DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19A and ZNF555

DIOPT Version :9

Sequence 1:	NP_477304.1	Gene:	D19A / 38718	FlyBaseID:	FBgn0022935	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_011526018.1	Gene:	ZNF555 / 148254	HGNCID:	28382	Length:	630	Species:	Homo sapiens

Alignment Length:	678	Identity:	175/678 - (25%)
Similarity:	274/678 - (40%)	Gaps:	119/678 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 VFDPNVAVQDYPAEE---EDHVNYDPLLNHKMELIEN-----EEDVFKMLEHVDKE---AEEVEK 151
            ||: :||| |:..||   .|....|...:..:|..:|     :|..||....|.::   .|::.|
Human     7 VFE-DVAV-DFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQFKASGSVSQQDIYGEKIPK 69

  Fly   152 EAKV----EEDDGGNVSVKMFD----DDSSIESGND--NDHDLDFEPNSSDDDIPLAQRMRGPAT 206
            |:|:    ......:|..|::|    :|.:...|.:  .:|.|:....|:|        ..|.|.
Human    70 ESKIATFTRNVSWASVLGKIWDSLSIEDQTTNQGRNLSRNHGLERLCESND--------QCGEAL 126

  Fly   207 GSGPQQDRFSNLDKPKPRPRGRPKKIKPPPPEEEELSDSSSESDDSEDGTSRGDKPKRKRI---- 267
            ...|..:.:              ||| ||..::.|.:             :.|.....:|.
Human   127 SQIPHLNLY--------------KKI-PPGVKQYEYN-------------TYGKVFMHRRTSLKS 163

  Fly   268 PIEERHLHRIIDCHICHQKFKKAIRYEEHMKYHNDLLPFQCKVETCKKGFTTANGLRIHIDHAHT 332
            ||.....|:...|..|.|.:........|::.||...|:.||:  |.|.|...:.|..|: ..||
Human   164 PITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGERPYVCKL--CGKTFPRTSSLNRHV-RIHT 225

  Fly   333 ELSEVHACIAEGCGKTFPRVRLLTFHMKKVHGITKAAAPLRDFPCTECDTVFRCPTALKKHMYKH 397
             ..:.:.|  :.|||.|.....||.|::...|       .:.:.|.||...|...:..::|...|
Human   226 -AEKTYEC--KQCGKAFIDFSSLTSHLRSHTG-------EKPYKCKECGKAFSYSSTFRRHTITH 280

  Fly   398 TGEELPYPCNICGKRFVINSALRDHLMRHAGIKNHVCPYCGVGKTTRQEWNAHILTHTKEKKFKC 462
            |||: ||.|..|.:.|..:|..|.|::.|.|.|.|.|..||...:....:..|::|||.||.::|
Human   281 TGEK-PYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYSSAFRRHMITHTGEKPYEC 344

  Fly   463 RQCDHASHNKQALSNHVKVVHEKRKDFACQYCGKTFGKSHACKVHERSHTGEKCCECKICGKIFL 527
            :||.......|:...|.: :|...|.:.|:.|||||....:.:.|||:|.|||..||..|||.|.
Human   345 KQCGKTFIYLQSFRRHER-IHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFS 408

  Fly   528 CEKSLTKHLKTHEKRDLPPAEPLRQQLNIPMPGQMSVPMPGQMPMQMQTDGL-VPMDPNQMPSED 591
            ...|...|::.|........:...:..|.|:          .:...|:|... .|.:..|.....
Human   409 HPSSFRGHMRVHTGEKPYECKQCGKTFNWPI----------SLRKHMRTHTREKPYECKQCGKAF 463

  Fly   592 MLKACGGGTAAVPPKPKNSRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGQHI----- 651
            .|.||......:.|:.|:..       .:|.|.|           :...::..|...:|.
Human   464 SLSACFREHVRMHPEDKSYE-------CKLCGKA-----------FYCHISLQKHMRRHTAEKLY 510

  Fly   652 -CPGCGRGFNNIGNMKLHYKIIHEKVKDFACRFCPKRFSKAQILRHHEWIHTGEKPFECKICGKH 715
             |..||:.|:....::.|.: .|...|.:.|:.|.|.|.....|..|..:||||||::||.|||.
Human   511 KCKQCGKAFSWPELLQQHVR-THTVEKPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKA 574

  Fly   716 FRQETALKKHIKTHE-----KPNRRHVP 738
            |...::|::|::.|.     |.|..|.|
Human   575 FNCSSSLRRHVRIHTTEKQYKCNVGHPP 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19A	NP_477304.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	343..362	CDD:275368	7/18 (39%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		zf-H2C2_2	389..414	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	462..483	CDD:275368	5/20 (25%)
		C2H2 Zn finger	491..511	CDD:275368	9/19 (47%)
		C2H2 Zn finger	519..539	CDD:275368	7/19 (37%)
		C2H2 Zn finger	652..673	CDD:275368	5/20 (25%)
		C2H2 Zn finger	681..701	CDD:275368	6/19 (32%)
		zf-H2C2_2	694..718	CDD:290200	14/23 (61%)
		C2H2 Zn finger	709..729	CDD:275368	8/19 (42%)
		tolA_full	724..>814	CDD:274303	6/20 (30%)
ZNF555	XP_011526018.1	KRAB	6..>50	CDD:214630	13/44 (30%)
		KRAB	6..45	CDD:279668	12/39 (31%)
		C2H2 Zn finger	151..168	CDD:275368	4/16 (25%)
		C2H2 Zn finger	176..196	CDD:275368	4/19 (21%)
		zf-H2C2_2	188..211	CDD:290200	8/24 (33%)
		COG5048	200..597	CDD:227381	123/440 (28%)
		C2H2 Zn finger	204..224	CDD:275368	7/22 (32%)
		zf-H2C2_2	216..239	CDD:290200	8/26 (31%)
		C2H2 Zn finger	232..252	CDD:275368	8/21 (38%)
		zf-H2C2_2	244..269	CDD:290200	8/31 (26%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..297	CDD:290200	10/24 (42%)
		C2H2 Zn finger	288..308	CDD:275368	6/19 (32%)
		zf-H2C2_2	301..325	CDD:290200	9/23 (39%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		zf-H2C2_2	328..353	CDD:290200	9/24 (38%)
		C2H2 Zn finger	344..364	CDD:275368	5/20 (25%)
		zf-H2C2_2	356..381	CDD:290200	9/25 (36%)
		C2H2 Zn finger	372..392	CDD:275368	9/19 (47%)
		zf-H2C2_2	384..409	CDD:290200	13/24 (54%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		zf-H2C2_2	412..436	CDD:290200	3/23 (13%)
		C2H2 Zn finger	428..448	CDD:275368	3/29 (10%)
		zf-H2C2_2	440..464	CDD:290200	4/23 (17%)
		C2H2 Zn finger	456..476	CDD:275368	4/19 (21%)
		C2H2 Zn finger	484..504	CDD:275368	4/30 (13%)
		zf-H2C2_2	496..520	CDD:290200	5/23 (22%)
		C2H2 Zn finger	512..532	CDD:275368	5/20 (25%)
		zf-H2C2_2	525..548	CDD:290200	6/23 (26%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		zf-H2C2_2	556..577	CDD:290200	13/20 (65%)
		C2H2 Zn finger	568..588	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12366
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860