DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and ZNF646

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_055514.3	Gene:	ZNF646 / 9726	HGNCID:	29004	Length:	1832	Species:	Homo sapiens

Alignment Length:	823	Identity:	166/823 - (20%)
Similarity:	264/823 - (32%)	Gaps:	276/823 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 GEEEDNVHFDPLLNSKIEIIENEEDVFKMLESVEKEVEEVEMEMEQPFGRV----SQDDSFESGN 170
            ||||......|..:..:::.|.|     :|..:::|||.::   ...:|.:    .|
Human   917 GEEEGVAEAAPARSPPLQLSEAE-----LLNQLQREVEALD---SAGYGHICGCCGQ-------- 965

  Fly   171 DNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPKS-----------------------AAKR 212
                       :.||:...:|..:..:.|:.|...|..                       :.:.
Human   966 -----------TYDDLGSLERHHQSQSSGTTADKAPSPLGVAGDAMEMVVDSVLEDIVNSVSGEG 1019

  Fly   213 QEEESEESEETSSSD-------DSDGNPKDKPKR-KRIPATERD-----RHRLID------CHIC 258
            .:.:|:|...|...|       :|....:.:|.| .:...|.|.     .||.|.      |.:|
Human  1020 GDAKSQEGAGTPLGDSLCIQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFLCPVC 1084

  Fly   259 HQKFKKAIRYEEHMKHH-------------------NDLL-------------------PFQCTV 285
            .:.:.....|..|:::|                   ::|.                   |.|..|
Human  1085 SRCYPNLAAYRNHLRNHPRCKGSEPQVGPIPEAAGSSELQVGPIPEGGSNKPQHMAEEGPGQAEV 1149

  Fly   286 ESCRKGF------------------TTANG------LRVHVEHAHTETSAMHPCTYEGCNKSFAR 326
            |..::..                  ||..|      |....:...||.|:..|.:.|.|.:|:..
Human  1150 EKLQEELKVEPLEEVARVKEEVWEETTVKGEEIEPRLETAEKGCQTEASSERPFSCEVCGRSYKH 1214

  Fly   327 PVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVL 391
            ...|..| ::.|:..    .|.|..|.|.|....:||.|...| .:...|.|..|||.|.:...|
Human  1215 AGSLINH-RQSHQTG----HFGCQACSKGFSNLMSLKNHRRIH-ADPRRFRCSECGKAFRLRKQL 1273

  Fly   392 ----RDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVK 452
                |.|:.|..|        .|..|.||:           ::.:.|.||.....:..:|.|| :
Human  1274 ASHQRVHMERRGG--------GGTRKATRE-----------DRPFRCGQCGRTYRHAGSLLNH-R 1318

  Fly   453 VVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEK----------CCECKICGKVFLFEKGLTKH 507
            ..||..: ::|..|.||:....|.|.|:|.|:..:          ...|.:||:.|.....|.:|
Human  1319 RSHETGQ-YSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERH 1382

  Fly   508 LKTHEKRDLPKTQGTNALMGDGAS-----GSSTI------AKPSPHLRGRVERVD---------- 551
            |:.||:.:.....|...|.|..||     ||..:      |:|.|||...|.|..
Human  1383 LREHEETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDGVPRPGERSQSPIRAA 1447

  Fly   552 -------------------------------IAQLAGTVANPIPSV------------------N 567
                                           :.|.......|..||                  :
Human  1448 SSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHAGDCQLNGPTLSH 1512

  Fly   568 LPSWSPQVNFTK-KEGQH-ICPDCGKGF-------NHVSN-MKLHYKVVHQKVKDFCCRFCPKRF 622
            :.||..:.|.:: :.|.| .|..|||.:       ||.:| ...||           |..|.|.|
Human  1513 MDSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHY-----------CLLCSKEF 1566

  Fly   623 AKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKVHDK-PPRPPGKPKEPAGPKA---ES 683
            ......:.|.:.|...:.:.|..|||.|...|.|.:|::.|.: ..:.|.:.:|...|||   |.
Human  1567 LNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHARGHSQVPAQMEEARDPKAGTGED 1631

  Fly   684 STAV----KRQQ-PKNFEQYQDPAAERAAATAELLAYQIEENE 721
            ...:    |.|: |....:....:.|||.....:.:...|:.|
Human  1632 QVVLPGQGKAQEAPSETPRGPGESVERARGGQAVTSMAAEDKE 1674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	15/75 (20%)
		C2H2 Zn finger	318..338	CDD:275368	5/19 (26%)
		COG5048	<347..512	CDD:227381	48/178 (27%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	8/23 (35%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..455	CDD:275368	6/20 (30%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..607	CDD:275368	9/28 (32%)
		C2H2 Zn finger	615..635	CDD:275368	5/19 (26%)
		zf-H2C2_2	627..652	CDD:290200	7/24 (29%)
		C2H2 Zn finger	643..663	CDD:275368	8/19 (42%)
ZNF646	NP_055514.3	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..47
		C2H2 Zn finger	50..70	CDD:275368
		zf-C2H2	75..97	CDD:333835
		C2H2 Zn finger	77..97	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..200
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..346
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	577..597	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	646..663	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..810
		C2H2 Zn finger	823..843	CDD:275368
		C2H2 Zn finger	850..870	CDD:275368
		C2H2 Zn finger	883..901	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..931		5/13 (38%)
		C2H2 Zn finger	1054..1074	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1081..1101	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1148		3/44 (7%)
		C2H2 Zn finger	1205..1225	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1232..1252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1260..1280	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1294		6/27 (22%)
		C2H2 Zn finger	1301..1321	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1328..1348	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1366..1386	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1377..1481		19/103 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1529		3/19 (16%)
		C2H2 Zn finger	1533..1552	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1559..1579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1587..1611	CDD:275368	9/23 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1606..1672		13/65 (20%)
		C2H2 Zn finger	1679..1699	CDD:275368
		C2H2 Zn finger	1706..1726	CDD:275368
		zf-H2C2_2	1718..1743	CDD:372612
		C2H2 Zn finger	1734..1754	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910