DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and topi

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	752	Identity:	159/752 - (21%)
Similarity:	233/752 - (30%)	Gaps:	270/752 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DKEAEEVEKEAKVEEDDGGNVSVKMFDDDSSIESGNDNDHD------------LDFE----PNSS 191
            |.:||::    |:.:...|..|.||..:.|.......|...            :.|:    .|.|
  Fly    95 DPQAEQM----KIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHS 155

  Fly   192 DDDIPLAQRMRGPATGSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSSSE-------- 248
            .:..|:...:        |||:          :|...|....||.|    ||..:||
  Fly   156 CEAKPIEVAV--------PQQE----------KPHLVPTVSAPPAP----LSKPASERVIRENQV 198

  Fly   249 ------SDDSEDGTSRGDKPKRKRI---PIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHN-DL 303
                  .|:.:...:.|.:..||..   |.|         |.:|.:||..|.....||:.|. ||
  Fly   199 RLRRYIKDEMKYDLATGIESSRKNAAKGPNE---------CTMCDRKFVHASGLVRHMEKHALDL 254

  Fly   304 LPFQCKVETCKKGFT-TANGLRIHIDHAHTELSEVHACIAEGCGKTF--PRVRLLTFHMKKVHGI 365
            :|.|    |.::..| .|.||.:           |..|  ..||:.|  |:|...       ||:
  Fly   255 IPSQ----TSEQPHTIPAAGLHV-----------VVKC--NSCGRIFYDPQVAFR-------HGL 295

  Fly   366 -------TKAAAPLRDFPCTECD-------------------TVFRCPTALKKHMYKH--TGEEL 402
                   |...:|:...|....|                   |..:.....||.|:..  .|..|
  Fly   296 IHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVL 360

  Fly   403 PYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHILTH------------- 454
              .|..|...|...:.|..|...|...:...|..|.:...|.:|.:.|..|.
  Fly   361 --QCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNV 423

  Fly   455 TKEKKFKCRQCDHASHNKQALSNH-------VKVVHEKRKD--FACQYCGKTFGKSHACKVH-ER 509
            |..:.|.|..|:....|...|..|       ...::|..|.  ..|.:|...|..:|....| |.
  Fly   424 TLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEE 488

  Fly   510 SHTGEKCCE---------------CKICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMP 559
            .|..:|..|               |.||||.:.....|.:||:.|:
  Fly   489 KHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQ------------------- 534

  Fly   560 GQMSVPMPGQMPMQMQTDG-----LVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDIS 619
                    |..|...|.:.     .:..|.|     |.::.|..|
  Fly   535 --------GVKPFVCQEENCDRKFTIRPDLN-----DHIRKCHTG-------------------- 566

  Fly   620 QLAGTAVNPIPSVSVPSWSPQVNFTKKEGQHICPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFC 684
                                       |..::|..||:.|.. |::...:::||...:.:.|..|
  Fly   567 ---------------------------ERPYLCLVCGKRFLT-GSVFYQHRLIHRGERRYECEEC 603

  Fly   685 PKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKHIKTHEKPNRRHVPERSAPTQITFR 749
            .|||.:|..|::|:.|||||||:.|..|.|.|||.....|||:....    |:
  Fly   604 GKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHS----HL------------ 652

  Fly   750 KLEPDAEPRNFDQYQDPAVERAAATAELLAHQLEENE 786
                ||..|...|.|...:|.||| .:..:|..|:.:
  Fly   653 ----DANSRLMMQMQKFQLETAAA-QKAQSHNPEQQD 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	5/20 (25%)
		C2H2 Zn finger	377..397	CDD:275368	5/38 (13%)
		zf-H2C2_2	389..414	CDD:290200	7/26 (27%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..483	CDD:275368	5/27 (19%)
		C2H2 Zn finger	491..511	CDD:275368	6/20 (30%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		C2H2 Zn finger	652..673	CDD:275368	5/20 (25%)
		C2H2 Zn finger	681..701	CDD:275368	8/19 (42%)
		zf-H2C2_2	694..718	CDD:290200	13/23 (57%)
		C2H2 Zn finger	709..729	CDD:275368	9/19 (47%)
		tolA_full	724..>814	CDD:274303	15/63 (24%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/28 (29%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	60/276 (22%)
		C2H2 Zn finger	469..490	CDD:275368	6/20 (30%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	15/82 (18%)
		C2H2 Zn finger	541..561	CDD:275368	4/24 (17%)
		zf-H2C2_2	555..581	CDD:290200	10/77 (13%)
		C2H2 Zn finger	572..592	CDD:275368	5/20 (25%)
		zf-H2C2_2	585..609	CDD:290200	7/23 (30%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930