Protein Alignment D19A and ZNF281

DIOPT Version :10

• Sequence 1: NP_477304.1
• Gene: D19A / 38718
• FlyBaseID: FBgn0022935
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: NP_036614.1
• Gene: ZNF281 / 23528
• HGNCID: 13075
• Length: 895
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 72/310 - (23%)
• Similarity: 110/310 - (35%)
• Gaps: 72/310 - (23%)

  Fly   230 KKIKPPPPEEEELSDSSSESDDSEDGTSRGDKPKRKRIPIEERHLHRII-DCHICHQKFKKAIRY 293
            |:.||..|||::  ...........|...|.:.:...:...|...|.:| |..|.||..:
Human   128 KQEKPADPEEQQ--SHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQ----- 185

  Fly   294 EEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFH 358
            ::..::|.|:|              .::..|.. ||..||                        .
Human   186 QQPAQHHRDVL--------------LSSSSRTD-DHHGTE------------------------E 211

  Fly   359 MKKVHGITKAAAPLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHL 423
            .|:...:.||..|.   |.::.....|.|:|..|......||.            .|.|..:
Human   212 PKQDTNVKKAKRPK---PESQGIKAKRKPSASSKPSLVGDGEG------------AILSPSQ--- 258

  Fly   424 MRHAGIKNHVCPYCGVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKD 488
                  |.|:|.:|.....:......|:|.||.|:.|:|.||......|..|..|.| :|.:.|.
Human   259 ------KPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEK-IHSREKP 316

  Fly   489 FACQYCGKTFGKSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKT 538
            |.|..|...|.:.:..:.|:|:|:|||..:|..|.:.|.....|.||.:|
Human   317 FGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRT 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		SFP1	<291..363	CDD:227516	9/71 (13%)
		C2H2 Zn finger	343..362	CDD:275368	1/18 (6%)
		C2H2 Zn finger	377..397	CDD:275368	4/19 (21%)
		zf-H2C2_2	389..414	CDD:463886	4/24 (17%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	462..483	CDD:275368	7/20 (35%)
		C2H2 Zn finger	491..511	CDD:275368	5/19 (26%)
		C2H2 Zn finger	519..539	CDD:275368	7/20 (35%)
		C2H2 Zn finger	652..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		zf-C2H2	707..729	CDD:395048
		C2H2 Zn finger	709..729	CDD:275368
ZNF281	NP_036614.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..149		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..253		19/128 (15%)
		zf-C2H2_4	261..283	CDD:464025	5/21 (24%)
		C2H2 Zn finger	263..283	CDD:275368	4/19 (21%)
		zf-H2C2_2	275..300	CDD:463886	9/24 (38%)
		C2H2 Zn finger	291..311	CDD:275368	7/20 (35%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..356	CDD:463886	9/24 (38%)
		C2H2 Zn finger	347..366	CDD:275368	6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..427
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..817