DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and cg

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	168/722 - (23%)
Similarity:	248/722 - (34%)	Gaps:	181/722 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FTKLNDLHDFRELCAESIKRLKEMMTSQRNMPMGVFESIADDSEAPERPEEPASF------DPLL 117
            |:.:..||..:|.|.|.:  :|..:.:..:....:  :.||.|........| ||      ..||
  Fly   168 FSSIGALHLTQEECNEIL--IKRAIAAGHHQTHTI--TAADGSHHHASGGTP-SFCSVGGATTLL 227

  Fly   118 NNKLEMIDNEEDVFKLLEKVDKELEEHSRDQSEEHFSSAEHNGLE----EEKKESEGFNSDDEQA 178
            .:.|..|..:      ::||.:.||::...|.|......|...||    .|.:||..|:..|...
  Fly   228 GDILPGISVQ------VQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATI 286

  Fly   179 MGQRRIANDK-RKLFRLMS----------------CSICQQKFKKQSKFEEHMKHHNDLLPFQCQ 226
            ..:|..:.|: .|.|.|..                |:.|.:.|..:.....|:..|:...|:|||
  Fly   287 KKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQ 351

  Fly   227 EESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSRLRLLTIHLKKVHNQARVIAPRGE 291
            |  |:|.||....|..| ...||::.   |...:.|...|...|.|..| .|.|        .||
  Fly   352 E--CKKSFTLKHHLLTH-SRVHSRER---PFVCQECGRAFPLKRHLVTH-SKFH--------AGE 401

  Fly   292 QS--CKECGVVFRCPVAMKKHMYTHT---GEELPYPCTICGKGFYINSALKNHLLRHAGIKNYVC 351
            :.  |:|||..|    |.:.|:..|:   |...|:.|..||..|.....|.||...|..|. :.|
  Fly   402 RPYVCEECGESF----AQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIP-HSC 461

  Fly   352 QYCGVRKTTRQEWSKHI-LIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIR----------- 404
            ..||.....::....|: .:||......|..|.....||..|..||:..|..:.
  Fly   462 TVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIAN 526

  Fly   405 ---------------------------------------------NFACQYCGKTFGKAYACKIH 424
                                                         .|.|:.||..|....|..:|
  Fly   527 QQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALH 591

  Fly   425 EMAHTGEKRCECKVC------DKKFLHSESLNNHLKIHEKSVERALETYKQVQVNGDASDTQVDS 483
            ...|||:|.....:|      ...||.:.|||....:   :....|.....|.|...:|..||.|
  Fly   592 LRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVV---TANPNLVGQSPVPVQIISSTGQVMS 653

  Fly   484 HQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPSCSQGFKSIGNMK 548
            ...|...|.|.     :|:.|.         ||| ||..:...|:...::.....|..:.....:
  Fly   654 QTTLVQAANST-----HPQAVV---------TAV-PTMPVHGQQQHLQHVAQQQQQQQQQQQQQQ 703

  Fly   549 RHYKSV--HEKVKDFECRFCSRRFANSQSVKQHEWIHTG----EKPFECKTCGNRFRQVAALIRH 607
            :|..||  ..|.|...|..|.:.||....:.||...|..    .:...|: ||..|.|...|:.|
  Fly   704 QHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCE-CGKAFFQKNHLMLH 767

  Fly   608 QKVH-DEKPAKPLGERNDRKQKVEALRQEIA--------------------KVAKKELKDLKNQL 651
            |:.| :.|||       ..:|:..|.:|::|                    ||.|.|:  .:|.:
  Fly   768 QRQHLETKPA-------ISQQQEAATQQQLATAGEQQQVQVQIMPDGQIHGKVIKYEI--CRNVM 823

  Fly   652 ALEKQQD 658
            ..::||:
  Fly   824 PEDQQQE 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	6/21 (29%)
		C2H2 Zn finger	197..217	CDD:275368	4/19 (21%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	4/20 (20%)
		C2H2 Zn finger	379..400	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		C2H2 Zn finger	436..456	CDD:275368	6/25 (24%)
		C2H2 Zn finger	534..555	CDD:275368	4/22 (18%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:290200	7/28 (25%)
		C2H2 Zn finger	591..611	CDD:275368	8/19 (42%)
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	21/86 (24%)
		C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		zf-H2C2_2	306..331	CDD:290200	3/24 (13%)
		C2H2 Zn finger	322..342	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..370	CDD:275368	9/22 (41%)
		zf-H2C2_2	362..385	CDD:290200	6/26 (23%)
		C2H2 Zn finger	378..398	CDD:275368	6/20 (30%)
		zf-H2C2_2	390..415	CDD:290200	11/37 (30%)
		C2H2 Zn finger	406..426	CDD:275368	8/23 (35%)
		SIR2	<425..>465	CDD:294129	12/40 (30%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	4/20 (20%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	18/111 (16%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..771	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100