DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and Meics

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	160/762 - (20%)
Similarity:	249/762 - (32%)	Gaps:	248/762 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CRICLNHLQNDAAYDLYLVPGLSKKLC------FCTSLSVE----QNDGFPKNLCTLCYTKLNEL 67
            ||.|..|  :....||:     ||::.      ...|:..|    :.|..|:.:|..|.......
  Fly    21 CRACAEH--SSILVDLF-----SKEISDPPIWEMLNSILPEICRVKRDEMPQKICPTCLVAAQNA 78

  Fly    68 HDFQKQCVDSVQKFQDLVA-----SNVFACQSSFDVFDPNVAVQDYPAEEEDHVNYDPLLNHKME 127
            ..|:.:|..|.|.|..|:.     ||:..........:|.:..:....|       |||..:..:
  Fly    79 FHFRHKCEQSFQFFSQLLQLDKSNSNLSRSHCRRGTMNPLIPFEIVGCE-------DPLDTNVTK 136

  Fly   128 LIENEEDVFKML-EHVD------KEAEEVEK-------EAKVEEDDGGNVSVKMFDDDSSIESGN 178
            |..|..||...: |..|      :|:|.:::       :.|.|::    ||::...:|:..|..:
  Fly   137 LDANRPDVKTDIDEPTDGKATNGQESEPLQEVFEITMNDIKTEDE----VSIQETFEDAFDEEND 197

  Fly   179 DNDHDLDFEP-------NSSDDDIPLAQRMRGPATGSGPQQDRFSNLDKPKPRPRGRPKKIKPPP 236
            :|:.|.:.|.       ::.|.|.|......|..|..|..|..
  Fly   198 NNNTDSEREDSDQWTVGSTEDQDEPWIPGGGGRQTVGGNNQSL---------------------- 240

  Fly   237 PEEEELSDSSSESDDSEDGTSRGDKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHN 301
                 |......|..::...:|.....:::...::.||     |..|.:.|:...:...|.:.|.
  Fly   241 -----LCTECGVSYSTQKALARHVAKHKEQGDTQKPHL-----CDFCGRGFRTNAQLTTHRRRHT 295

  Fly   302 DLLPFQCKVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGIT 366
            ...||:|.:  |.|.:|....|:.|: |.|.|                          :|.|
  Fly   296 GERPFKCPL--CPKAYTHGPTLKSHM-HTHDE--------------------------EKGH--- 328

  Fly   367 KAAAPLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKN 431
                     .|.:||..|.....|:.|:.:||||. ||.|..|.:.|..||.|:.|...|...:.
  Fly   329 ---------KCPQCDKTFYTRGNLRAHIQRHTGER-PYKCPDCPQTFAKNSGLKLHSRLHKEERP 383

  Fly   432 HVCPYCGVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGK 496
            ..|..||.|....|....|:..|..:::|||..||.:...|..:..|.: .|...|.|.|:.||:
  Fly   384 FKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQR-THSGIKPFKCEECGQ 447

  Fly   497 TFGKSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQ 561
            .|..:|..|.|.|.|||||..:|..|||.|...:||.||...|
  Fly   448 AFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWH---------------------- 490

  Fly   562 MSVPMPGQMPMQMQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAV 626
                                :|.|..|.:
  Fly   491 --------------------VDNNDRPFK------------------------------------ 499

  Fly   627 NPIPSVSVPSWSPQVNFTKKEGQHICPGCGRGFNN----IGNMKLHY-----KIIHEKVKDFACR 682
                                     |..|.:.::.    .|:.|.|.     |.:|:      |.
  Fly   500 -------------------------CSQCPKAYDTQQSLRGHEKTHKNPDEPKTLHQ------CP 533

  Fly   683 FCPKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKHIKTH 729
            .|..||:..:.|..|...|. .:|..|..|.:.|..:.:||||::.|
  Fly   534 HCDVRFALKKTLDKHITSHK-IRPHPCPQCPEGFFSQKSLKKHLRLH 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871	19/79 (24%)
		C2H2 Zn finger	343..362	CDD:275368	0/18 (0%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..414	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	462..483	CDD:275368	5/20 (25%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368	9/19 (47%)
		C2H2 Zn finger	652..673	CDD:275368	6/29 (21%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		zf-H2C2_2	694..718	CDD:290200	7/23 (30%)
		C2H2 Zn finger	709..729	CDD:275368	7/19 (37%)
		tolA_full	724..>814	CDD:274303	3/6 (50%)
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	19/80 (24%)
		C2H2 Zn finger	242..262	CDD:275368	2/19 (11%)
		C2H2 Zn finger	274..294	CDD:275368	4/19 (21%)
		zf-H2C2_2	287..311	CDD:290200	7/25 (28%)
		C2H2 Zn finger	302..322	CDD:275368	7/22 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..366	CDD:290200	10/24 (42%)
		C2H2 Zn finger	358..378	CDD:275368	7/19 (37%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		COG5048	<395..583	CDD:227381	62/296 (21%)
		zf-C2H2	412..434	CDD:278523	7/22 (32%)
		C2H2 Zn finger	414..434	CDD:275368	5/20 (25%)
		zf-H2C2_2	426..451	CDD:290200	8/25 (32%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	4/19 (21%)
		C2H2 Zn finger	532..552	CDD:275370	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275370	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1382
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960