD:275368	7/20 (35%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	9/19 (47%)
		C2H2 Zn finger	550..570	CDD:275368	4/19 (21%)
		C2H2 Zn finger	578..598	CDD:275368	4/20 (20%)
		C2H2 Zn finger	606..626	CDD:275368	6/19 (32%)
		C2H2 Zn finger	634..654	CDD:275368	8/19 (42%)
		C2H2 Zn finger	662..682	CDD:275368	5/27 (19%)
		C2H2 Zn finger	690..710	CDD:275368	3/21 (14%)
		C2H2 Zn finger	718..738	CDD:275368	5/20 (25%)
		C2H2 Zn finger	746..766	CDD:275368	5/19 (26%)
		C2H2 Zn finger	774..794	CDD:275368	8/19 (42%)