DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and CG2120

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster

Alignment Length:	354	Identity:	86/354 - (24%)
Similarity:	122/354 - (34%)	Gaps:	130/354 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 RCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNA 449
            |.||. |:|  :.||::  :.|:||.:||.....||.|.|.|...|.|||..||.|.....:...
  Fly    85 RTPTT-KRH--RTTGKD--HTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRI 144

  Fly   450 HILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSHACKVHERSHTGE 514
            |.:|||.|:..|                             |..|||.|..::...||.|.||||
  Fly   145 HAVTHTAERPHK-----------------------------CDICGKGFRYANYLTVHRRLHTGE 180

  Fly   515 K-----CCECKICGKIFLCEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQMSVPMPGQMPMQM 574
            |     ..:|.:........:..|| |:...:.|..|..||.:|
  Fly   181 KPYPCLATDCHLSFHSIHARRIHTK-LRHAAQTDPDPEHPLAEQ--------------------- 223

  Fly   575 QTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAVNPIPSVSVPSWSP 639
                                                   ::.|.|.|:.|
  Fly   224 ---------------------------------------EQRDTSALSFT--------------- 234

  Fly   640 QVNFTKKEGQHICPGCGRGFNNIGNMKLHYKIIHEKVKDFAC--RFCPKRFSKAQILRHHEWIHT 702
                        ||.|.|...:...:.:|.| .|...:||.|  ..|.|||..|..|:||:..||
  Fly   235 ------------CPVCSRVLTDQCYLSIHLK-RHYNQRDFPCPQPECGKRFFSASELKHHQIAHT 286

  Fly   703 GEKPFECKICGKHFRQETALKKHIKTHEK 731
            .::||.|.:|...|.:::..|:|:|.||:
  Fly   287 QQRPFACPLCPARFLRKSNHKQHLKVHER 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368	5/11 (45%)
		zf-H2C2_2	389..414	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..483	CDD:275368	0/20 (0%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368	4/19 (21%)
		C2H2 Zn finger	652..673	CDD:275368	6/20 (30%)
		C2H2 Zn finger	681..701	CDD:275368	9/21 (43%)
		zf-H2C2_2	694..718	CDD:290200	10/23 (43%)
		C2H2 Zn finger	709..729	CDD:275368	6/19 (32%)
		tolA_full	724..>814	CDD:274303	4/8 (50%)
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	9/19 (47%)
		zf-H2C2_2	113..138	CDD:290200	12/24 (50%)
		C2H2 Zn finger	129..149	CDD:275368	5/19 (26%)
		zf-H2C2_2	142..166	CDD:290200	11/52 (21%)
		COG5048	151..>264	CDD:227381	37/230 (16%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		C2H2 Zn finger	185..206	CDD:275368	3/21 (14%)
		C2H2 Zn finger	235..255	CDD:275368	6/20 (30%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930