DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and Sry-beta

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001303451.1	Gene:	Sry-beta / 43570	FlyBaseID:	FBgn0003511	Length:	356	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	87/399 - (21%)
Similarity:	128/399 - (32%)	Gaps:	133/399 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 NYDPLLNHKMELIENEEDVFKMLEHVDKEAEEVEKEAKVEEDDGGNVSVKMFDDDSSIESGNDND 181
            |||.|:.:..::.....|.......|:.:||..::.||     ...|.|..|
  Fly    68 NYDRLVRNLSQVQRQIADALLGCRQVEGKAETKQQAAK-----RARVQVPAF------------- 114

  Fly   182 HDLDFEPNSSDDDIPLAQRMRGPATGSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSS 246
                        .|..|..::.|....| ::|......|                   ||:.|..
  Fly   115 ------------KIVQATALKEPERQPG-EEDECEEFMK-------------------EEMLDEE 147

  Fly   247 ---SESDDSEDGTSRGDKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQC 308
               ||.|||...:......:...||           ||||.:.|......|.|:
  Fly   148 FQFSEPDDSMPSSEEEFFTETTEIP-----------CHICGEMFSSQEVLERHI----------- 190

  Fly   309 KVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLR 373
            |.:||:|                   ||...|  ..||.......:|..||....|.|
  Fly   191 KADTCQK-------------------SEQATC--NVCGLKVKDDEVLDLHMNLHEGKT------- 227

  Fly   374 DFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNH-VCPYC 437
            :..|..||..|.....:.:||..| .::..|.|:.||:||.::..:.:|||||...:|. :|..|
  Fly   228 ELECRYCDKKFSHKRNVLRHMEVH-WDKKKYQCDKCGERFSLSWLMYNHLMRHDAEENALICEVC 291

  Fly   438 GVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSH 502
            .....|::.:..|:.||         |.|                   |..:.|..|.|:|...:
  Fly   292 HQQFKTKRTYKHHLRTH---------QTD-------------------RPRYPCPDCEKSFVDKY 328

  Fly   503 ACKVHERSH 511
            ..|||:|.|
  Fly   329 TLKVHKRVH 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	5/18 (28%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..414	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	462..483	CDD:275368	2/20 (10%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	652..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		zf-H2C2_2	694..718	CDD:290200
		C2H2 Zn finger	709..729	CDD:275368
		tolA_full	724..>814	CDD:274303
Sry-beta	NP_001303451.1	C2H2 Zn finger	203..223	CDD:275368	6/21 (29%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..308	CDD:275368	15/48 (31%)
		C2H2 Zn finger	288..303	CDD:275370	3/14 (21%)
		zf-C2H2	315..337	CDD:278523	8/21 (38%)
		C2H2 Zn finger	317..337	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930