DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment D19B and ZNF225

DIOPT Version :10

Sequence 1:NP_477297.1 Gene:D19B / 38717 FlyBaseID:FBgn0022699 Length:774 Species:Drosophila melanogaster
Sequence 2:NP_037494.2 Gene:ZNF225 / 7768 HGNCID:13018 Length:706 Species:Homo sapiens


Alignment Length:686 Identity:184/686 - (26%)
Similarity:268/686 - (39%) Gaps:152/686 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 DNVHFDPLLNSKIEIIENEEDVFKMLE-SVEKEVE---EVEMEME--------------QPFGRV 160
            |..||            .:|:.|.|:| :.::|..   :::||||              |.:.::
Human    55 DTFHF------------LKEEKFWMMETATQREGNLGGKIQMEMETVSESGTHEGLFSHQTWEQI 107

  Fly   161 SQD-DSFESGNDNDLDADFQISSDDDIPLAQRS-------RRGATRGSKAKGKPKSAAKRQEEES 217
            |.| ..|:....|    .||.|..||:|....:       |:..:.|...|......:.....:.
Human   108 SSDLTRFQDSMVN----SFQFSKQDDMPCQVDAGLSIIHVRQKPSEGRTCKKSFSDVSVLDLHQQ 168

  Fly   218 EESEETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQ 282
            .:|.|.|.:.|..|.........||........:|.:|.:|.::|.::...:.|.:.|....||:
Human   169 LQSREKSHTCDECGKSFCYSSALRIHQRVHMGEKLYNCDVCGKEFNQSSHLQIHQRIHTGEKPFK 233

  Fly   283 CTVESCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDF 347
            |  |.|.|||:..:||.|| ...||.... |.|  |.|.|:|.....|..| :|:|   |.::.|
Human   234 C--EQCGKGFSRRSGLYVH-RKLHTGVKP-HIC--EKCGKAFIHDSQLQEH-QRIH---TGEKPF 288

  Fly   348 PCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVG 412
            .|..|.|.||....|.:|...|..|: ||.|:.|||.|.:.|.|..|.:.|.|.|.:.|..||..
Human   289 KCDICCKSFRSRANLNRHSMVHMREK-PFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECGKR 352

  Fly   413 KTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTF------- 470
            ...||:..||.:.||.||.|.|::|..:......|:.||: ||.....|.|:.|||.|       
Human   353 FIYRQDLYKHQIDHTGEKPYNCKECGKSFRWASGLSRHVR-VHSGETTFKCEECGKGFYTNSQRY 416

  Fly   471 --------GKSHACK-------------IHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHE-- 512
                    .|.:.|:             .|:|.|.|||...||.|||.|.:...|..|.:.|.  
Human   417 SHQRAHSGEKPYRCEECGKGYKRRLDLDFHQRVHRGEKPYNCKECGKSFGWASCLLNHQRIHSGE 481

  Fly   513 ---------KRDLPKTQ-GTNALMGDGAS-------GSSTIAKPSPHLRGRVE------------ 548
                     ||....:| .|:..:..|..       |.........:...||.            
Human   482 KPFKCEECGKRFTQNSQLYTHRRVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECG 546

  Fly   549 -------RVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVV 606
                   .:|:.|...|...|                     :.|.:|||.|:..|:: |::|.:
Human   547 KGFNSKFNLDMHQRVHTGERP---------------------YNCKECGKSFSRASSI-LNHKRL 589

  Fly   607 HQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKVHDKPPRPPG 671
            |...|.|.|..|.|||.:...|..|:.:|||||||:|:.|||.||......||.::|.   |...
Human   590 HGDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYKCEKCGKSFRWASTHLTHQRLHS---REKL 651

  Fly   672 KPKEPAGPKAESSTAVKRQQPKNFEQYQDPAAERAA 707
            ...|..|.....|:.:|.||       :|.:.|:.:
Human   652 LQCEDCGKSIVHSSCLKDQQ-------RDQSGEKTS 680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
D19BNP_477297.1 zf-AD 12..83 CDD:214871
C2H2 Zn finger 255..275 CDD:275368 4/19 (21%)
SFP1 <266..365 CDD:227516 34/98 (35%)
C2H2 Zn finger 283..335 CDD:275368 20/51 (39%)
C2H2 Zn finger 318..338 CDD:275368 7/19 (37%)
COG5048 <347..512 CDD:227381 64/192 (33%)
C2H2 Zn finger 349..369 CDD:275368 7/19 (37%)
C2H2 Zn finger 378..398 CDD:275368 8/19 (42%)
C2H2 Zn finger 406..426 CDD:275368 7/19 (37%)
C2H2 Zn finger 434..455 CDD:275368 5/20 (25%)
C2H2 Zn finger 463..483 CDD:275368 9/47 (19%)
C2H2 Zn finger 491..511 CDD:275368 8/19 (42%)
C2H2 Zn finger 586..607 CDD:275368 8/20 (40%)
C2H2 Zn finger 615..635 CDD:275368 7/19 (37%)
zf-H2C2_2 627..652 CDD:463886 14/24 (58%)
C2H2 Zn finger 643..663 CDD:275368 8/19 (42%)
ZNF225NP_037494.2 KRAB 8..67 CDD:214630 5/23 (22%)
C2H2 Zn finger 153..170 CDD:275368 1/16 (6%)
C2H2 Zn finger 178..198 CDD:275368 4/19 (21%)
COG5048 202..634 CDD:227381 137/465 (29%)
C2H2 Zn finger 206..226 CDD:275368 4/19 (21%)
C2H2 Zn finger 234..254 CDD:275368 10/22 (45%)
C2H2 Zn finger 262..282 CDD:275368 8/22 (36%)
C2H2 Zn finger 290..310 CDD:275368 7/19 (37%)
C2H2 Zn finger 318..338 CDD:275368 8/19 (42%)
C2H2 Zn finger 346..366 CDD:275368 7/19 (37%)
C2H2 Zn finger 374..394 CDD:275368 5/20 (25%)
C2H2 Zn finger 402..422 CDD:275368 5/19 (26%)
C2H2 Zn finger 430..450 CDD:275368 3/19 (16%)
C2H2 Zn finger 458..478 CDD:275368 8/19 (42%)
C2H2 Zn finger 486..506 CDD:275368 4/19 (21%)
C2H2 Zn finger 514..534 CDD:275368 2/19 (11%)
C2H2 Zn finger 542..562 CDD:275368 2/19 (11%)
C2H2 Zn finger 570..590 CDD:275368 8/20 (40%)
C2H2 Zn finger 598..618 CDD:275368 7/19 (37%)
C2H2 Zn finger 626..646 CDD:275368 8/19 (42%)
C2H2 Zn finger 654..672 CDD:275368 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

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