DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and ZNF43

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens

Alignment Length:	510	Identity:	143/510 - (28%)
Similarity:	198/510 - (38%)	Gaps:	132/510 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 HRII-------DCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHAHT 332
            |:||       .|..|.:.|.::....||.|.|....|::|  |.|.|.|...:.|..| ...||
Human   285 HKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKH-KRIHT 346

  Fly   333 ELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRCPTALKKHMYKH 397
            . .:.:.|  |.|||.|.:...||.| |::|...|.      :.||||...|...:.|.||...|
Human   347 G-EKPYTC--EECGKAFNQFSNLTTH-KRIHTAEKF------YKCTECGEAFSRSSNLTKHKKIH 401

  Fly   398 TGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCG------------------------ 438
            | |:.||.|..|||.|..:|.|.:|.:.|.|.|.:.|..||
Human   402 T-EKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKCEECGKAFNWPSTLTKHNRIHTGEKPYKC 465

  Fly   439 --VGKTTRQEWN--AHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFG 499
              .||...|..|  .|...||.||.:||.:|..|......|:.| |.:|.::|.:.|:.|||.|.
Human   466 EVCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKH-KKIHIEKKPYKCEECGKAFK 529

  Fly   500 KSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQMSV 564
            .|.....|:.:|||||..:|:.|||.|.....||||.:.|
Human   530 WSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIH------------------------- 569

  Fly   565 PMPGQMPMQMQTDGLVPMDPNQMPSEDML---------KACGGGTAAVPPKPKNSRRVQRVDISQ 620
              .|:.|.:.:..|......:.:.:...:         :.||
Human   570 --TGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECG----------------------- 609

  Fly   621 LAGTAVNPIPSVSVPSWSPQVNFTKKEGQHI------CPGCGRGFNNIGNMKLHYKIIHEKVKDF 679
                          .:::...|.|..:..|.      |..||:.||....:..| ||||.:.|.:
Human   610 --------------KAFTQSSNLTTHKKIHTGGKPYKCEECGKAFNQFSTLTKH-KIIHTEEKPY 659

  Fly   680 ACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKH--IKTHEKP 732
            .|..|.|.|..:..|..|:.|||||||::|:.|||.|:..:.|..|  |.|.|||
Human   660 KCEECGKAFKWSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLSTHKIIHTGEKP 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	9/18 (50%)
		C2H2 Zn finger	377..397	CDD:275368	8/19 (42%)
		zf-H2C2_2	389..414	CDD:290200	12/24 (50%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		C2H2 Zn finger	434..454	CDD:275368	8/47 (17%)
		C2H2 Zn finger	462..483	CDD:275368	6/20 (30%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	9/19 (47%)
		C2H2 Zn finger	652..673	CDD:275368	8/20 (40%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		zf-H2C2_2	694..718	CDD:290200	14/23 (61%)
		C2H2 Zn finger	709..729	CDD:275368	8/21 (38%)
		tolA_full	724..>814	CDD:274303	6/11 (55%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368	2/3 (67%)
		COG5048	295..763	CDD:227381	140/500 (28%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..333	CDD:290200	9/25 (36%)
		C2H2 Zn finger	325..345	CDD:275368	7/22 (32%)
		zf-H2C2_2	338..362	CDD:290200	10/27 (37%)
		C2H2 Zn finger	353..373	CDD:275368	10/22 (45%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		zf-H2C2_2	393..417	CDD:290200	12/24 (50%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	422..445	CDD:290200	8/22 (36%)
		C2H2 Zn finger	437..457	CDD:275368	3/19 (16%)
		zf-H2C2_2	450..474	CDD:290200	2/23 (9%)
		C2H2 Zn finger	465..485	CDD:275368	5/19 (26%)
		zf-H2C2_2	477..502	CDD:290200	10/24 (42%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		zf-H2C2_2	534..558	CDD:290200	11/23 (48%)
		C2H2 Zn finger	549..569	CDD:275368	9/19 (47%)
		zf-H2C2_2	562..586	CDD:290200	8/50 (16%)
		C2H2 Zn finger	577..597	CDD:275368	1/19 (5%)
		zf-H2C2_2	589..614	CDD:290200	2/61 (3%)
		C2H2 Zn finger	605..625	CDD:275368	4/56 (7%)
		zf-H2C2_2	617..642	CDD:290200	7/24 (29%)
		C2H2 Zn finger	633..653	CDD:275368	8/20 (40%)
		C2H2 Zn finger	661..681	CDD:275368	6/19 (32%)
		zf-H2C2_2	674..697	CDD:290200	13/22 (59%)
		C2H2 Zn finger	689..709	CDD:275368	7/19 (37%)
		zf-H2C2_2	702..726	CDD:290200	7/13 (54%)
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12366
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950