DRSC/TRiP Functional Genomics Resources

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Protein Alignment D19A and Plag1

DIOPT Version :9

Sequence 1:NP_477304.1 Gene:D19A / 38718 FlyBaseID:FBgn0022935 Length:845 Species:Drosophila melanogaster
Sequence 2:NP_064353.2 Gene:Plag1 / 56711 MGIID:1891916 Length:499 Species:Mus musculus


Alignment Length:441 Identity:108/441 - (24%)
Similarity:163/441 - (36%) Gaps:84/441 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 SESDDSEDGTS----RGDKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQ 307
            ||..|::...|    ||:...||..|           |.:|.:.|....:.:.|...|....|::
Mouse    10 SEVRDTQKAPSGKRKRGESKPRKNFP-----------CQLCDKAFNSVEKLKVHSFSHTGERPYK 63

  Fly   308 CKVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPL 372
            |..:.|.|.|.:...|:.|:  |.....:.|.|  ..|.|.|.|...|..|: ..|...|     
Mouse    64 CTHQDCTKAFVSKYKLQRHM--ATHSPEKTHKC--NYCEKMFHRKDHLKNHL-HTHDPNK----- 118

  Fly   373 RDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYC 437
            ..|.|.||...:......|:|:..|........|.:|.:.|.....|.:||..|||..:.     
Mouse   119 ETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQNFESTGVLLEHLKSHAGKSSG----- 178

  Fly   438 GVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFG-KS 501
            ||                ||||.:|..|:...:.::.:..|: |||..||||.||||.:.|| |.
Mouse   179 GV----------------KEKKHQCEHCERRFYTRKDVRRHM-VVHTGRKDFLCQYCAQRFGRKD 226

  Fly   502 HACKVHERSHTGEKCCECKICGKI----------FLCEKSLTKHLKTHEKRDLPPAEPLRQ---- 552
            |..:..::||..|..       |:          |.|..|:....:......||.:|.|.:    
Mouse   227 HLTRHMKKSHNQELL-------KVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSELLSKPFTN 284

  Fly   553 --QLNI---PMPGQMSVPMPGQMPMQMQTDGLVPMDPNQM-PSEDMLKACGGGTA----AVPPKP 607
              |||:   |.....|.....||...:......|:|.:.: ||..:...|...:.    ::|.|.
Mouse   285 TLQLNLYNTPFQSMQSSGSAHQMITTLPLGMTCPIDMDAVHPSHHLAFKCPFSSTSYAISIPEKE 349

  Fly   608 KNSRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGQHICPGCGRG 658
            :..:......:.:|.|.|  |..|...|:.|.::....:.|.   |..|.|
Mouse   350 QPLKGEIESYLMELQGGA--PSSSQDSPASSSKLGLEPQSGS---PDDGAG 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
D19ANP_477304.1 zf-AD 12..83 CDD:214871
C2H2 Zn finger 343..362 CDD:275368 6/18 (33%)
C2H2 Zn finger 377..397 CDD:275368 5/19 (26%)
zf-H2C2_2 389..414 CDD:290200 5/24 (21%)
C2H2 Zn finger 406..426 CDD:275368 6/19 (32%)
C2H2 Zn finger 434..454 CDD:275368 2/19 (11%)
C2H2 Zn finger 462..483 CDD:275368 4/20 (20%)
C2H2 Zn finger 491..511 CDD:275368 8/20 (40%)
C2H2 Zn finger 519..539 CDD:275368 4/29 (14%)
C2H2 Zn finger 652..673 CDD:275368 3/7 (43%)
C2H2 Zn finger 681..701 CDD:275368
zf-H2C2_2 694..718 CDD:290200
C2H2 Zn finger 709..729 CDD:275368
tolA_full 724..>814 CDD:274303
Plag1NP_064353.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 7/22 (32%)
Interaction with KPNA2. /evidence=ECO:0000250 2..84 21/86 (24%)
Nuclear localization signal. /evidence=ECO:0000250 22..25 0/2 (0%)
C2H2 Zn finger 36..56 CDD:275368 4/19 (21%)
Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250 41..242 64/239 (27%)
SFP1 <58..139 CDD:227516 23/90 (26%)
C2H2 Zn finger 64..86 CDD:275368 7/23 (30%)
zf-H2C2_2 79..103 CDD:404364 8/27 (30%)
C2H2 Zn finger 94..114 CDD:275368 7/22 (32%)
C2H2 Zn finger 123..143 CDD:275368 5/19 (26%)
C2H2 Zn finger 152..172 CDD:275368 6/19 (32%)
C2H2 Zn finger 187..207 CDD:275368 4/20 (20%)
C2H2 Zn finger 215..233 CDD:275368 8/17 (47%)
Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250 243..499 32/158 (20%)
Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250 243..383 28/141 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 365..400 10/36 (28%)
Massively activates transcription. /evidence=ECO:0000250 384..499 4/15 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24388
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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