DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and znf990

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001032484.1	Gene:	znf990 / 641418	ZFINID:	ZDB-GENE-051113-232	Length:	646	Species:	Danio rerio

Alignment Length:	631	Identity:	163/631 - (25%)
Similarity:	239/631 - (37%)	Gaps:	111/631 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 DGGNVSVKMFDDDSSIESGNDNDHDLDFEPNSSDDDIPLAQ--------RMRGPATGSGPQQDRF 215
            |.|..::|..|.:..|:..|:|....|......:..|...:        |...|........:.|
Zfish     3 DSGVCTIKQEDTEEQIDLLNENKEIEDLIKRGENHHIKTEESLYSISMIRKDNPCFTCLQCANTF 67

  Fly   216 S---NLDKPKPRPRGRPKKIKPPPPEEEELSDSSSESDDSEDGTSRGDKPKRKRIPIEERHLHRI 277
            |   ||:....    ..|::||..|             |..|.....:......:..||    .:
Zfish    68 SCEENLNLHMK----IHKEVKPHNP-------------DQCDEIFTVEVTNNINVHAEE----TV 111

  Fly   278 IDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHAHTELSEVHACIA 342
            .:|..|.:.|........|||:|:...||.|  :.|.:.|..||.|:.| ...|:.:.. |.|
Zfish   112 YNCDQCDRTFTDKRNLAAHMKFHSGEKPFMC--DLCGRSFLYANTLKKH-RKLHSAVKN-HVC-- 170

  Fly   343 EGCGKTFPRVRLLTFHMKKVHGITKAA-APL-------------------------RDFPCTECD 381
            ..|||:|     .|:...|:|....|. .|.                         :...|.:|:
Zfish   171 SKCGKSF-----FTYSQLKIHHTAHATEKPFKCSHCGKGFKSLQCQRIHEMIHSGEKPHKCDQCE 230

  Fly   382 TVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQE 446
            ..||...:|..||..||||: ||.|:.||:.|.....|..||..|:|...:.|..||.|.....:
Zfish   231 KTFRQRKSLNIHMRIHTGEK-PYTCDHCGRSFSRKETLNSHLKTHSGNMLYTCAECGEGFNNTGD 294

  Fly   447 WNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSHACKVHERSH 511
            :.||:.||..|..|.|.||.....|:.||..| :.:|:..||..|..|||||..:...|.|||.|
Zfish   295 FTAHMKTHFGENPFLCDQCGKGFPNRTALKKH-QNIHKGLKDHVCSKCGKTFLTNAILKAHERLH 358

  Fly   512 TGEKCCECKICGKIFLCEKSLTKHLKTHEKRDL--------PPAEPLRQQLNIPMPGQMSVPMPG 568
            |.|:..:|..|.|.|    .|::|||.|.|...        |..:..||:.::.:..:....
Zfish   359 TTERPHKCSHCDKAF----KLSQHLKIHVKIHTGEKPYSCDPCGKSFRQKRDLDVHIEKHTE--- 416

  Fly   569 QMPMQMQTDGL-------VPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAV 626
            :.|.:....|.       :....|....|:....| |.:.|.....:|..::.         |..
Zfish   417 EKPHKCDQCGAGFARKLSLANHKNIHTGENTCDQC-GMSFATKSSLENHMKIH---------TGE 471

  Fly   627 NPIPS-------VSVPSWSPQVNFTKKEGQHICPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFC 684
            .|...       ....|.:..:.....|..|.|..||:.|......|.|. :.|.:.:.:.|..|
Zfish   472 KPFTCDHCEASFARRDSLANHIKLHTGENLHKCDQCGKSFRRYDVFKAHL-LTHSRERIYKCNQC 535

  Fly   685 PKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKHIKTHE 730
            .|.|.|..:||.|..:||.|:|:.|.:||:.||.:||||.|.|.|:
Zfish   536 DKSFFKPSLLRDHRKVHTDERPYVCYLCGRSFRYKTALKIHQKRHD 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	5/18 (28%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..414	CDD:290200	12/24 (50%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	462..483	CDD:275368	7/20 (35%)
		C2H2 Zn finger	491..511	CDD:275368	10/19 (53%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		C2H2 Zn finger	652..673	CDD:275368	6/20 (30%)
		C2H2 Zn finger	681..701	CDD:275368	8/19 (42%)
		zf-H2C2_2	694..718	CDD:290200	11/23 (48%)
		C2H2 Zn finger	709..729	CDD:275368	11/19 (58%)
		tolA_full	724..>814	CDD:274303	3/7 (43%)
znf990	NP_001032484.1	C2H2 Zn finger	60..80	CDD:275368	4/23 (17%)
		COG5048	110..494	CDD:227381	107/413 (26%)
		C2H2 Zn finger	114..134	CDD:275368	6/19 (32%)
		C2H2 Zn finger	142..162	CDD:275368	7/22 (32%)
		C2H2 Zn finger	170..190	CDD:275368	8/26 (31%)
		C2H2 Zn finger	198..218	CDD:275368	0/19 (0%)
		C2H2 Zn finger	226..246	CDD:275368	7/19 (37%)
		zf-H2C2_2	238..263	CDD:290200	13/25 (52%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..330	CDD:275368	7/20 (35%)
		C2H2 Zn finger	338..358	CDD:275368	10/19 (53%)
		COG5048	362..>646	CDD:227381	57/238 (24%)
		C2H2 Zn finger	366..386	CDD:275368	10/23 (43%)
		zf-H2C2_2	378..403	CDD:290200	6/24 (25%)
		C2H2 Zn finger	394..414	CDD:275368	3/19 (16%)
		C2H2 Zn finger	422..442	CDD:275368	2/19 (11%)
		C2H2 Zn finger	448..468	CDD:275368	4/20 (20%)
		zf-H2C2_2	460..485	CDD:290200	3/33 (9%)
		C2H2 Zn finger	476..496	CDD:275368	1/19 (5%)
		C2H2 Zn finger	504..524	CDD:275368	6/20 (30%)
		C2H2 Zn finger	532..552	CDD:275368	8/19 (42%)
		C2H2 Zn finger	560..580	CDD:275368	11/19 (58%)
		C2H2 Zn finger	588..608	CDD:275368
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000