DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and pita

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	889	Identity:	168/889 - (18%)
Similarity:	270/889 - (30%)	Gaps:	315/889 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LCRICLNHLQNDAAYD----LYLVPGLSKKLCFCTSLSVEQNDGFPKNLCTLCYTKLNELHDFQK 72
            :||.||...:..:.::    :.....|..::...|::.|...||.|.::|..|.......:.|::
  Fly    17 VCRFCLTEQKLASIFEENPRVKTTANLPLQIMAITAIEVYAGDGMPGHICLECRLLFEHCYRFKQ 81

  Fly    73 QC-------------------VDSVQKFQDLVAS---------------------NVFACQSSFD 97
            .|                   ::..:....:|||                     |..|..||..
  Fly    82 MCKRAETLLRQYPLTGNWPSPLEKPRAPMTMVASKKLLVVPAKTAEPSETPKKLLNTMAKSSSQV 146

  Fly    98 VFD-----------PNVAVQDYPAEEEDHVNYDPLLNHKMELIENEEDVFKMLEHVDKEAEEVEK 151
            :.:           |.......|.....|. |:..:::..||  :.:||..|||.:   |.|:||
  Fly   147 IIEDVQVLESAMVTPRTVAGSSPVPRRSHA-YELKVDNNQEL--SMDDVQSMLEDM---ASELEK 205

  Fly   152 EAKVEEDDGGNVSVKMFDDDSSIESGNDNDHDLDFEPNSSDDDIPLAQRMRGPATGSGPQQDRFS 216
            |..........|..|:. :.|||...|                       :|||   .|.:.|.:
  Fly   206 EFPDIPQKASPVKPKVL-NKSSIRILN-----------------------KGPA---APVEPRLA 243

  Fly   217 NLDKPKPRPRGRPKKIKPPPPEEEELSDSSSESDDSEDGTSRGDKPKRKRIPIEERHLHRIIDCH 281
            . .|.|....|....:       .|:.||....||.:|.|...:
  Fly   244 T-PKVKRDDSGNVAIV-------TEVLDSDLPLDDQDDPTKNAE--------------------- 279

  Fly   282 ICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCG 346
                                       ||.|                       :|..|  ..|.
  Fly   280 ---------------------------KVAT-----------------------DVFPC--PDCE 292

  Fly   347 KTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGK 411
            ::||..:||     ::|.:....:  |.|.|..|:..|.....|.||.:.||||. |:.|.||.|
  Fly   293 RSFPLQQLL-----EIHRLNHTRS--RSFQCLLCEKSFFSKYDLAKHNFVHTGER-PFKCAICSK 349

  Fly   412 RFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALS 476
            .|...:.|..|...|..:...:|.||.....:|||...|...|.|::.|:|..|..:...||.|.
  Fly   350 AFTRKALLHRHERTHTDVPKFICVYCEKPFLSRQEMEKHAERHQKKRPFQCGVCTKSFAFKQGLE 414

  Fly   477 NHVKVVHEKRKDFACQYCGKTFGKSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKTHEK 541
            .| :.||.....|.||:|.::|..:.....|..:|.|::...||.|.|.::....|::||:||
  Fly   415 RH-ETVHSTNLPFPCQHCERSFSTASKLARHLVAHAGKRAYPCKYCHKSYMLSHHLSRHLRTH-- 476

  Fly   542 RDLPPAEPLRQQLNIPMPGQMSVPMPGQMPMQMQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPK 606
                                            .||
  Fly   477 --------------------------------TQT------------------------------ 479

  Fly   607 PKNSRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGQHICPGCGRGFNNIGNMKLHYKI 671
                                                   .:...:|..|...::|..:: |.:.:
  Fly   480 ---------------------------------------SDASFVCSECKVSYSNYNDL-LDHAL 504

  Fly   672 IHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKHIKTHEKPNRRH 736
            || ......|..|.|:......:..|...|...:...|:.|...|..:..|::||:..      |
  Fly   505 IH-ATASLKCPMCRKQIEDIDSVESHMDQHKQSERHACEFCDHIFLTQKCLQRHIEDD------H 562

  Fly   737 VPERSAPTQITFRKLEPDAE--------PRNFDQYQD-PAVERAAATAELLA-------HQLEEN 785
            |.|.. |.|..|   |.|.|        ..:.|.::| ..|::.....|.|.       |..:.:
  Fly   563 VVEME-PYQNEF---EDDGEGEGGVDEKEEHLDDFEDMDNVKQEEFVTEYLEDDALYEDHLDDSD 623

  Fly   786 EA-----KRKAEIERQKIAAAACEQLTKLQQQQEIIKATTSYDG 824
            |:     .::.:....|.|..:..| |:.:..|.|.:.|...:|
  Fly   624 ESFTPPPPKQRKTNPPKDAQQSVRQ-TRSRDAQRITQKTGKNEG 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871	14/93 (15%)
		C2H2 Zn finger	343..362	CDD:275368	5/18 (28%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..414	CDD:290200	12/24 (50%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	462..483	CDD:275368	6/20 (30%)
		C2H2 Zn finger	491..511	CDD:275368	5/19 (26%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	652..673	CDD:275368	4/20 (20%)
		C2H2 Zn finger	681..701	CDD:275368	4/19 (21%)
		zf-H2C2_2	694..718	CDD:290200	5/23 (22%)
		C2H2 Zn finger	709..729	CDD:275368	6/19 (32%)
		tolA_full	724..>814	CDD:274303	22/110 (20%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871	14/74 (19%)
		COG5048	<281..506	CDD:227381	72/362 (20%)
		C2H2 Zn finger	288..308	CDD:275368	7/26 (27%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	13/25 (52%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..388	CDD:275370	6/15 (40%)
		C2H2 Zn finger	400..420	CDD:275368	6/20 (30%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..506	CDD:275368	4/20 (20%)
		HARE-HTH	<566..625	CDD:294801	12/62 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930