DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D19B and ZNF221

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001284517.1	Gene:	ZNF221 / 7638	HGNCID:	13014	Length:	617	Species:	Homo sapiens

Alignment Length:	587	Identity:	151/587 - (25%)
Similarity:	233/587 - (39%)	Gaps:	134/587 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EDNVHFDPLLNSKIEIIENEEDVFKMLESVEKEVE---EVEMEME--------------QPFGRV 160
            :|..||           ..:|..:||..:.::|..   ::::|||              |.:.::
Human    76 QDTFHF-----------LGKEKFWKMKTTSQREGNSGGKIQIEMETVPEAGPHEEWSCQQIWEQI 129

  Fly   161 SQDDSFESGNDNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPKSAAKRQEEESEES----E 221
            :.|   .:.:.|.:....|...:.|:|....:|...   |..:.||....:.::..|:.|    .
Human   130 ASD---LTRSQNSIRNSSQFFKEGDVPCQIEARLSI---SHVQQKPYRCNECKQSFSDVSVFDLH 188

  Fly   222 ETSSSDDSDGNPKDKPK----------RKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHN 276
            :.|.|.:......:..|          .:|:...|    :...|.:|.::|.::...:.|.:.|.
Human   189 QQSHSGEKSHTCGECGKSFCYSPALHIHQRVHMGE----KCYKCDVCGKEFNQSSHLQTHQRVHT 249

  Fly   277 DLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVD 341
            ...||:|  ..|.|||.:.:.|.||.: .||   ...|...|.|.|:|.....|..| :|:|
Human   250 GEKPFKC--GQCGKGFHSRSALNVHCK-LHT---GEKPYNCEECGKAFIHDSQLQEH-QRIH--- 304

  Fly   342 TPQRDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVC 406
            |.::.|.|..|.|.||..:.|.:|...||||: ||.|:.|||.|...|.|..|.:.|...|.:.|
Human   305 TGEKPFKCDICGKSFRVRSRLNRHSMVHTGEK-PFRCDTCGKNFRQRSALNSHSMVHIEEKPYKC 368

  Fly   407 PYCGVGKTTRQEWNKHILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFG 471
            ..||.|...|:::.||.:.||.||.|.|::|.........|.|| :.||..:|.|.|:.|||.|.
Human   369 EQCGKGFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNH-QQVHSGQKSFKCEECGKGFY 432

  Fly   472 KSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTI 536
            .:.....|:|||.|||...|:.|||.:.....|..|.:.|                   :|
Human   433 TNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEFHQRVH-------------------TG---- 474

  Fly   537 AKPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHVSNMKL 601
                                                        |..:.|.:|||.|...|.:..
Human   475 --------------------------------------------ERPYNCKECGKSFGWASCLLK 495

  Fly   602 HYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKVH--D 664
            |.: :|...|.|.|..|.|||.:...|..|:..|||||.|:|:.|.|.:..:..|..|.:||  :
Human   496 HQR-LHSGEKPFKCEECGKRFTQSSQLHSHQTCHTGEKLYKCEQCEKGYNSKFNLDMHQRVHGGE 559

  Fly   665 KP 666
            :|
Human   560 RP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..335	CDD:275368	17/51 (33%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		COG5048	<347..512	CDD:227381	63/164 (38%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..455	CDD:275368	5/20 (25%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	586..607	CDD:275368	7/20 (35%)
		C2H2 Zn finger	615..635	CDD:275368	7/19 (37%)
		zf-H2C2_2	627..652	CDD:290200	11/24 (46%)
		C2H2 Zn finger	643..663	CDD:275368	5/19 (26%)
ZNF221	NP_001284517.1	KRAB	30..70	CDD:307490
		COG5048	166..576	CDD:227381	133/480 (28%)
		C2H2 Zn finger	172..192	CDD:275368	2/19 (11%)
		C2H2 Zn finger	200..220	CDD:275368	2/19 (11%)
		C2H2 Zn finger	228..248	CDD:275368	4/19 (21%)
		C2H2 Zn finger	256..276	CDD:275368	8/22 (36%)
		C2H2 Zn finger	284..304	CDD:275368	7/20 (35%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		C2H2 Zn finger	396..416	CDD:275368	5/20 (25%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/20 (35%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	536..556	CDD:275368	5/19 (26%)
		C2H2 Zn finger	564..584	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910