DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and pita

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	649	Identity:	143/649 - (22%)
Similarity:	243/649 - (37%)	Gaps:	147/649 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELKYSVQSLCLTCLVHLKHGAGHDLF-------VVPDLFQKLRACTSFDADQNDGFPRNLCTQCF 59
            |...:.:.:|..||...|..:   :|       ...:|..::.|.|:.:....||.|.::|.:|.
  Fly     9 EAMLTEKRVCRFCLTEQKLAS---IFEENPRVKTTANLPLQIMAITAIEVYAGDGMPGHICLECR 70

  Fly    60 TKLNDLHDFRELC--AESIKRLKEMM------TSQRNMPMGVFES---------IADDSEAPER- 106
            ......:.|:::|  ||::.|...:.      ..:...||.:..|         .|:.||.|::
  Fly    71 LLFEHCYRFKQMCKRAETLLRQYPLTGNWPSPLEKPRAPMTMVASKKLLVVPAKTAEPSETPKKL 135

  Fly   107 -------------------------PEEPASFDPLLNN----KLEMIDNEE----DVFKLLEKVD 138
                                     |...|...|:...    :|::.:|:|    ||..:||.:.
  Fly   136 LNTMAKSSSQVIIEDVQVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQELSMDDVQSMLEDMA 200

  Fly   139 KELEEHSRDQSEEHFSSAEHNGLEEEKKESEGFNSDDEQAMGQRRIANDKRKLFRLMSCSICQQK 203
            .|||:...|..:: .|..:...|   .|.|....:....|..:.|:|..|.|.....:.:|..:.
  Fly   201 SELEKEFPDIPQK-ASPVKPKVL---NKSSIRILNKGPAAPVEPRLATPKVKRDDSGNVAIVTEV 261

  Fly   204 FKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSR 268
            ....             ||...|::..:.              |.....|..||  ..|:..|..
  Fly   262 LDSD-------------LPLDDQDDPTKN--------------AEKVATDVFPC--PDCERSFPL 297

  Fly   269 LRLLTIHLKKVHNQARVIAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYIN 333
            .:||.|| :..|.::|..      .|..|...|.....:.||.:.||||. |:.|.||.|.|...
  Fly   298 QQLLEIH-RLNHTRSRSF------QCLLCEKSFFSKYDLAKHNFVHTGER-PFKCAICSKAFTRK 354

  Fly   334 SALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKI 398
            :.|..|...|..:..::|.||.....:|||..||...|.::..|:|.:|..:...|:.||.| :.
  Fly   355 ALLHRHERTHTDVPKFICVYCEKPFLSRQEMEKHAERHQKKRPFQCGVCTKSFAFKQGLERH-ET 418

  Fly   399 VHEKIRNFACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHEKSVERA 463
            ||.....|.||:|.::|..|.....|.:||.|::...||.|.|.::.|..|:.||:.|.::.:.:
  Fly   419 VHSTNLPFPCQHCERSFSTASKLARHLVAHAGKRAYPCKYCHKSYMLSHHLSRHLRTHTQTSDAS 483

  Fly   464 LETYKQVQVNGDASDTQVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQK 528
            .       |..:...:..:.:.||                    |.||:..||
  Fly   484 F-------VCSECKVSYSNYNDLL--------------------DHALIHATA------------ 509

  Fly   529 EGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQH-EWIHTGE-KPFE 590
              ...||.|.:..:.|.:::.|... |::.:...|.||...|...:.:::| |..|..| :|::
  Fly   510 --SLKCPMCRKQIEDIDSVESHMDQ-HKQSERHACEFCDHIFLTQKCLQRHIEDDHVVEMEPYQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	18/79 (23%)
		C2H2 Zn finger	197..217	CDD:275368	1/19 (5%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..400	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..555	CDD:275368	5/20 (25%)
		C2H2 Zn finger	563..583	CDD:275368	6/20 (30%)
		zf-H2C2_2	575..600	CDD:290200	5/18 (28%)
		C2H2 Zn finger	591..611	CDD:275368	143/649 (22%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871	17/77 (22%)
		COG5048	<281..506	CDD:227381	72/262 (27%)
		C2H2 Zn finger	288..308	CDD:275368	7/22 (32%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..353	CDD:290200	12/25 (48%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..388	CDD:275370	6/15 (40%)
		C2H2 Zn finger	400..420	CDD:275368	6/20 (30%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..506	CDD:275368	5/39 (13%)
		HARE-HTH	<566..625	CDD:294801	1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930