DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and ZNF44

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001157748.1	Gene:	ZNF44 / 51710	HGNCID:	13110	Length:	663	Species:	Homo sapiens

Alignment Length:	439	Identity:	116/439 - (26%)
Similarity:	178/439 - (40%)	Gaps:	107/439 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 CSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEG 261
            |..|.:.|...|.:..|.:.|....|::|::  |.|.|:.:|:||:| :..|:.::   |.|.:.
Human   303 CKQCSKAFPDYSSYLRHERTHTGEKPYKCKQ--CGKAFSVSGSLRVH-ERIHTGEK---PYTCKQ 361

  Fly   262 CQLVFSRLRLLTIHL-----------------------KKVHNQARVIAPRGEQSCKECGVVFRC 303
            |...|..|.....|:                       .::|.....:....|  ||:||.:...
Human   362 CGKAFCHLGSFQRHMIMHSGDGPHKCKICGKGFDFPGSARIHEGTHTLEKPYE--CKQCGKLLSH 424

  Fly   304 PVAMKKHMYTHTGEELPYPCTICGKGFYINSALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHI 368
            ..:.::||..|||:. |:.||:|||.|...|..:.|...|.|.|.|.|:.||....|.....||.
Human   425 RSSFRRHMMAHTGDG-PHKCTVCGKAFDSPSVFQRHERTHTGEKPYECKQCGKAFRTSSSLRKHE 488

  Fly   369 LIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIRNFACQYCGKTFGK-AYACKIHEMAHTGEK 432
            ..||....:||: |..|.......:|| :..|.:...:.|:.|||.|.. .|.|: ||..|:.||
Human   489 TTHTGEQPYKCK-CGKAFSDLFSFQSH-ETTHSEEEPYECKECGKAFSSFKYFCR-HERTHSEEK 550

  Fly   433 RCECKVCDKKFLHSESLNNHLKIHEKSVERALETYKQVQVNGDASDTQVDSHQLLKVYAESVASI 497
            ..||::|.|.|    |..::||.||:                        :|
Human   551 SYECQICGKAF----SRFSYLKTHER------------------------TH------------- 574

  Fly   498 PKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDFE 562
                             ||..|            |.|..|.:.|.....:.||.:: |...:.:|
Human   575 -----------------TAEKP------------YECKQCRKAFFWPSFLLRHERT-HTGERPYE 609

  Fly   563 CRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQVAALIRHQKVH 611
            |:.|.:.|:.|...::||..||||||:|||.||..|..:::..||::.|
Human   610 CKHCGKAFSRSSFCREHERTHTGEKPYECKECGKAFSSLSSFNRHKRTH 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..400	CDD:275368	5/20 (25%)
		C2H2 Zn finger	408..428	CDD:275368	9/20 (45%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	534..555	CDD:275368	5/20 (25%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:290200	14/24 (58%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
ZNF44	NP_001157748.1	KRAB	52..88	CDD:279668
		KRAB	52..>88	CDD:214630
		C2H2 Zn finger	192..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	244..655	CDD:227381	114/434 (26%)
		C2H2 Zn finger	247..267	CDD:275368
		zf-H2C2_2	260..282	CDD:290200
		C2H2 Zn finger	275..295	CDD:275368
		zf-H2C2_2	290..310	CDD:290200	2/6 (33%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		zf-H2C2_2	318..339	CDD:290200	6/22 (27%)
		C2H2 Zn finger	331..351	CDD:275368	8/22 (36%)
		zf-H2C2_2	343..366	CDD:290200	7/26 (27%)
		C2H2 Zn finger	359..379	CDD:275368	4/19 (21%)
		C2H2 Zn finger	387..407	CDD:275368	1/19 (5%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..480	CDD:290200	8/23 (35%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..518	CDD:275368	5/20 (25%)
		C2H2 Zn finger	526..546	CDD:275368	9/20 (45%)
		C2H2 Zn finger	554..574	CDD:275368	9/47 (19%)
		zf-H2C2_2	566..589	CDD:290200	11/88 (13%)
		C2H2 Zn finger	582..602	CDD:275368	5/20 (25%)
		zf-H2C2_2	595..619	CDD:290200	7/24 (29%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		zf-H2C2_2	624..647	CDD:290200	14/22 (64%)
		C2H2 Zn finger	638..658	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5652
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950