DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and crol

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	167/687 - (24%)
Similarity:	235/687 - (34%)	Gaps:	213/687 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 ERHLHR-----IIDCHICHQKFKKAIRYEEHMKYHNDLLPFQC---------------------- 308
            |||:.|     ...|.||.:.|.:....:.|.:.|....||:|
  Fly   293 ERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTG 357

  Fly   309 ----KVETCKKGFTTANGLRIHIDHA--HTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITK 367
                :.:.|||.||....   :::|.  ||..:. |.|  :.|||.:.|...|..||:.....|
  Fly   358 ETPHRCDICKKSFTRKEH---YVNHYMWHTGQTP-HQC--DVCGKKYTRKEHLANHMRSHTNET- 415

  Fly   368 AAAPLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNH 432
                  .|.|..|...|........|:..||| |.|:.|:.|.|.|.....|.:|:.:|.|...|
  Fly   416 ------PFRCEICGKSFSRKEHFTNHILWHTG-ETPHRCDFCSKTFTRKEHLLNHVRQHTGESPH 473

  Fly   433 VCPYCGVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKT 497
            .|.||....|.::....||..||.|..|||..|..|...|..:.|||: .|.......|.||.||
  Fly   474 RCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVR-QHTGESPHKCTYCTKT 537

  Fly   498 FGKSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKTHEKRDLPPAE------PLRQQLNI 556
            |.:......|.|.|||:....|..|.|.|..::.||.|::.|........|      ..::.||.
  Fly   538 FTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNN 602

  Fly   557 PMPGQMSVPMPGQMPMQMQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQL 621
            .|                           :..|.|....|.     |..||
  Fly   603 HM---------------------------RQHSSDNPHCCN-----VCNKP-------------- 621

  Fly   622 AGTAVNPIPSVSVPSWSPQVNFTKKEGQHI---------------CPGCGRGFNNIGNMKLHYKI 671
                                 ||:||  |:               |..||:.|...||:..|.:
  Fly   622 ---------------------FTRKE--HLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQR- 662

  Fly   672 IHEKVKD----FACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGKHFRQETALKKHIKTHE-- 730
            .|.|.::    |||..|||.|.....|..|...|:||||..|.:|.|.|.:...||:|:|.:.
  Fly   663 SHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPD 727

  Fly   731 -----KPNRRH-------------------VPERSAPT------QITFR--------KLEPDAEP 757
                 .|...|                   :|..||.|      |||..        :|.|...|
  Fly   728 AMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAGGAGAVQLTPGLVP 792

  Fly   758 --------RNFDQYQDPAVERAAATA--------------------ELLAHQLEENEAKRKAEIE 794
                    .|....|....::|||.|                    ...|||  :::.:..|:.:
  Fly   793 LVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQ--QHQQQVAAQHQ 855

  Fly   795 RQKIAAAACEQLTKLQQQQEIIKATTSYDGYYAQKAQ 831
            :|...||..:|..:|||||::::.:.....::.|:.|
  Fly   856 QQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQ 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	7/18 (39%)
		C2H2 Zn finger	377..397	CDD:275368	4/19 (21%)
		zf-H2C2_2	389..414	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	462..483	CDD:275368	7/20 (35%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	652..673	CDD:275368	7/20 (35%)
		C2H2 Zn finger	681..701	CDD:275368	7/19 (37%)
		zf-H2C2_2	694..718	CDD:290200	11/23 (48%)
		C2H2 Zn finger	709..729	CDD:275368	8/19 (42%)
		tolA_full	724..>814	CDD:274303	32/157 (20%)
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	3/5 (60%)
		COG5048	300..723	CDD:227381	129/507 (25%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	1/19 (5%)
		C2H2 Zn finger	363..383	CDD:275368	6/22 (27%)
		C2H2 Zn finger	391..411	CDD:275368	8/21 (38%)
		C2H2 Zn finger	419..439	CDD:275368	4/19 (21%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/20 (35%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	4/46 (9%)
		C2H2 Zn finger	615..636	CDD:275368	9/62 (15%)
		C2H2 Zn finger	644..664	CDD:275368	7/20 (35%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930