DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19A and znf-782

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_500033.1	Gene:	znf-782 / 190310	WormBaseID:	WBGene00021931	Length:	662	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	144/697 - (20%)
Similarity:	227/697 - (32%)	Gaps:	258/697 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 EEEDHVNYDPLLNHKMELIENEEDVFKMLEHVDKEAEEVEKEAKVEEDDGGNVSVKMFDDDSSIE 175
            |||:...|:.      ||:|.||:       .|:|.||:|..                |..||:.
Worm    25 EEEEFEEYED------ELLEEEEE-------FDEELEELENS----------------DSASSLV 60

  Fly   176 SGNDNDHDLDFEPNSSDDDIPLAQRMRGPATGSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEE 240
            |.. :.|.......|.....||  :::.|:.|||....           |.|:|
Worm    61 SAG-SPHGSSSSNGSHGSSPPL--QVQSPSQGSGSSGS-----------PTGQP----------- 100

  Fly   241 ELSDSSSESDDSEDGTSRGDKPKRKRIPIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLP 305
                                         |:||:     |.:|.:.|......|.|.:.|....|
Worm   101 -----------------------------EKRHI-----CTVCGKGFSYFSILESHKRSHTGEKP 131

  Fly   306 FQCKVETCKKGFTTANGLRIHIDHAHTELSEVHACIAEGCGKTFPRVRLLTFHMKKVH-GITKAA 369
            :.|  ..|:|.|.....|::| :..||. ...:.|  ..|.|||.:....|.|.|..| ||
Worm   132 YNC--HFCQKTFAQKATLQVH-ERTHTG-ERPYKC--RYCEKTFAQYGTKTVHEKSAHLGI---- 186

  Fly   370 APLRDFPCTECDTVFRCPTALKKHMYKHTGEELPYPCNICGKRFVINSALRDHL--MRHAGIKNH 432
               |::.|.:||.:...|:||..|  |.|..:..:.|:.|.|.|.:.:.|:.|:  :.....:.|
Worm   187 ---RNYKCPKCDKLLSSPSALYTH--KKTHGDKTFRCDFCPKTFALKNYLKLHVKQVHEQNERKH 246

  Fly   433 VCPYCGVGKTTRQEWNAHILTHTKEKKFKCRQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKT 497
            ||.||..|.........|:.|||.|                             :.:.|::|.|.
Worm   247 VCVYCNKGFAYAGSLQVHVRTHTGE-----------------------------RPYVCKFCPKA 282

  Fly   498 FGKSHACKVHERSHTGEKCCECKICGKIFLCEKSLTKHLKTH--EKRDLPPAEPLRQQLNIPMPG 560
            |......:.|||:||||:...|:.|.:.|:.:..||.|..||  :|..:.|
Worm   283 FASQGNLQSHERTHTGERPYSCQFCQRTFIQKSQLTAHESTHLTQKHSVNP-------------- 333

  Fly   561 QMSVPMPGQMPMQMQTDGLVPMDPNQMPSEDMLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTA 625
                                                 ..|.|              ||..:||:
Worm   334 -------------------------------------DSTTA--------------DILPVAGS- 346

  Fly   626 VNPIPSVSVPSWSPQVNFTKKEGQHICPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFCPKRFSK 690
                           |...:..|.:.|..|.:.:....::.:|.: .|.:...::|..|.|.:|:
Worm   347 ---------------VTDHQMVGNYECTFCNKKYPYASSLYIHMR-KHTEKSAYSCDGCGKPYSQ 395

  Fly   691 AQILRHHE--------WIHTGEKPF--ECKICGKHFRQETALKKHI------------KTHEKPN 733
            ...|..|:        .:.|.:..|  .|..|||.|.|..||:.|:            |..::.|
Worm   396 KISLNIHQDQCEAFKNRLKTTDSQFSHNCDGCGKSFVQRIALQIHVDSCEPHKNLARLKLSQQQN 460

  Fly   734 RRHVPERSAPTQI--------------TFRKLEPDAEPRNFDQYQDP 766
            :....:..:.|::              |.:::.|   |.|....|.|
Worm   461 QNQNSDSESDTEMKICPLPNPPLTLAPTHQQIPP---PVNIYAQQPP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	7/18 (39%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..414	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	6/21 (29%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..483	CDD:275368	0/20 (0%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	519..539	CDD:275368	6/19 (32%)
		C2H2 Zn finger	652..673	CDD:275368	3/20 (15%)
		C2H2 Zn finger	681..701	CDD:275368	6/27 (22%)
		zf-H2C2_2	694..718	CDD:290200	9/33 (27%)
		C2H2 Zn finger	709..729	CDD:275368	10/31 (32%)
		tolA_full	724..>814	CDD:274303	10/69 (14%)
znf-782	NP_500033.1	C2H2 Zn finger	106..126	CDD:275368	5/19 (26%)
		zf-H2C2_2	119..143	CDD:290200	8/25 (32%)
		C2H2 Zn finger	134..154	CDD:275368	6/22 (27%)
		zf-H2C2_2	147..171	CDD:290200	9/27 (33%)
		C2H2 Zn finger	162..180	CDD:275368	7/19 (37%)
		COG5048	<187..404	CDD:227381	66/329 (20%)
		C2H2 Zn finger	191..211	CDD:275370	8/21 (38%)
		C2H2 Zn finger	218..239	CDD:275368	6/20 (30%)
		C2H2 Zn finger	248..268	CDD:275368	5/19 (26%)
		zf-H2C2_2	260..285	CDD:290200	9/53 (17%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	10/24 (42%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..403	CDD:275368	5/16 (31%)
		C2H2 Zn finger	424..441	CDD:275368	8/16 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000