DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and cg

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	682	Identity:	157/682 - (23%)
Similarity:	229/682 - (33%)	Gaps:	208/682 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 KIKPPPPE---EEELSDSSSESDDSEDGTSRGDKP-----------------KRKRIPIEER-HL 274
            |::|...|   :.||.:|...|:  .|.|.:.::|                 ...|:...|| |:
  Fly   259 KLEPGTLELSPKTELQESMHFSE--TDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHI 321

  Fly   275 HRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHAHTELSEVHA 339
                 |..|.:.|........|:..|:...|:||  :.|||.||..:.|..|        |.||:
  Fly   322 -----CTHCGKSFAHKHCLNTHLLLHSTERPYQC--QECKKSFTLKHHLLTH--------SRVHS 371

  Fly   340 ----CIAEGCGKTFPRVRLLTFHMK---------------------------KVHGITKAAAPLR 373
                .:.:.||:.||..|.|..|.|                           :.||      .|.
  Fly   372 RERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHG------SLN 430

  Fly   374 DFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMR-HAGIKNHVCPYC 437
            .|.|.||...|.....|..|...|  .::|:.|.:|||.|:....|..|:.| |.|.:.|.|..|
  Fly   431 PFVCAECGASFPRKFQLVNHGRIH--GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSC 493

  Fly   438 GVGKTTRQEWNAHILT-------HTKEKKFKC-RQCDHASHNKQALSNH---VKVVHE------- 484
            |.|..|:.|.:.|:.|       :|....... :|...|.|::.....|   :.||..
  Fly   494 GEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLL 558

  Fly   485 ----------KRKDFACQYCGKTFGKSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKTH 539
                      .|..|.|:.||..|....|..:|.|.|||:|.....:|        :||..|..|
  Fly   559 TVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLC--------ALTAALPGH 615

  Fly   540 EKRDLPPAEPLRQQLNIPMPGQMSVPMP---GQMPMQMQTDGLVPMDPNQMPSEDMLKACGGGT- 600
               .|..|     .||   ||.:....|   ||.|:.:|    :.....|:.|:..|......|
  Fly   616 ---FLSTA-----SLN---PGTVVTANPNLVGQSPVPVQ----IISSTGQVMSQTTLVQAANSTH 665

  Fly   601 -----AAVPPKPKNSRR--VQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGQHICPGCGRG 658
                 .|||..|.:.::  :|.|...|.............|.|.:|    ..|...|.|..||:|
  Fly   666 PQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAP----ANKPKSHFCASCGKG 726

  Fly   659 FNNIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKI------CGKHFR 717
            |                            .:|..:::|:.....|    .|.:      |||.|.
  Fly   727 F----------------------------AAKHGLMQHNRRHPNG----GCTVRTHVCECGKAFF 759

  Fly   718 QETALKKHIKTHEKPNRRHVPERSAPTQITFRKLEPDAEPRNFDQYQDPAVERAAATAELLAHQL 782
            |    |.|:..|:   |:|:..:.|                 ..|.|:.|.::..|||.  ..|.
  Fly   760 Q----KNHLMLHQ---RQHLETKPA-----------------ISQQQEAATQQQLATAG--EQQQ 798

  Fly   783 EENEAKRKAEIERQKIAAAACEQLTKLQQQQE 814
            .:.:.....:|..:.|....|..:....||||
  Fly   799 VQVQIMPDGQIHGKVIKYEICRNVMPEDQQQE 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	8/45 (18%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..414	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	8/20 (40%)
		C2H2 Zn finger	434..454	CDD:275368	8/26 (31%)
		C2H2 Zn finger	462..483	CDD:275368	5/24 (21%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	4/19 (21%)
		C2H2 Zn finger	652..673	CDD:275368	5/20 (25%)
		C2H2 Zn finger	681..701	CDD:275368	2/19 (11%)
		zf-H2C2_2	694..718	CDD:290200	7/29 (24%)
		C2H2 Zn finger	709..729	CDD:275368	8/25 (32%)
		tolA_full	724..>814	CDD:274303	17/89 (19%)
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	22/98 (22%)
		C2H2 Zn finger	294..314	CDD:275368	1/19 (5%)
		zf-H2C2_2	306..331	CDD:290200	7/29 (24%)
		C2H2 Zn finger	322..342	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..370	CDD:275368	9/29 (31%)
		zf-H2C2_2	362..385	CDD:290200	7/30 (23%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		zf-H2C2_2	390..415	CDD:290200	3/24 (13%)
		C2H2 Zn finger	406..426	CDD:275368	0/19 (0%)
		SIR2	<425..>465	CDD:294129	13/47 (28%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	27/111 (24%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	7/47 (15%)
		C2H2 Zn finger	752..771	CDD:275368	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100