DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and su(Hw)

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster

Alignment Length:	894	Identity:	186/894 - (20%)
Similarity:	301/894 - (33%)	Gaps:	266/894 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 AEEEDHVNYDPLLNHKME-------------------LIENEEDVFKMLEHVDKEAEEVEKEAKV 155
            |.|...:...|....|||                   ::..|:|.   ::.:..:.||| ...::
  Fly   115 AVETTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDT---IDFILADDEEV-VPGRI 175

  Fly   156 EEDDGGNVSVKMFDDDSSIESGNDNDHDLDFEPNSSDDDI-------------------PLAQRM 201
            |.::|..:.|...|:|.. |.|:::..|...:.|||...|                   .|.:.:
  Fly   176 ENNNGQEIVVTEDDEDLG-EDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHL 239

  Fly   202 RGPATGSG---PQQDRFSNLDKPK-----------------------------PRPRGRPKKIKP 234
            ......||   .:.|...||:|.:                             |   ..||..|.
  Fly   240 EFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCP---DCPKSFKT 301

  Fly   235 PPPEEEELSDSSSESDDSEDGTSRGDKPKRKRIPI-EERHLHR--IIDCHICHQKFKKAIRYEEH 296
            ....|..:..:.||..|........:......:.: ||:|..|  ...|.||.:.|.::...:.|
  Fly   302 QTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRH 366

  Fly   297 MKY----HNDLLPFQCKVETCKKGFTTANGLRIHI-DHAHTELSEVHACIAEGCGKTFPRVRLLT 356
            .||    .|:.....|||  |.:.|...:.||.|: .|..|::.:....:...|...|..:..|.
  Fly   367 QKYSSCSSNETDTMSCKV--CDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLN 429

  Fly   357 FHMKKVHGITKAAAPLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRD 421
            .|::...|       .:.|.|..||..|....|||||...||||: ||.|.:|.:.|.:...|..
  Fly   430 IHIRTHTG-------EKPFDCDLCDKKFSALVALKKHRRYHTGEK-PYSCTVCNQAFAVKEVLNR 486

  Fly   422 HLMRHAGIKNHVCPYCGVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHE-- 484
            |:.||.|.:.|.|..||.......:...|..||.  :.|.|.|||.....::.|..||| .|.
  Fly   487 HMKRHTGERPHKCDECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKFKTEKQLERHVK-THSRT 548

  Fly   485 KRKDFACQYCGKTFG-----KSH-----------------ACKVHERSHTGEKCCECKICGKIFL 527
            ||..|:|..|.:.|.     |.|                 |.|:.||:       :|.||.|.|.
  Fly   549 KRPVFSCAECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERT-------DCAICDKNFD 606

  Fly   528 CEKSLTKHLKT-HE-----------------KRDLPPAEPLRQQLNIPMPGQMSVPMPGQ----- 569
            ...:|.:|::| ||                 |:|:...|.:...||......:|....|.
  Fly   607 SSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVR 671

  Fly   570 -------------MPMQMQTDGLVPMD----PNQMPSEDMLKACGGGTAAVPPKPKNS------- 610
                         :.::.:|..::|:|    ..|:..|          |.|.|:.|..
  Fly   672 EFLVDEGDGAAQTITLENETYTILPLDGAIEGEQLTDE----------AGVKPEAKKEEAQVSPV 726

  Fly   611 -RRVQRVDI--SQLAGTAVNPIPSVSVPSWSPQV----NFTKKEGQHICPGCGRGFNNIGNMKLH 668
             ::.||..:  |..|..|.|...|.|...:|.::    :...||             |:|
  Fly   727 VKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILTEEDIKLKE-------------NVG----- 773

  Fly   669 YKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKI---C----------------GK 714
             |:|...|             ...||:.:.|.:..|:...||:   |                |.
  Fly   774 -KLIDMLV-------------DPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYAELDYGS 824

  Fly   715 HFRQETALKKHIKTHEKPNRRHVPERSAPTQITF---------RKLEPDAEPRNFDQYQDPAVER 770
            ..|:...|...:..|....:..:........|.:         ..|:.|.|..:.|:      |.
  Fly   825 RMREYCKLLFTVVIHNDSIKSLLNNFPIDDVIEYVLGDEDQDEGGLDKDNESHSGDE------EA 883

  Fly   771 AAATAELLAHQLEENEAKRK--AEIERQKIAAAACEQLTKLQQQQEIIK 817
            .:.|.|...:::.|...|::  |:.|:::|...|.::    ...:|:::
  Fly   884 VSVTGETKTNEIREKPEKKEVSAKSEKKEIVGKAVDK----DNSEEVVR 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	4/18 (22%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..414	CDD:290200	13/24 (54%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	462..483	CDD:275368	8/20 (40%)
		C2H2 Zn finger	491..511	CDD:275368	9/41 (22%)
		C2H2 Zn finger	519..539	CDD:275368	8/20 (40%)
		C2H2 Zn finger	652..673	CDD:275368	3/20 (15%)
		C2H2 Zn finger	681..701	CDD:275368	3/19 (16%)
		zf-H2C2_2	694..718	CDD:290200	7/42 (17%)
		C2H2 Zn finger	709..729	CDD:275368	6/38 (16%)
		tolA_full	724..>814	CDD:274303	15/100 (15%)
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	5/23 (22%)
		COG5048	<312..517	CDD:227381	59/214 (28%)
		C2H2 Zn finger	321..341	CDD:275368	2/19 (11%)
		zf-C2H2	348..368	CDD:278523	5/19 (26%)
		C2H2 Zn finger	350..368	CDD:275368	5/17 (29%)
		C2H2 Zn finger	382..402	CDD:275368	8/21 (38%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		zf-H2C2_2	428..451	CDD:290200	7/29 (24%)
		C2H2 Zn finger	443..463	CDD:275368	9/19 (47%)
		zf-H2C2_2	455..479	CDD:290200	13/24 (54%)
		COG5048	<467..620	CDD:227381	47/163 (29%)
		C2H2 Zn finger	471..491	CDD:275368	5/19 (26%)
		zf-H2C2_2	484..508	CDD:290200	9/23 (39%)
		C2H2 Zn finger	499..519	CDD:275368	4/19 (21%)
		C2H2 Zn finger	525..545	CDD:275368	8/20 (40%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	598..615	CDD:275371	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930