DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7386 and ZNF358

DIOPT Version :9

Sequence 1:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_060553.4	Gene:	ZNF358 / 140467	HGNCID:	16838	Length:	568	Species:	Homo sapiens

Alignment Length:	528	Identity:	126/528 - (23%)
Similarity:	184/528 - (34%)	Gaps:	155/528 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 VFESIADDSE-APERPE--EPASFDPLLNNKLEMIDNEEDVFKLLEKVD---KELEEHSRDQSEE 151
            |:|.:..||| ....||  :|.|.||        ..:.||:..:.|.||   ::||..|.|...:
Human    18 VYEELDSDSEDLDPNPEDLDPVSEDP--------EPDPEDLNTVPEDVDPSYEDLEPVSEDLDPD 74

  Fly   152 HFSSAEHNGLEEEKKE--SEGFNSDDEQAMGQRRIANDKRKLFRLMSCSICQQKFKKQSKFEEHM 214
                ||..|.|.:..:  |..|:.|.: .:|...:..|
Human    75 ----AEAPGSEPQDPDPMSSSFDLDPD-VIGPVPLILD--------------------------- 107

  Fly   215 KHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSRLRLLTIHLKKV 279
            .:.:.|.|...:.:....|.|           |..:...|.|..:
Human   108 PNSDTLSPGDPKVDPISSGLT-----------ATPQVLATSPAVL-------------------- 141

  Fly   280 HNQARVIAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYPCTICGKGFYINSALKNHLLRHA 344
              .|....|| ..||.:||..||....:.:|..||:||: ||.|..|||.|...:.|..|...|.
Human   142 --PAPASPPR-PFSCPDCGRAFRRSSGLSQHRRTHSGEK-PYRCPDCGKSFSHGATLAQHRGIHT 202

  Fly   345 GIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIRNFACQ 409
            |.:.|.|..||.....|....||...|:......|.:|..|.....:|..|:: .|...|...|.
Human   203 GARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLR-THGGPRPHKCP 266

  Fly   410 YCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHEKSVERALETYKQVQVNG 474
            .|.|.||:..|...|...||||:...|..|.|.|..|.:|..|.:.|
Human   267 VCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTH------------------ 313

  Fly   475 DASDTQVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGTAVNPTDEIQFVQKEGMYLCPSCSQ 539
                                                    ||..|            |.||.|.:
Human   314 ----------------------------------------TAERP------------YRCPHCGK 326

  Fly   540 GFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHEWIHTGEKPFECKTCGNRFRQVAAL 604
            .|....|::.|.: :|...:.:.|..||:.|..|.::.||..:|:||:|:.|:.||..|.|.::|
Human   327 AFGQSSNLQHHLR-IHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSL 390

  Fly   605 IRHQKVHD 612
            .:|::||:
Human   391 TKHKRVHE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	0/19 (0%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..400	CDD:275368	5/20 (25%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
		zf-H2C2_2	575..600	CDD:290200	10/24 (42%)
		C2H2 Zn finger	591..611	CDD:275368	7/19 (37%)
ZNF358	NP_060553.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117		31/138 (22%)
		COG5048	<35..339	CDD:227381	98/449 (22%)
		lambda-1	108..>174	CDD:212564	18/99 (18%)
		zf-C2H2	151..173	CDD:278523	7/21 (33%)
		C2H2 Zn finger	153..173	CDD:275368	6/19 (32%)
		zf-H2C2_2	166..190	CDD:290200	12/24 (50%)
		C2H2 Zn finger	181..201	CDD:275368	7/19 (37%)
		zf-H2C2_2	194..216	CDD:290200	8/21 (38%)
		C2H2 Zn finger	209..229	CDD:275368	6/19 (32%)
		zf-H2C2_2	222..244	CDD:290200	5/21 (24%)
		C2H2 Zn finger	237..257	CDD:275368	5/20 (25%)
		zf-H2C2_2	250..272	CDD:290200	7/22 (32%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		zf-H2C2_2	277..300	CDD:290200	9/22 (41%)
		zf-C2H2_8	292..370	CDD:292531	26/148 (18%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		zf-H2C2_2	305..328	CDD:290200	10/92 (11%)
		C2H2 Zn finger	321..341	CDD:275368	6/20 (30%)
		zf-H2C2_2	333..356	CDD:290200	6/23 (26%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		zf-H2C2_2	361..384	CDD:290200	9/22 (41%)
		zf-C2H2	375..397	CDD:278523	7/21 (33%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910