DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and D19A

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	819	Identity:	356/819 - (43%)
Similarity:	475/819 - (57%)	Gaps:	162/819 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KYSVQSLCLTCLVHLKHGAGHDLFVVPDLFQKLRACTSFDADQNDGFPRNLCTQCFTKLNDLHDF 68
            :||:.|||..||.||::.|.:||::||.|.:||..|||...:||||||:||||.|:||||:||||
  Fly     6 QYSIHSLCRICLNHLQNDAAYDLYLVPGLSKKLCFCTSLSVEQNDGFPKNLCTLCYTKLNELHDF 70

  Fly    69 RELCAESIKRLKEMMTSQ---RNMPMGVFESIADDSEAPERPEEPASFDPLLNNKLEMIDNEEDV 130
            ::.|.:|:::.::::.|.   ......||:......:.|...|:..::|||||:|:|:|:|||||
  Fly    71 QKQCVDSVQKFQDLVASNVFACQSSFDVFDPNVAVQDYPAEEEDHVNYDPLLNHKMELIENEEDV 135

  Fly   131 FKLLEKVDKELEEHSR-------------------DQSEEHFSSAEHN----------------- 159
            ||:||.||||.||..:                   |.|.|..:..:|:
  Fly   136 FKMLEHVDKEAEEVEKEAKVEEDDGGNVSVKMFDDDSSIESGNDNDHDLDFEPNSSDDDIPLAQR 200

  Fly   160 -----------------------------------GLEEEK---KESEGFNSDDEQAMG----QR 182
                                               ..|||:   ..||..:|:|..:.|    ::
  Fly   201 MRGPATGSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSSSESDDSEDGTSRGDKPKRK 265

  Fly   183 RIANDKRKLFRLMSCSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYA 247
            ||..::|.|.|::.|.||.|||||..::|||||:|||||||||:.|:|:||||||..||:|:|:|
  Fly   266 RIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHA 330

  Fly   248 HSKKEDTVPCTVEGCQLVFSRLRLLTIHLKKVHNQARVIAPRGEQSCKECGVVFRCPVAMKKHMY 312
            |::..:...|..|||...|.|:||||.|:||||...:..||..:..|.||..|||||.|:|||||
  Fly   331 HTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRCPTALKKHMY 395

  Fly   313 THTGEELPYPCTICGKGFYINSALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQF 377
            .||||||||||.||||.|.|||||::||:|||||||:||.||||.|||||||:.|||.||:..:|
  Fly   396 KHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHILTHTKEKKF 460

  Fly   378 KCRICDYATHTKRVLESHVKIVHEKIRNFACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKK 442
            |||.||:|:|.|:.|.:|||:||||.::||||||||||||::|||:||.:|||||.||||:|.|.
  Fly   461 KCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSHACKVHERSHTGEKCCECKICGKI 525

  Fly   443 FLHSESLNNHLKIHEK---------------------SVERALETYKQVQVNG--DASDTQVDSH 484
            ||..:||..|||.|||                     ||....:...|:|.:|  .....|:.|.
  Fly   526 FLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQMSVPMPGQMPMQMQTDGLVPMDPNQMPSE 590

  Fly   485 QLLKVYAESVASI---PKNPRRVEQVDVALLAGTAVNP---------TDEIQFVQKEGMYLCPSC 537
            .:||......|::   |||.|||::||::.||||||||         :.::.|.:|||.::||.|
  Fly   591 DMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGQHICPGC 655

  Fly   538 SQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQVA 602
            .:||.:|||||.|||.:|||||||.||||.:||:.:|.::.||||||||||||||.||..|||..
  Fly   656 GRGFNNIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQET 720

  Fly   603 ALIRHQKVHDEKP----------------------AKPLG-----------------------ER 622
            ||.:|.|.| |||                      |:|..                       |.
  Fly   721 ALKKHIKTH-EKPNRRHVPERSAPTQITFRKLEPDAEPRNFDQYQDPAVERAAATAELLAHQLEE 784

  Fly   623 NDRKQKVEALRQEIAKVAKKELKDLKNQLALEKQQDTYE 661
            |:.|:|.|..||:||..|.::|..|:.|..:.|...:|:
  Fly   785 NEAKRKAEIERQKIAAAACEQLTKLQQQQEIIKATTSYD 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	38/70 (54%)
		C2H2 Zn finger	197..217	CDD:275368	13/19 (68%)
		C2H2 Zn finger	294..314	CDD:275368	14/19 (74%)
		C2H2 Zn finger	323..343	CDD:275368	13/19 (68%)
		C2H2 Zn finger	351..371	CDD:275368	15/19 (79%)
		C2H2 Zn finger	379..400	CDD:275368	11/20 (55%)
		C2H2 Zn finger	408..428	CDD:275368	15/19 (79%)
		C2H2 Zn finger	436..456	CDD:275368	11/19 (58%)
		C2H2 Zn finger	534..555	CDD:275368	13/20 (65%)
		C2H2 Zn finger	563..583	CDD:275368	10/19 (53%)
		zf-H2C2_2	575..600	CDD:290200	17/24 (71%)
		C2H2 Zn finger	591..611	CDD:275368	11/19 (58%)
D19A	NP_477304.1	zf-AD	12..83	CDD:214871	38/70 (54%)
		C2H2 Zn finger	343..362	CDD:275368	11/18 (61%)
		C2H2 Zn finger	377..397	CDD:275368	14/19 (74%)
		zf-H2C2_2	389..414	CDD:290200	20/24 (83%)
		C2H2 Zn finger	406..426	CDD:275368	13/19 (68%)
		C2H2 Zn finger	434..454	CDD:275368	15/19 (79%)
		C2H2 Zn finger	462..483	CDD:275368	11/20 (55%)
		C2H2 Zn finger	491..511	CDD:275368	15/19 (79%)
		C2H2 Zn finger	519..539	CDD:275368	11/19 (58%)
		C2H2 Zn finger	652..673	CDD:275368	13/20 (65%)
		C2H2 Zn finger	681..701	CDD:275368	10/19 (53%)
		zf-H2C2_2	694..718	CDD:290200	17/23 (74%)
		C2H2 Zn finger	709..729	CDD:275368	11/19 (58%)
		tolA_full	724..>814	CDD:274303	21/90 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H77239
Inparanoid	1	1.050	123	1.000	Inparanoid score	I3296
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010000
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990