DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and Plag1

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001008317.1	Gene:	Plag1 / 297804	RGDID:	1305286	Length:	499	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	111/443 - (25%)
Similarity:	164/443 - (37%)	Gaps:	88/443 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 SESDDSEDGTS----RGDKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQ 307
            ||..|::...|    ||:...||..|           |.:|.:.|....:.:.|...|....|::
  Rat    10 SEVRDTQKAPSGKRKRGESKPRKNFP-----------CQLCDKAFNSVEKLKVHSFSHTGERPYK 63

  Fly   308 CKVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPL 372
            |..:.|.|.|.:...|:.|:  |.....:.|.|  ..|.|.|.|...|..|: ..|...|
  Rat    64 CTHQDCTKAFVSKYKLQRHM--ATHSPEKTHKC--NYCEKMFHRKDHLKNHL-HTHDPNK----- 118

  Fly   373 RDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYC 437
            ..|.|.||...:......|:|:..|........|.:|.:.|.....|.:||..|||..:.
  Rat   119 ETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSG----- 178

  Fly   438 GVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFG-KS 501
            ||                ||||.:|..|:...:.::.:..|: |||..||||.||||.:.|| |.
  Rat   179 GV----------------KEKKHQCEHCERRFYTRKDVRRHM-VVHTGRKDFLCQYCAQRFGRKD 226

  Fly   502 HACKVHERSHTGEKCCECKICGKI----------FLCEKSLTKHLKTHEKRDLPPAEPLRQ---- 552
            |..:..::||..|..       |:          |.|..|:....:......||.:|.|.:
  Rat   227 HLTRHMKKSHNQELL-------KVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSELLSKPFTN 284

  Fly   553 --QLNI---PMPGQMSVPMPGQMPMQMQTDGLVPMDPNQM-PSEDMLKACGGGTA----AVPPKP 607
              |||:   |.....|.....||...:......|:|.:.: ||..:...|...:.    ::|.|.
  Rat   285 TLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKCPFSSTSYAISIPEKE 349

  Fly   608 KNSRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTK--KEGQHICPGCGRG 658
            :..:......:.:|.|.|    ||.|..|   |.:.:|  .|.|...|..|.|
  Rat   350 QPLKGEIESYLMELQGGA----PSSSQDS---QASSSKLGLEPQSGSPDDGAG 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	6/18 (33%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		zf-H2C2_2	389..414	CDD:290200	5/24 (21%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	2/19 (11%)
		C2H2 Zn finger	462..483	CDD:275368	4/20 (20%)
		C2H2 Zn finger	491..511	CDD:275368	8/20 (40%)
		C2H2 Zn finger	519..539	CDD:275368	4/29 (14%)
		C2H2 Zn finger	652..673	CDD:275368	3/7 (43%)
		C2H2 Zn finger	681..701	CDD:275368
		zf-H2C2_2	694..718	CDD:290200
		C2H2 Zn finger	709..729	CDD:275368
		tolA_full	724..>814	CDD:274303
Plag1	NP_001008317.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		7/22 (32%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		21/86 (24%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		0/2 (0%)
		C2H2 Zn finger	36..56	CDD:275368	4/19 (21%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		64/239 (27%)
		SFP1	<58..139	CDD:227516	23/90 (26%)
		C2H2 Zn finger	64..86	CDD:275368	7/23 (30%)
		zf-H2C2_2	79..103	CDD:404364	8/27 (30%)
		C2H2 Zn finger	94..114	CDD:275368	7/22 (32%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		C2H2 Zn finger	187..207	CDD:275368	4/20 (20%)
		C2H2 Zn finger	215..233	CDD:275368	8/17 (47%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		35/160 (22%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		30/146 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..400		13/39 (33%)
		Massively activates transcription. /evidence=ECO:0000250	384..499		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100