DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and Zfp358

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001101798.1	Gene:	Zfp358 / 360754	RGDID:	1310416	Length:	652	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	131/589 - (22%)
Similarity:	191/589 - (32%)	Gaps:	202/589 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 PATGSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSSSESDDS-EDGTSRGDKPKRKRI 267
            |..|..|...  .:||   |.|:...:..:.|.||.|:|:..|.:.|.| ||     .:|:.:..
  Rat   105 PLYGDLPSDP--EDLD---PSPKAPDRISESPEPEPEDLNTVSEDGDASLED-----PEPEAEEA 159

  Fly   268 P--------IEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVE-----------TC 313
            |        ::.|                             ||.|.....:           ..
  Rat   160 PPSMLGKPDLDSR-----------------------------DLDPTSSSFDLDPDVIGPVPLVL 195

  Fly   314 KKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCT 378
            .....|.:....|:|...:.|:.....:|.......|                ..|:|.|.|.|.
  Rat   196 DPSDDTLSPAAPHVDSLPSSLTATPEILATSSAVVLP----------------APASPPRPFSCP 244

  Fly   379 ECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTT 443
            :|...||..:.|.:|...|:||: ||.|..|||.|...:.|..|...|.|.:.:.|..||.....
  Rat   245 DCGRAFRRSSGLSQHRRTHSGEK-PYRCPDCGKSFSHGATLAQHRGIHTGARPYQCAACGKAFGW 308

  Fly   444 RQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSHACKVHE 508
            |.....|..:|:.||...|..|..|..:...|:.|:: .|...:...|..|.|.||:..|...|.
  Rat   309 RSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLR-THGGPRPHKCPVCAKGFGQGSALLKHL 372

  Fly   509 RSHTGEKCCECKICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQMSVPMPGQMPMQ 573
            |:||||:...|..|||.|....:|.:|.:||
  Rat   373 RTHTGERPYPCPQCGKAFGQSSALLQHQRTH---------------------------------- 403

  Fly   574 MQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAVNPIPSVSVPSWS 638
                                                              ||..|
  Rat   404 --------------------------------------------------TAERP---------- 408

  Fly   639 PQVNFTKKEGQHICPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTG 703
                       :.||.||:.|....|::.|.: ||...:.:||..|.|.|.::..|..|..:|:|
  Rat   409 -----------YRCPHCGKAFGQSSNLQHHLR-IHTGERPYACPHCSKAFGQSSALLQHLHVHSG 461

  Fly   704 EKPFECKICGKHFRQETALKKHIKTHEKPNRRHVPERSA-----------------PTQITFRKL 751
            |:|:.|::|||.|.|.::|.||.:.||..........:|                 |.||:|  |
  Rat   462 ERPYRCQLCGKAFGQASSLTKHKRVHEGAAAAAAAAAAAAAGLGLGPGLSPVSMMRPGQISF--L 524

  Fly   752 EPDA 755
            .|||
  Rat   525 GPDA 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	1/18 (6%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		zf-H2C2_2	389..414	CDD:290200	11/24 (46%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..483	CDD:275368	5/20 (25%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	652..673	CDD:275368	7/20 (35%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		zf-H2C2_2	694..718	CDD:290200	11/23 (48%)
		C2H2 Zn finger	709..729	CDD:275368	9/19 (47%)
		tolA_full	724..>814	CDD:274303	13/49 (27%)
Zfp358	NP_001101798.1	COG5048	<236..429	CDD:227381	68/299 (23%)
		zf-C2H2	241..263	CDD:278523	7/21 (33%)
		C2H2 Zn finger	243..263	CDD:275368	6/19 (32%)
		zf-H2C2_2	256..280	CDD:290200	12/24 (50%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		zf-H2C2_2	284..306	CDD:290200	7/21 (33%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		zf-H2C2_2	312..334	CDD:290200	6/21 (29%)
		C2H2 Zn finger	327..347	CDD:275368	5/20 (25%)
		zf-H2C2_2	340..362	CDD:290200	6/22 (27%)
		C2H2 Zn finger	355..375	CDD:275368	8/19 (42%)
		zf-H2C2_2	367..390	CDD:290200	11/22 (50%)
		zf-C2H2_8	382..460	CDD:292531	28/183 (15%)
		C2H2 Zn finger	383..403	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..418	CDD:290200	11/127 (9%)
		C2H2 Zn finger	411..431	CDD:275368	7/20 (35%)
		zf-H2C2_2	423..446	CDD:290200	8/23 (35%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		zf-H2C2_2	451..474	CDD:290200	10/22 (45%)
		zf-C2H2	465..487	CDD:278523	9/21 (43%)
		C2H2 Zn finger	467..487	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910