Protein Alignment D19B and ZBTB4

DIOPT Version :10

• Sequence 1: NP_477297.1
• Gene: D19B / 38717
• FlyBaseID: FBgn0022699
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_065950.2
• Gene: ZBTB4 / 57659
• HGNCID: 23847
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 67/234 - (28%)
• Similarity: 93/234 - (39%)
• Gaps: 53/234 - (22%)

  Fly   491 CKICGKVFLFEKGLTKHLKTHEK--RDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIA 553
            |..|||.|:.    .|.|:|||.  |....|:|:..| |.|.:|..     .|
Human   236 CPQCGKSFIH----PKRLQTHEAQCRRGASTRGSTGL-GAGGAGPG-----GP------------ 278

  Fly   554 QLAGTVANPIPSVNLPSWSPQVNF-------TKKEGQH---ICPDCGKGFNHVSNMKLHYKVVHQ 608
              ||..|:.:|        |.|.|       .|..|.|   :|..|.:.:..:|::|.|.. ||.
Human   279 --AGVDASALP--------PPVGFRGGPEHVVKVVGGHVLYVCAACERSYVTLSSLKRHSN-VHS 332

  Fly   609 KVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKV-HDKPPRPPGK 672
            ..:.:.||:|.|.||..:|...||..||||:.|:|..|.:.|.....||||.:. |...|.....
Human   333 WRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLAS 397

  Fly   673 PKEPAG---PKAESSTAVK----RQQPKNFEQYQDPAAE 704
            .|.|.|   ||..:....:    |...:.::.|...|.|
Human   398 EKTPNGGYKPKLNTLKLYRLLPMRAAKRPYKTYSQGAPE 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368
		SFP1	<266..365	CDD:227516
		C2H2 Zn finger	283..335	CDD:275368
		C2H2 Zn finger	318..338	CDD:275368
		COG5048	<347..512	CDD:227381	8/20 (40%)
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..455	CDD:275368
		C2H2 Zn finger	463..483	CDD:275368
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..607	CDD:275368	5/20 (25%)
		C2H2 Zn finger	615..635	CDD:275368	9/19 (47%)
		zf-H2C2_2	627..652	CDD:463886	11/24 (46%)
		C2H2 Zn finger	643..663	CDD:275368	7/20 (35%)
ZBTB4	NP_065950.2	BTB_POZ	12..181	CDD:453885
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..124
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..221
		Interaction with CBFA2T3. /evidence=ECO:0000269|PubMed:23251453	186..348		40/144 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..281		9/43 (21%)
		C2H2 Zn finger	311..331	CDD:275368	5/20 (25%)
		C2H2 Zn finger	339..359	CDD:275368	9/19 (47%)
		C2H2 Zn finger	367..385	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..765		3/9 (33%)
		C2H2 Zn finger	728..748	CDD:275368
		zf-C2H2	765..787	CDD:395048
		C2H2 Zn finger	767..787	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..852
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1013