DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D19B and CG8301

DIOPT Version :9

Sequence 1:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	145/691 - (20%)
Similarity:	240/691 - (34%)	Gaps:	209/691 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SLSVEQADGFPKNLCNVCFSKLNDLHDFQKQCVDSVQKFQDLVASNAFACQTNFDVLDTSAAVAD 107
            :|.:...||.|:.:|:.||:|...::.|:..|.::..|...:           :|.:|.|:...|
  Fly    49 NLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHI-----------YDKIDASSLEDD 102

  Fly   108 LPGEEE-------------------------DNVHFDP--LLNSKIEIIENEEDVFKMLESVEKE 145
            ..|:|:                         :|...||  :....::|.|.||:     |..|::
  Fly   103 EIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEE-----EEEEEQ 162

  Fly   146 VEEVEMEMEQPFGRVSQDDSFESGNDNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPKSAA 210
            .::.:.|:|:|.    .|:|............|.:...::..|.|.    ......|...|:...
  Fly   163 QQQYDEEVEEPI----TDESAPPQLTISYACKFCLRPQENYQLQQL----LLEHINASHDPEQPY 219

  Fly   211 KRQEEESEESEETSSSDDSDGNPKDKPKRKRIPATE-RDRHRL------------IDCHICHQKF 262
            ...|.|:...:..|.:.....:..:|.....:...: .|||.|            .:|.:|.::|
  Fly   220 NCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRF 284

  Fly   263 --KKAIRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVH-VEHAHTETSAMHPCTYEGCNKSF 324
              :|::.|  |||.||....|:|....|.:.|.:...|..| ..|:.|.:.....|.:  |.|:|
  Fly   285 YTRKSLNY--HMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF--CGKTF 345

  Fly   325 ARPVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKHMYKHTGEELP----FACEICGKRF 385
            .....|.:|:.|.|..:.|   :.|..|.:||......:.||.:...|.|.    ..|.:|.:.|
  Fly   346 IHLKTLRWHIYRQHGGEKP---YKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPF 407

  Fly   386 P-----INSVLRDHLLRHAG--IKNHVCPYCGVGKTTRQEWNKHILTHTKEKKY----ECRQCDH 439
            .     |:.:..:||.|...  |.|                ||.:|...:|::|    :|..|..
  Fly   408 SSEPDLIHHMSAEHLQRPGAPIIAN----------------NKRVLQQKRERQYSGLFQCGSCSQ 456

  Fly   440 ASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGL 504
            ..:.|.||..|..|..||.:..||.:|.|.|.::...|.|.::|..||...|.:|||.|..:..|
  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521

  Fly   505 TKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVNLP 569
            |:|..:||..:
  Fly   522 TQHRLSHEVLE------------------------------------------------------ 532

  Fly   570 SWSPQVNFTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYI 634
                                                     |:|.|..|.:.:..::.||.|:..
  Fly   533 -----------------------------------------KNFKCNVCGRAYLFEKSLRLHQRT 556

  Fly   635 HTGEKPYECKVCGKHFRQEQVLKTHM-KVH--------DKP 666
            |||:..|:|.:|.:.|.....||||| |.|        |:|
  Fly   557 HTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D19B	NP_477297.1	zf-AD	12..83	CDD:214871	11/39 (28%)
		C2H2 Zn finger	255..275	CDD:275368	8/21 (38%)
		C2H2 Zn finger	283..335	CDD:275368	13/52 (25%)
		C2H2 Zn finger	318..338	CDD:275368	6/19 (32%)
		COG5048	<347..512	CDD:227381	49/179 (27%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	6/24 (25%)
		C2H2 Zn finger	406..426	CDD:275368	3/19 (16%)
		C2H2 Zn finger	434..455	CDD:275368	7/20 (35%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	586..607	CDD:275368	0/20 (0%)
		C2H2 Zn finger	615..635	CDD:275368	5/19 (26%)
		zf-H2C2_2	627..652	CDD:290200	10/24 (42%)
		C2H2 Zn finger	643..663	CDD:275368	9/20 (45%)
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	10/37 (27%)
		COG5048	198..>508	CDD:227381	80/336 (24%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	8/21 (38%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	7/22 (32%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930