Protein Alignment CG7386 and ZNF573

DIOPT Version :10

• Sequence 1: NP_648036.1
• Gene: CG7386 / 38719
• FlyBaseID: FBgn0035691
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_001166161.1
• Gene: ZNF573 / 126231
• HGNCID: 26420
• Length: 665
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 132/421 - (31%)
• Similarity: 193/421 - (45%)
• Gaps: 70/421 - (16%)

  Fly   197 CSICQQKFKKQSKFEEHMKHHNDLLPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEG 261
            |..|.:.|::..:...|.:.|....|::|:|  |.||:|||....||.......|    |...:.
Human   304 CEKCGKAFRRGHQLTVHQRVHTGKKPYECKE--CGKGYTTASYFLLHQRIHKGGK----PYECKE 362

  Fly   262 CQLVFSRLRLLTIHLKKVHNQARVIAPRGEQ--SCKECGVVFRCPVAMKKHMYTHTGEELPYPCT 324
            |:..|:..|.||.| :.:|.        ||:  .||:||..:.....:.:|..|||||: ||.|.
Human   363 CKKTFTLYRNLTRH-QNIHT--------GEKLFECKQCGKTYTTGSKLFQHQKTHTGEK-PYECK 417

  Fly   325 ICGKGFYINSALKNHLLRHAGIKNYVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTK 389
            .|||.|.:...||.|...|.|:|::.|:.|....|..:..::|..|||.:..|:|:.|..|..|.
Human   418 ECGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYRNLTRHQNIHTGKKLFECQECGKAYSTG 482

  Fly   390 RVLESHVKIVHEKIRNFACQYCGKTFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLK 454
            ..|..|.| .|...:.:.|:.|||||........|:..|||.|..|||||.|.|....:|..|..
Human   483 SNLIQHRK-THTGEKPYKCKECGKTFSLHGYLNQHQKIHTGMKPYECKVCRKTFTFYRNLTLHQS 546

  Fly   455 IH--EKSVE--RALETYKQVQVNGDASDTQVDSHQLLKVYAESVASIPKNPRRVEQVDVALLAGT 515
            ||  ||..|  ...:|:::        .:.:.:||  .::|:      |.|
Human   547 IHTDEKPFECKECGKTFRR--------SSHLTAHQ--SIHAD------KKP-------------- 581

  Fly   516 AVNPTDEIQFVQKEGMYLCPSCSQGFKSIGNMKRHYKSVHEKVKDFECRFCSRRFANSQSVKQHE 580
                            |.|..|.:.||..|.:.:|.| :|...|.:||:.|.:.|:.:.::.|||
Human   582 ----------------YECKECGKAFKMYGYLTQHQK-IHTGGKPYECKECGKAFSRASNLVQHE 629

  Fly   581 WIHTGEKPFECKTCGNRFRQVAALIRHQKVH 611
            .|||||||:.||.||..||..:||..||::|
Human   630 RIHTGEKPYVCKQCGKTFRYGSALKAHQRIH 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	4/19 (21%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..371	CDD:275368	4/19 (21%)
		C2H2 Zn finger	379..400	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..555	CDD:275368	7/20 (35%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:463886	15/24 (63%)
		C2H2 Zn finger	591..611	CDD:275368	10/19 (53%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630
		C2H2 Zn finger	136..156	CDD:275368
		COG5048	160..521	CDD:227381	73/233 (31%)
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	192..212	CDD:275368
		C2H2 Zn finger	220..240	CDD:275368
		C2H2 Zn finger	248..268	CDD:275368
		C2H2 Zn finger	276..292	CDD:275368
		C2H2 Zn finger	304..324	CDD:275368	4/19 (21%)
		C2H2 Zn finger	332..352	CDD:275368	10/21 (48%)
		C2H2 Zn finger	360..380	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		COG5048	442..>664	CDD:227381	82/267 (31%)
		C2H2 Zn finger	444..464	CDD:275368	4/19 (21%)
		C2H2 Zn finger	472..492	CDD:275368	7/20 (35%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		C2H2 Zn finger	528..548	CDD:275368	8/19 (42%)
		C2H2 Zn finger	556..576	CDD:275368	3/29 (10%)
		C2H2 Zn finger	584..604	CDD:275368	7/20 (35%)
		C2H2 Zn finger	612..632	CDD:275368	6/19 (32%)
		C2H2 Zn finger	640..660	CDD:275368	10/19 (53%)