DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and crol

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	129/514 - (25%)
Similarity:	191/514 - (37%)	Gaps:	99/514 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 NSDDEQAMGQRRIANDKRKLFRLMSCSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTT 236
            |:..|:.|  :|.:.||.     .:|:|||:.|.::...:.|.:.|....||:||  .|.|.||.
  Fly   289 NTSLERHM--KRHSTDKP-----FACTICQKTFARKEHLDNHFRSHTGETPFRCQ--YCAKTFTR 344

  Fly   237 AGALRLHV-----DYAH---------SKKEDTV----------PCTVEGCQLVFSRLRLLTIHLK 277
            ...:..||     :..|         ::||..|          |...:.|...::|...|..|::
  Fly   345 KEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMR 409

  Fly   278 KVHNQARVIAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYINSALKNHLLR 342
            ...|:...       .|:.||..|........|:..||| |.|:.|..|.|.|.....|.||:.:
  Fly   410 SHTNETPF-------RCEICGKSFSRKEHFTNHILWHTG-ETPHRCDFCSKTFTRKEHLLNHVRQ 466

  Fly   343 HAGIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIRNFA 407
            |.|...:.|.||....|.::....||..||....|||..|..|...|..:.:||: .|.......
  Fly   467 HTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR-QHTGESPHK 530

  Fly   408 CQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHEKSVERALETYKQVQV 472
            |.||.|||.:......|...|||:....|..|.|.|...|.|.||:::|........|..::...
  Fly   531 CTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFT 595

  Fly   473 NGDASDTQVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGM------ 531
            ..:..:..:..|.....:..:|.:.|                          |.:||.:
  Fly   596 RKEHLNNHMRQHSSDNPHCCNVCNKP--------------------------FTRKEHLINHMSR 634

  Fly   532 -------YLCPSCSQGFKSIGNMKRHYKSVHEKVKD----FECRFCSRRFANSQSVKQHEWIHTG 585
                   :.|.:|.:.|...||:..|.:| |.|.::    |.|..|.:.|.....:..|...|:|
  Fly   635 CHTGDRPFTCETCGKSFPLKGNLLFHQRS-HTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSG 698

  Fly   586 EKPFECKTCGNRFRQVAALIRHQK------------VHDEKPAKPLGERNDRKQKVEAL 632
            |||..|..|...|.:...|.||.|            ||.. |..|.|.....||:|:.:
  Fly   699 EKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPH-PQIPAGVLTQVKQEVKPI 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..400	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..555	CDD:275368	7/20 (35%)
		C2H2 Zn finger	563..583	CDD:275368	4/19 (21%)
		zf-H2C2_2	575..600	CDD:290200	9/24 (38%)
		C2H2 Zn finger	591..611	CDD:275368	7/31 (23%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	3/11 (27%)
		COG5048	300..723	CDD:227381	116/465 (25%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/21 (38%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	6/20 (30%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	1/19 (5%)
		C2H2 Zn finger	615..636	CDD:275368	5/46 (11%)
		C2H2 Zn finger	644..664	CDD:275368	7/20 (35%)
		C2H2 Zn finger	676..696	CDD:275368	4/19 (21%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446653
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840