Protein Alignment CG7386 and Plag1

DIOPT Version :9

• Sequence 1: NP_648036.1
• Gene: CG7386 / 38719
• FlyBaseID: FBgn0035691
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_064353.2
• Gene: Plag1 / 56711
• MGIID: 1891916
• Length: 499
• Species: Mus musculus
• Alignment Length: 254
• Identity: 71/254 - (27%)
• Similarity: 107/254 - (42%)
• Gaps: 52/254 - (20%)

  Fly   374 RNQFKCRICDYATHTKRVLESHVKIVHEKIRNFAC--QYCGKTFGKAYACKIHEMAHTGEKRCEC 436
            |..|.|::||.|.::...|:.| ...|...|.:.|  |.|.|.|...|..:.|...|:.||..:|
Mouse    31 RKNFPCQLCDKAFNSVEKLKVH-SFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKC 94

  Fly   437 KVCDKKFLHSESLNNHLKIHEKSVERALETYKQVQVNGDASDTQVDSHQLLKVYAESVASIPKNP 501
            ..|:|.|...:.|.|||..|:.:    .||:| .:..|.:.:|::...:.|.::|.:
Mouse    95 NYCEKMFHRKDHLKNHLHTHDPN----KETFK-CEECGKSYNTKLGFKRHLALHAAT-------- 146

  Fly   502 RRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHE-------KVK 559
                                       .|...|..|.|.|:|.|.:..|.|| |.       |.|
Mouse   147 ---------------------------SGDLTCKVCLQNFESTGVLLEHLKS-HAGKSSGGVKEK 183

  Fly   560 DFECRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQVAALIRH-QKVHDEKPAK 617
            ..:|..|.|||...:.|::|..:|||.|.|.|:.|..||.:...|.|| :|.|:::..|
Mouse   184 KHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLK 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	323..343	CDD:275368
		C2H2 Zn finger	351..371	CDD:275368
		C2H2 Zn finger	379..400	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..428	CDD:275368	7/21 (33%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..555	CDD:275368	9/20 (45%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
		zf-H2C2_2	575..600	CDD:290200	11/24 (46%)
		C2H2 Zn finger	591..611	CDD:275368	8/20 (40%)
Plag1	NP_064353.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		1/1 (100%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		17/53 (32%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25
		C2H2 Zn finger	36..56	CDD:275368	6/20 (30%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		65/242 (27%)
		SFP1	<58..139	CDD:227516	25/85 (29%)
		C2H2 Zn finger	64..86	CDD:275368	7/21 (33%)
		zf-H2C2_2	79..103	CDD:404364	8/23 (35%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	3/19 (16%)
		C2H2 Zn finger	152..172	CDD:275368	9/20 (45%)
		C2H2 Zn finger	187..207	CDD:275368	7/19 (37%)
		C2H2 Zn finger	215..233	CDD:275368	7/17 (41%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		71/254 (28%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		71/254 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..400
		Massively activates transcription. /evidence=ECO:0000250	384..499

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100