DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and CG5245

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	145/581 - (24%)
Similarity:	214/581 - (36%)	Gaps:	161/581 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 SNLDKPKPRPRGRPKKIKPPPPE--EEEL---SDSSSESDDS----EDGTSRG-DKPKRKRIP-- 268
            :|:|:       ||.|.:||..:  ||||   |:|..|..:|    |:..|.| |....|.:|
  Fly     4 ANVDQ-------RPVKDEPPQEDTFEEELIFISNSDFEELESEIKIENFCSYGKDLEPVKGVPSK 61

  Fly   269 --------IEERHLHRIID---CHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANG 322
                    .::|.|.:..|   |..|.:.|.:....|.|::.|.:..||:|  ..|.|.|    |
  Fly    62 LKTCKSKIAKKRPLRKQTDTFKCTQCQKTFTRKENLESHLRLHAEERPFEC--SHCSKSF----G 120

  Fly   323 LRIHID-HAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRC 386
            .|.|.. |........|.|  ..|.|||.:...|..|:.:..|       .|.|.||:|.|.|..
  Fly   121 RRTHYKRHLLKHEKRPHKC--SHCSKTFTQNSSLKQHLHEHTG-------ERPFKCTQCSTSFAR 176

  Fly   387 PTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHI 451
            .:.|:.|:..|: ||.|:.|..|.|.|..||.|::||..|...:...|.:|......|.....|:
  Fly   177 KSHLQVHLRTHS-EERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHL 240

  Fly   452 LTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKS---------HACK-- 505
            |||. |:.|||.||........:|..|:: ||.....|.|.:|.:||.::         ||.|
  Fly   241 LTHA-ERSFKCTQCPKTFLQNDSLQIHLR-VHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEP 303

  Fly   506 -----------------VHERSHTGEKCCECKICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQ 553
                             ||.|.||.|:..:|..|.|.|..:..|.:|.:.|
  Fly   304 LKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVH-------------- 354

  Fly   554 LNIPMPGQMSVPMPGQMPMQMQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDI 618
                         .|:.|.:                   ...|.        |....|...||.:
  Fly   355 -------------TGERPFK-------------------CTHCF--------KDFKCRTHLRVHM 379

  Fly   619 SQLAGTAVNPIPSVSVPSWSPQVNFTKKE-----------------GQHICPGCGRGFNNIGNMK 666
            ....|..|            |:.::..||                 .|..||.|.:.:.....:.
  Fly   380 LDHIGEKV------------PKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLH 432

  Fly   667 LHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKHIK 727
            :|.: .|.....|.|..|.|.|:::...:.|...||||||::|..|...:.|:::|.:|::
  Fly   433 MHLR-THTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	6/18 (33%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..414	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..483	CDD:275368	5/20 (25%)
		C2H2 Zn finger	491..511	CDD:275368	10/47 (21%)
		C2H2 Zn finger	519..539	CDD:275368	6/19 (32%)
		C2H2 Zn finger	652..673	CDD:275368	4/20 (20%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		zf-H2C2_2	694..718	CDD:290200	9/23 (39%)
		C2H2 Zn finger	709..729	CDD:275368	5/19 (26%)
		tolA_full	724..>814	CDD:274303	1/4 (25%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	119/488 (24%)
		C2H2 Zn finger	84..104	CDD:275368	5/19 (26%)
		C2H2 Zn finger	112..132	CDD:275368	8/25 (32%)
		C2H2 Zn finger	139..159	CDD:275368	7/21 (33%)
		C2H2 Zn finger	167..187	CDD:275368	7/19 (37%)
		zf-H2C2_2	179..204	CDD:290200	10/25 (40%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	250..270	CDD:275368	5/20 (25%)
		C2H2 Zn finger	278..298	CDD:275368	4/19 (21%)
		C2H2 Zn finger	306..326	CDD:275368	3/19 (16%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	5/27 (19%)
		C2H2 Zn finger	390..410	CDD:275368	2/19 (11%)
		C2H2 Zn finger	418..438	CDD:275368	4/20 (20%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1382
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050