DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and CG17328

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_609786.2	Gene:	CG17328 / 34962	FlyBaseID:	FBgn0028895	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	128/654 - (19%)
Similarity:	191/654 - (29%)	Gaps:	306/654 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YSIHSLCRICLNHLQ---NDAAYDLYLVPGLSKKLCFCTSLSVEQNDGFPKNLCTLCYTKLNELH 68
            |:||.:||:||..|.   :..:.|..::|  |..|..|..:.|.:.||.|..:|..|..:|....
  Fly     3 YNIHKICRVCLEELHPVTSIYSTDFAMMP--SVMLMQCAKIRVFKTDGLPSVICNNCIYRLGVAF 65

  Fly    69 DFQKQCVDSVQKFQDLVASNVFACQSSFDVFDPNVAVQDYPAEEEDHVNYDPLLNHKMELIEN-E 132
            .|:::|.:|                                         |..|...:.::|: .
  Fly    66 HFKQECENS-----------------------------------------DLRLRQYLGILESWR 89

  Fly   133 EDVFKMLEHVDKEAEEVEKEAKVEEDDGGNVSVKMFDDDSSIESGNDNDHDLDFEPNSSDDDIPL 197
            :|.....:.|:|                                                   ||
  Fly    90 QDAATNTDFVEK---------------------------------------------------PL 103

  Fly   198 AQRMRGPATGSGPQQDRFSNLDKP------KPRPRGRPKKIKPPPPEEEELSDSSSESDDSEDGT 256
            .           ||:|  |:.::|      |.|.|.:.|     ||||.:
  Fly   104 L-----------PQRD--SDEEEPVDAKVSKRRSRYQRK-----PPEEHK--------------- 135

  Fly   257 SRGDKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTAN 321
            .||.||..| :|      |   .|:.||:.||...:..:|::.|....|:||..  |.:.|....
  Fly   136 KRGPKPVPK-MP------H---TCYECHKSFKCIAQLTQHIRTHTGEKPYQCSF--CIQRFAQKY 188

  Fly   322 GLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRC 386
            .|::|                   .:|
  Fly   189 NLKVH-------------------ERT-------------------------------------- 196

  Fly   387 PTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHI 451
                      |||:: |:.|.||.|:|......:.|...|.|:::.||..|..|..|..:.:.|:
  Fly   197 ----------HTGDK-PFQCEICSKQFSALGNFQAHQKIHLGVRDQVCSLCQKGFYTAGDLSKHM 250

  Fly   452 LTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFG-----KSHACKVH--ER 509
            :|||                  .:.||    |       |..|||.|.     ::|..|:|  |.
  Fly   251 ITHT------------------GIKNH----H-------CDVCGKAFSRRRDMRTHKLKLHPLES 286

  Fly   510 S-------------------------HTGEKCCECKICGKIFLCEKSLTKHLKTHEKRD------ 543
            |                         |...||.:   |.|.|....||:.|.:||...:
  Fly   287 STNHDIVDDDDDEAIDTDPVGLDTLDHAHFKCPD---CDKAFDTADSLSLHFRTHAANNNLLNLP 348

  Fly   544 LPPAEPLRQQLNIPMPGQMSVPMPG-QMPMQMQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKP 607
            ||||.|:....:......:..|.|. ||.|......|.|..|                  .||.|
  Fly   349 LPPAPPMSHHYHHDALHHLGPPNPATQMGMAAMAHMLAPPPP------------------PPPTP 395

  Fly   608 KNSR 611
            ...|
  Fly   396 SEGR 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871	20/73 (27%)
		C2H2 Zn finger	343..362	CDD:275368	1/18 (6%)
		C2H2 Zn finger	377..397	CDD:275368	0/19 (0%)
		zf-H2C2_2	389..414	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..483	CDD:275368	2/20 (10%)
		C2H2 Zn finger	491..511	CDD:275368	10/51 (20%)
		C2H2 Zn finger	519..539	CDD:275368	6/19 (32%)
		C2H2 Zn finger	652..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		zf-H2C2_2	694..718	CDD:290200
		C2H2 Zn finger	709..729	CDD:275368
		tolA_full	724..>814	CDD:274303
CG17328	NP_609786.2	zf-AD	8..80	CDD:214871	22/114 (19%)
		COG5048	146..>211	CDD:227381	24/143 (17%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		C2H2 Zn finger	177..197	CDD:275368	6/88 (7%)
		zf-H2C2_2	189..213	CDD:404364	11/91 (12%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		zf-H2C2_2	245..270	CDD:404364	12/53 (23%)
		C2H2 Zn finger	261..282	CDD:275368	7/20 (35%)
		C2H2 Zn finger	318..338	CDD:275368	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930