DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and CG31365

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	138/729 - (18%)
Similarity:	231/729 - (31%)	Gaps:	256/729 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLCLTCLVHLKHGAGHDLFVVPD----LFQKLRACTSFDADQNDGFPRNLCTQCFTKLNDLHDFR 69
            :||..||  .:|...:.:|...|    :..:|.||.:.||...|..|:.:|.:|..:|.....||
  Fly    12 TLCRLCL--KEHQDAYAIFDEDDTQLSIPVRLMACVALDAKATDTLPKRICQECRYQLEKSFLFR 74

  Fly    70 ELCAESIKRLKEMMTSQRNMPMG----VFESIADDSEAPERPEEPASFDPLLNNKLEMIDNE--- 127
            :.|..:.|:|::.:   |.:.:|    ||....||.:..|...|.:.....:.:|:..:::|
  Fly    75 QRCQWAEKKLRKHI---RLLGLGKRSRVFSKDPDDYDEDELEFEDSIAFIEVQDKVRKLEDEKWR 136

  Fly   128 EDV--------------------FKLLEKVDKELEEHSRDQSEEHFSSAEHNGLEEEKKESEGFN 172
            ||.                    .||..::.|||.|..|.:..:..:....:.:.::.:.....:
  Fly   137 EDFKEEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQVRDDLRNEVSED 201

  Fly   173 SDDEQ---AMGQRRIANDKRKLFRLMSCSICQQKFKKQ---------SKFEEHMKHHNDLLPFQC 225
            ...||   .:|:..:...::|..|..|....:.:.|.|         ||.:...|....|:....
  Fly   202 IRKEQLAMLLGELEVYLTEKKAGRWESLDGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANL 266

  Fly   226 QEESCRKGFTTAGALRLHVDYAHSKKED------TVPC-----TVEGCQLVFSRLRLLTIHLKKV 279
            :....||               .:|:|:      |.|.     .::|.:|
  Fly   267 KATEARK---------------DAKEEEFILGCNTDPANNSDVNIDGLEL--------------- 301

  Fly   280 HNQARVIAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYINSALKNHLLRHA 344
                      .|:...|.|..|| .:.|......||..         |:.:.||||......:.:
  Fly   302 ----------DEEVPAESGEDFR-EINMVGSDVVHTDN---------GEIYIINSASSEDQNQDS 346

  Fly   345 --------GIKNY------VCQYCGVR----------------KTTRQEWSKH---ILIHTQRN- 375
                    ||.:|      ..|:.|.:                ...:|.:|.|   |::..::|
  Fly   347 TPEFDQDNGITSYNIKEDGEIQFSGEKPEEIEDVVVFNLGEEISQEQQVFSFHENVIIVEKEQND 411

  Fly   376 ------------------------------------QFKCRICDYATHTKRVL----ESHVK-IV 399
                                                .|:|.:|..|..|:::|    .:|:| :.
  Fly   412 RDEQTPLKRKRSSELVFKQESSCPQPKTGRITDTVKSFQCHLCPVAFPTQKLLTRHHNTHIKGLK 476

  Fly   400 HEKIRNFACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHEKSVERAL 464
            ..|.....|..|......|.:.|.|.:.|||.|..:|..|:..|...|.|..|:..|
  Fly   477 SGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECELSFSQREVLKRHMDTH-------- 533

  Fly   465 ETYKQVQVNGDASDTQVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKE 529
                          |.|..||
  Fly   534 --------------TGVKRHQ-------------------------------------------- 540

  Fly   530 GMYLCPSCSQGFKSIGNMKRHYKSVH-EKVKDFECRFCSRRFANSQSVKQHEWIHTGEKPFECKT 593
                ||.||..|....|:::|...|| ...:..:|..|.|.|.:...:.:|...|.|.. |.||.
  Fly   541 ----CPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVSGLSRHLVTHAGVM-FSCKQ 600

  Fly   594 CGNRFRQVAALIRH 607
            ||.:|...:|:.||
  Fly   601 CGRQFNDRSAVQRH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	22/74 (30%)
		C2H2 Zn finger	197..217	CDD:275368	5/28 (18%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	5/19 (26%)
		C2H2 Zn finger	351..371	CDD:275368	6/38 (16%)
		C2H2 Zn finger	379..400	CDD:275368	7/25 (28%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	534..555	CDD:275368	7/20 (35%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		zf-H2C2_2	575..600	CDD:290200	9/24 (38%)
		C2H2 Zn finger	591..611	CDD:275368	8/17 (47%)
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	22/74 (30%)
		vATP-synt_E	109..>244	CDD:304907	21/134 (16%)
		RRF	<161..222	CDD:294170	10/60 (17%)
		zf-C2H2_8	454..530	CDD:292531	21/75 (28%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..522	CDD:290200	9/24 (38%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	12/93 (13%)
		C2H2 Zn finger	541..562	CDD:275368	7/20 (35%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	598..617	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930