DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and Oaz

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	137/784 - (17%)
Similarity:	212/784 - (27%)	Gaps:	354/784 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 RRIANDKRKLF---RLMSCSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLH 243
            :|..:..:||.   |...|..|:..|.:....:.|||.|:...||||  ..|.:|:.||.||..|
  Fly   332 KRSRDRHKKLHTNERNYKCPHCEAAFSRSDHLKIHMKTHDIQKPFQC--SMCNRGYNTAAALTSH 394

  Fly   244 VD------------------------------------------YAHSKKEDTVPCTVE------ 260
            :.                                          ||.:...|:.|..::
  Fly   395 MQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSR 459

  Fly   261 --------------------GCQLV--FSRLRLLTIHLKKVHNQARVIAPR-----GE---QSCK 295
                                .|..|  ||.|..|..||:.||.|.:..|.:     ||   .||:
  Fly   460 SNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCE 524

  Fly   296 ECGVVFRCPVAMKKHM--------------YTH-------------------------------- 314
            .|.:.|.....:.:||              |.|
  Fly   525 YCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERES 589

  Fly   315 --TGEELP------------------------------YPCTICGKGFYINSALKNHLLRH-AGI 346
              ..::||                              :.|..|..|.....:.:|||..| |..
  Fly   590 RPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEG 654

  Fly   347 KNYVCQYCGVRKTTRQEWSKHILIH--TQRNQF-----------------------------KCR 380
            ...||.:||:....:.|:.:|::.|  ...::|                             ||.
  Fly   655 MQLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCS 719

  Fly   381 ICDYATHTKRVLESHVKI-------------------------VHEKIRN--------------- 405
            :|.....::..::.|:..                         ||.|.|:
  Fly   720 LCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAP 784

  Fly   406 ---FACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESL------------------ 449
               ..|.:|............|..||..:.||..  |.:.| |.|.|
  Fly   785 TNPLQCMFCRAVCSSELEMHFHLAAHARQFRCPS--CPETF-HVEFLLDRHMQSQHGGVKDKEAN 846

  Fly   450 --------------------------NNHLKIHEKSV--------------------------ER 462
                                      ||:..|.:.:|                          ..
  Fly   847 SPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGASGGAGSGGGGAQSGGAPPS 911

  Fly   463 ALETYKQVQVNGDASDTQVDSH----------QLLKVYA---------ESV---------ASIPK 499
            |.:.|..:||:.:|...|...|          .|:::||         |.|         |:.|.
  Fly   912 ANKFYSPLQVDTNALKAQTSPHPALMYGLSQRYLMEMYAAKSTSPSGNEGVGNSQPPAPQATAPP 976

  Fly   500 NPRRV----------EQVDVALLAGTAVNPTDEIQFVQKEGMYL-CPSCSQGFKSIGNMKRHYKS 553
            .|...          |:.|  |.:...::...::....|.|:.| |..|:..|||...:::|.||
  Fly   977 PPPNASTATFSCGMCERQD--LRSEAELHSHRKLAHNLKTGVSLRCAYCAGNFKSRAELEQHMKS 1039

  Fly   554 VHEKVKDFECRFCSRRFANSQSVKQHEWIHT--GEKPFECKTCGNRFRQVAALIRHQKVHDEKPA 616
            .|......:|..|...|.:...:.:|:..|:  |:.. :|..||.....|||...|...|....|
  Fly  1040 CHNSTGKHKCLICDEVFPSPAILAEHKLQHSKVGQSG-KCSHCGQPLEDVAAFRAHLSEHGSDGA 1103

  Fly   617 K-PL 619
            . ||
  Fly  1104 SLPL 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	6/33 (18%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	379..400	CDD:275368	3/45 (7%)
		C2H2 Zn finger	408..428	CDD:275368	3/19 (16%)
		C2H2 Zn finger	436..456	CDD:275368	7/63 (11%)
		C2H2 Zn finger	534..555	CDD:275368	8/20 (40%)
		C2H2 Zn finger	563..583	CDD:275368	4/19 (21%)
		zf-H2C2_2	575..600	CDD:290200	6/26 (23%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368	2/9 (22%)
		zf-H2C2_2	334..359	CDD:290200	6/24 (25%)
		COG5048	336..769	CDD:227381	72/434 (17%)
		zf-C2H2	348..370	CDD:278523	6/21 (29%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	8/21 (38%)
		C2H2 Zn finger	630..650	CDD:275368	6/19 (32%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)
		C2H2 Zn finger	689..707	CDD:275368	0/17 (0%)
		C2H2 Zn finger	1020..1041	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1049..1069	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930