DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7386 and CG2116

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_572444.2	Gene:	CG2116 / 31735	FlyBaseID:	FBgn0030003	Length:	598	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	122/602 - (20%)
Similarity:	212/602 - (35%)	Gaps:	199/602 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FVVPDLFQKLRACTSFDADQNDGFPRNLCTQ---CFTKLNDL-HDFRE--LCAESIKRLKEMMTS 85
            ||:|       |.:.:..:.|.|..|.:.|.   .:..|::| ::|.|  :........|||:.|
  Fly    14 FVLP-------ANSDYSDEDNRGNVRVINTSDDATYVLLDNLGNEFEEDIIIVNENGVEKEMLMS 71

  Fly    86 Q--RNMPMGV-FESIADDSEAPERPEEPASFDPLLNNKLEMIDNEEDVFKLLEKVDKELEEHSRD 147
            :  |:..:|. .:.:.||.:.|:          .:..:|:|    .:|..|:| |:.|:|:.: |
  Fly    72 KELRDFIVGSRVKDLTDDEQMPQ----------FVVRELDM----SEVGDLVE-VEPEMEQEA-D 120

  Fly   148 QSEEHFSSAEHNGLEEEKKESEGFNSDDE---------------------QAMGQRRIANDKRKL 191
            ..:  :...||.......:::|....|.:                     |...:.|  |..|:
  Fly   121 YGD--YGDYEHEPSYGHPRDNERVEEDLDMYPPSSPSLPPSPPRPPSPVVQPASKAR--NSARQ- 180

  Fly   192 FRLMSCSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESC---RKGFTTAGALRLHVDYAHSKKED 253
                   |..:.|..|...::......::.|.:...|..   |:.......:...||:    .||
  Fly   181 -------IALRSFVSQKNNDDDDGSVKEVKPSEKMLEEFKGPRRYMLFDDLIATIVDF----DED 234

  Fly   254 TVPCTVEGCQLVFSRLRLLTIHLKKVHNQARVIAPRGEQSCKECGVVFRCPVAM-----KKHMYT 313
            :.| .||     ||.:..:                ..|:...|||:   ||..|     .||..|
  Fly   235 STP-LVE-----FSMISDI----------------MDEKLPVECGI---CPDVMHKSKLSKHHKT 274

  Fly   314 HTGEELP----YPCTICGKGFYINSALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHILIHTQR 374
            |.   :|    |.|..|.:.:.....|..|..||.||:.|||:.|.:..:|:|:    :.:|.||
  Fly   275 HL---VPGTNRYACIYCTETYRDCKYLAGHARRHMGIRPYVCELCTLYFSTKQD----LRVHNQR 332

  Fly   375 NQFK----CRIC--DYATHTKRVLESHVKIVHEKIRNFACQYCGKTFGKAYACKIH-EMAHTGEK 432
            ...:    |.:|  .:|.:|:  |:.|.:..|||.|.|.|:||.|.:.|.::.:.| ...|.|::
  Fly   333 RHLEKEHICEVCGKTFAQNTQ--LKRHREATHEKKRRFQCEYCQKAYYKNFSLQEHIRNVHMGKR 395

  Fly   433 R-CECKVCDKKFLHSESLNNHLKIHEKSVERALETYKQVQVNGDASDTQVDSHQLLKVYAESVAS 496
            | .:|..|..:...:..:..|.|                           :.|
  Fly   396 RMLKCPFCGMQCRDAHKMARHRK---------------------------EMH------------ 421

  Fly   497 IPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDF 561
                                          ..:|.|:|..|.:.|..|.....|.:|:
  Fly   422 ------------------------------LSQGTYVCHLCQEEFTDISYFDAHKRSI------- 449

  Fly   562 ECRFCSRRFANSQSVKQ 578
            :||..:|||.|:...::
  Fly   450 QCRSNTRRFVNADGNRE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871	12/59 (20%)
		C2H2 Zn finger	197..217	CDD:275368	3/19 (16%)
		C2H2 Zn finger	294..314	CDD:275368	8/24 (33%)
		C2H2 Zn finger	323..343	CDD:275368	4/19 (21%)
		C2H2 Zn finger	351..371	CDD:275368	4/19 (21%)
		C2H2 Zn finger	379..400	CDD:275368	6/22 (27%)
		C2H2 Zn finger	408..428	CDD:275368	6/20 (30%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)
		C2H2 Zn finger	563..583	CDD:275368	6/16 (38%)
		zf-H2C2_2	575..600	CDD:290200	0/4 (0%)
		C2H2 Zn finger	591..611	CDD:275368
CG2116	NP_572444.2	C2H2 Zn finger	256..275	CDD:275368	7/21 (33%)
		C2H2 Zn finger	285..305	CDD:275368	4/19 (21%)
		PHA00733	<308..357	CDD:177301	15/54 (28%)
		C2H2 Zn finger	313..334	CDD:275368	7/24 (29%)
		C2H2 Zn finger	341..362	CDD:275368	6/22 (27%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	400..418	CDD:275370	3/17 (18%)
		C2H2 Zn finger	429..447	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449764
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930