DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19B and znf1004

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001107936.1	Gene:	znf1004 / 799653	ZFINID:	ZDB-GENE-080219-20	Length:	934	Species:	Danio rerio

Alignment Length:	462	Identity:	139/462 - (30%)
Similarity:	199/462 - (43%)	Gaps:	97/462 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 DKPKR-----KRIPATERDR-HRLI-------DCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVE 286
            :||.:     ||....|..: |.:|       .|..|.::|.:....:.|.:.|....|::|.
Zfish   507 EKPYKCSHCDKRFNRLESQKSHEMIHTGEKSYKCSHCDKRFSQLQNQKIHERIHTGEKPYKCL-- 569

  Fly   287 SCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHM-----KRVHKVDTPQRD 346
            .|.|.|:....:::| |..||   ...|.|...|.||:.|...|:.||     |:.||
Zfish   570 HCGKRFSQLGNMKLH-ERIHT---GEKPYTCTQCGKSYGRSASLNNHMLIHTGKKTHK------- 623

  Fly   347 FPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGV 411
              |.:|.|.|...|.||.|:..||.|: |:.|.:|||||...:.|.:|...|.|:|.::|..|
Zfish   624 --CDQCGKSFLAATRLKTHLRFHTNEK-PYLCPVCGKRFAQKAYLSEHQKTHTGVKEYMCFEC-- 683

  Fly   412 GKT----TRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGK 472
            .||    .:.:|::.|  ||.||.|:|..||...:..:....|.: :|...|.:.|.:|||.|..
Zfish   684 DKTFLRAHQLKWHQTI--HTGEKPYKCSHCDKRFNRLERQTTHER-IHTGEKPYKCSHCGKRFSM 745

  Fly   473 SHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHL------KTHEKRDLPKTQGTNALMGDGAS 531
            ....|.||..|||||...|..|||.|.....|.:|:      |||:.....||..|.:.:
Zfish   746 LAHLKTHETIHTGEKPYTCTRCGKSFAQSSNLYRHMRIHTGVKTHKCDQCGKTFSTASCL----- 805

  Fly   532 GSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHV 596
                    ..|||...                                ||..:.|..|||.|:..
Zfish   806 --------KIHLRSHT--------------------------------KEKPYSCTVCGKSFSTQ 830

  Fly   597 SNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMK 661
            |:::||.| :|..:|::.|..|.|.|.....|:.|:.||||||||:|..|.|.|.:...|.||.:
Zfish   831 SSLRLHQK-IHTGLKEYMCFECEKTFISAAKLKRHQMIHTGEKPYKCSHCNKRFSELGNLTTHER 894

  Fly   662 VH--DKP 666
            :|  :||
Zfish   895 IHTGEKP 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	17/56 (30%)
		C2H2 Zn finger	318..338	CDD:275368	8/24 (33%)
		COG5048	<347..512	CDD:227381	62/174 (36%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..426	CDD:275368	6/23 (26%)
		C2H2 Zn finger	434..455	CDD:275368	4/20 (20%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	491..511	CDD:275368	8/25 (32%)
		C2H2 Zn finger	586..607	CDD:275368	9/20 (45%)
		C2H2 Zn finger	615..635	CDD:275368	6/19 (32%)
		zf-H2C2_2	627..652	CDD:290200	14/24 (58%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
znf1004	NP_001107936.1	C2H2 Zn finger	64..84	CDD:275368
		zf-H2C2_2	76..101	CDD:290200
		COG5048	88..502	CDD:227381
		C2H2 Zn finger	92..112	CDD:275368
		C2H2 Zn finger	120..140	CDD:275368
		C2H2 Zn finger	148..168	CDD:275368
		C2H2 Zn finger	176..196	CDD:275368
		C2H2 Zn finger	204..224	CDD:275368
		zf-H2C2_2	216..241	CDD:290200
		C2H2 Zn finger	232..252	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		C2H2 Zn finger	316..336	CDD:275368
		C2H2 Zn finger	344..364	CDD:275368
		C2H2 Zn finger	372..392	CDD:275368
		zf-H2C2_2	384..409	CDD:290200
		C2H2 Zn finger	400..420	CDD:275368
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368
		COG5048	480..864	CDD:227381	120/423 (28%)
		C2H2 Zn finger	484..504	CDD:275368
		zf-H2C2_2	497..521	CDD:290200	4/13 (31%)
		C2H2 Zn finger	512..532	CDD:275368	4/19 (21%)
		C2H2 Zn finger	540..560	CDD:275368	4/19 (21%)
		C2H2 Zn finger	568..588	CDD:275368	6/22 (27%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368	8/19 (42%)
		C2H2 Zn finger	652..672	CDD:275368	8/19 (42%)
		C2H2 Zn finger	680..700	CDD:275368	6/23 (26%)
		C2H2 Zn finger	708..728	CDD:275368	4/20 (20%)
		C2H2 Zn finger	736..756	CDD:275368	8/19 (42%)
		C2H2 Zn finger	764..784	CDD:275368	7/19 (37%)
		zf-H2C2_2	776..801	CDD:290200	7/24 (29%)
		C2H2 Zn finger	792..812	CDD:275368	6/32 (19%)
		C2H2 Zn finger	820..840	CDD:275368	9/20 (45%)
		C2H2 Zn finger	848..868	CDD:275368	6/19 (32%)
		C2H2 Zn finger	876..896	CDD:275368	7/19 (37%)
		zf-H2C2_2	888..913	CDD:290200	6/14 (43%)
		C2H2 Zn finger	904..924	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000